Listeria monocytogenes as a cause of fetal loss

Lawler, Frank C.; Wood, Walter S.; King, Sylvia; Metzger, William I.

doi:10.1016/0002-9378(64)90061-4

Cited by 23 publications

(2 citation statements)

References 24 publications

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“…Of 34 women with a history of recurrent abortions and 87 controls, positive cultures were found in 73.5% and 0% respectively [119]. Other studies [4,84,92,93] failed to confirm these findings; therefore, routine genital tract culture and treatment are not recommended [138]. Nonetheless, although rare and because of the potentially serious consequences, it is important that practicing obstetricians are familiar with the diagnosis, treatment, and prevention of Listeria infection [124].…”

Section: Listeriosis In Pregnancymentioning

confidence: 99%

Listeriosis in human pregnancy: a systematic review

Lamont

Sobel²,

Mazaki‐Tovi

et al. 2011

Journal of Perinatal Medicine

282

243

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Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregnant women are at high risk for listeriosis, but symptoms are non-specific and diagnosis is difficult. The intracellular life-cycle of Listeria protects the bacterium from host innate and adaptive immune responses. Antibiotic treatment requires agents able to penetrate, distribute, and remain stable within host cells. Prolonged use of high-dose ampicillin can significantly improve neonatal outcome.

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Section: Listeriosis In Pregnancymentioning

confidence: 99%

Listeriosis in human pregnancy: a systematic review

Lamont

Sobel²,

Mazaki‐Tovi

et al. 2011

Journal of Perinatal Medicine

282

243

View full text Add to dashboard Cite

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“…The amniotic fluid is meconium stained in 75% of cases of maternal infection, particularly at early gestation, probably due to the ingestion of infected fluid, which causes fetal enteritis [31,44]. In a case series of women with positive cervical cultures for L. monocitogenes, these patients seemed to have a higher risk of recurrent abortion [45], although other studies failed to confirm these findings [18,[46][47][48]. Discordant infection can occur in twin pregnancy [49,50]: the infected twin is commonly in the presenting position and this can be related to the ascending route of infection from the vagina [51].…”

Section: Pregnancy Complicationsmentioning

confidence: 99%

Listeria Infection in Pregnancy: A Review of Literature

Luca¹,

Donati²,

D’Oria³

et al. 2015

TOIDJ

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Listeria monocytogenes, a Gram-positive bacterium, is responsible for human listeriosis. Infection with Listeria has been associated with the consumption of contaminated and/or inadequately cooked food, particularly dairy products, leafy vegetables, fish, and meat. The main clinical manifestations include diarrhea, nausea and vomiting, which are usually followed by fever and flu-like symptoms.Listeriosis affects pregnant women in about one in seven (14%) cases. They are approximately 10 times more likely to catch the disease than the general population. Although Listeria infection during pregnancy is usually uncomplicated for the mother, fetal and neonatal infection can be severe and fatal. Animal studies have shown a dose-response relationship between L. monocytogenes bacterial load and adverse pregnancy outcome, mainly pregnancy loss. Fetal and neonatal infection occurs through the transplacental passage of the bacterium or through exposure in the perinatal period. In pregnant women Listeria infection was associated with fetal loss, preterm birth, neonatal infection or neonatal death. Blood culture is the principal diagnostic tool and the antibiotic of choice for the treatment of listeriosis is penicillin, with high doses injected intravenously for at least 14 days. In case of suspected or confirmed maternal listeriosis, a program of fetal surveillance should be implemented. Common fetal ultrasound findings in listeria infection include non-immune hydrops, intracranial calcifications, and intrauterine fetal demise. Strategies for the prevention of listeriosis, including avoiding unpasteurized dairy products, uncooked food and leftover food, have significantly decreased the number of cases of infection. Prevention in pregnant women can be achieved by sticking to prophylactic measures and strict diet recommendations.

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