Listeria monocytogenes Infection Alters the Content and Function of Extracellular Vesicles Produced by Trophoblast Stem Cells

Kaletka, Jonathan; Lee, Kun Ho; Altman, Josephine; Kanada, Masamitsu; Hardy, Jonathan

doi:10.1128/iai.00347-22

Cited by 3 publications

(1 citation statement)

References 77 publications

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“…In vitro evidence indicates that infection with L. monocytogenes causes trophoblasts to produce proinflammatory cytokines such as TNF-α and IL-6 in addition to chemokines CXCL8, CCL3, and CCL4 [ 85 ]. Extracellular vesicles from infected trophoblasts also communicate the presence of bacteria and can induce TNF-α production in naïve cells [ 86 ]. Interestingly, trophoblasts continue to produce IL-27, IL-10, and IL-1RA, immunosuppressive cytokines important for fetal tolerance, even after L. monocytogenes infection [ 85 ].…”

Section: Listeria Monocytogenesmentioning

confidence: 99%

Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion

Eallonardo,

Freitag

2023

Cells

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Vertically transmitted infections are a significant cause of fetal morbidity and mortality during pregnancy and pose substantial risks to fetal development. These infections are primarily transmitted to the fetus through two routes: (1) direct invasion and crossing the placenta which separates maternal and fetal circulation, or (2) ascending the maternal genitourinary tact and entering the uterus. Only two bacterial species are commonly found to cross the placenta and infect the fetus: Listeria monocytogenes and Treponema pallidum subsp. pallidum. L. monocytogenes is a Gram-positive, foodborne pathogen found in soil that acutely infects a wide variety of mammalian species. T. pallidum is a sexually transmitted spirochete that causes a chronic infection exclusively in humans. We briefly review the pathogenesis of these two very distinct bacteria that have managed to overcome the placental barrier and the role placental immunity plays in resisting infection. Both organisms share characteristics which contribute to their transplacental transmission. These include the ability to disseminate broadly within the host, evade immune phagocytosis, and the need for a strong T cell response for their elimination.

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Section: Listeria Monocytogenesmentioning

confidence: 99%

Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion

Eallonardo,

Freitag

2023

Cells

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Engineering of Trophoblast Extracellular Vesicle-Delivering Hydrogels for Localized Tolerance Induction in Cell Transplantation

Hiremath,

Weaver

2023

Cel. Mol. Bioeng.

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Placental extracellular vesicles in maternal-fetal communication during pregnancy

Martin

Bergamelli

Malnou

et al. 2022

Biochemical Society Transactions

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For several years, a growing number of studies have highlighted the pivotal role of placental extracellular vesicles (EVs) throughout pregnancy. These membrane nanovesicles, heterogeneous in nature, composition and origin, are secreted by several trophoblastic cell types and are found in both the maternal and fetal compartments. They can be uptaken by recipient cells and drive a wide variety of physiological and pathological processes. In this review, we provide an overview of the different described roles of placental EVs in various aspects of normal pregnancy, from placenta establishment to maternal immune tolerance towards the fetus and protection against viral infections. In the second part, we present selected examples of pathological pregnancies in which placental EVs are involved, such as gestational diabetes mellitus, pre-eclampsia, and congenital infections. Since the abundance and/or composition of placental EVs is deregulated in maternal serum during pathological pregnancies, this makes them interesting candidates as non-invasive biomarkers for gestational diseases and opens a wide field of translational perspectives.

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Listeria monocytogenes Infection Alters the Content and Function of Extracellular Vesicles Produced by Trophoblast Stem Cells

Cited by 3 publications

References 77 publications

Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion

Crossing the Barrier: A Comparative Study of Listeria monocytogenes and Treponema pallidum in Placental Invasion

Engineering of Trophoblast Extracellular Vesicle-Delivering Hydrogels for Localized Tolerance Induction in Cell Transplantation

Placental extracellular vesicles in maternal-fetal communication during pregnancy

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