Listeria ivanovii infection

Lessing, M.P.A.; Curtis, Gordon D W; Bowler, I.C.J.W.

doi:10.1016/s0163-4453(94)90914-8

Cited by 44 publications

(39 citation statements)

References 5 publications

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“…L. monocytogenes causes serious infections in newborns, pregnant women, immunocompromised individuals (9,11,24), and animals (25). L. ivanovii is pathogenic to ruminants (25) but rarely causes human disease (6,23).…”

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confidence: 99%

Differences in Gamma Interferon Production Induced by Listeriolysin O and Ivanolysin O Result in Different Levels of Protective Immunity in Mice Infected with Listeria monocytogenes and Listeria ivanovii

et al. 2003

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Two pathogenic species in the genus Listeria, Listeria monocytogenes and Listeria ivanovii, are characterized by the production of hemolysins belonging to cholesterol-dependent cytolysins, listeriolysin O (LLO) and ivanolysin O (ILO), respectively. LLO, produced by L. monocytogenes, is able to induce gamma interferon (IFN-␥) production and contributes to the generation of Th1-dependent protective immunity. On the other hand, nothing is known about the role of ILO, produced by L. ivanovii, in this regard. In this study, we immunized mice with 0.1 50% lethal dose (LD 50 ) of L. monocytogenes and L. ivanovii. Protective immunity against a challenge with 10 LD 50 was generated in mice infected with L. monocytogenes, whereas L. ivanovii infection did not induce protection. After immunization, the level of IFN-␥ in serum samples was increased in mice given L. monocytogenes but not in those given L. ivanovii. To determine the IFN-␥-inducing activity of cytolysins, recombinant protein was constructed. Recombinant ILO exhibited significantly lower IFN-␥-inducing activity than LLO. By comparing the IFN-␥-inducing activity of a chimera incorporating LLO and ILO, it was found that domains 1 to 3 of LLO were critical for IFN-␥-inducing activity while the counterpart in ILO was unable to induce cytokine production. These results suggested that the weak ability of ILO to induce IFN-␥ production is responsible for the failure of L. ivanovii to generate effective protective immunity.Among the bacterial species belonging to the genus Listeria, two species, Listeria monocytogenes and Listeria ivanovii, are known to be pathogenic (42). L. monocytogenes causes serious infections in newborns, pregnant women, immunocompromised individuals (9,11,24), and animals (25). L. ivanovii is pathogenic to ruminants (25) but rarely causes human disease (6, 23).These two species possess a similar central virulence gene cluster consisting of prfA, plcA, hly, mpl, actA, and plcB, the transcription of which is positively regulated by PrfA (13, 21). Both listeriolysin O (LLO), an hly gene product in L. monocytogenes, and ivanolysin O (ILO), an ilo gene product in L. ivanovii, are 58-kDa secretory proteins that are the major virulence determinants in each (12,20,40). They show 80% homology in amino acid sequence (14, 16) and belong to a family of cholesterol-dependent cytolysins (CDCs) characterized by the presence of a highly conserved undecapeptide sequence (ECTGLAWEWWR) located near the C terminus (7, 42). The CDCs are known to bind cholesterol on the cell surface and form oligomers, resulting in a ring-shaped pore on the cytoplasmic membrane. The cytolytic activity of CDC is easily blocked by treatment with small amounts of free cholesterol (2). Rossjohn et al. analyzed the three-dimensional structure of perfringolysin O, a member of the CDC family produced by Clostridium perfringens, and reported that perfringolysin O consists of four domains (34). The continuous domains 1 to 3 are involved in oligomerization and insertion of the oligomer into th...

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confidence: 99%

Differences in Gamma Interferon Production Induced by Listeriolysin O and Ivanolysin O Result in Different Levels of Protective Immunity in Mice Infected with Listeria monocytogenes and Listeria ivanovii

et al. 2003

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“…The spectrum of disease is broad, ranging from asymptomatic infection and carriage to uncommon cutaneous lesions, flu-like symptoms, various focal infections such as septic arthritis, conjunctivitis, urethritis, endocarditis [3], and the more serious and better recognised conditions of septicaemia, abortion and meningoencephalitis in humans [6]. The virulence [7][8][9][10] and health risks associated with different species and strains have been discussed [11], concluding that Listeria rmonocytogenes is the species of most concern, although the haemolytic species L. seeligeri and L. icanovii are also recognised as potential pathogens [9,12].While L. ntonocytogenes has been found in silage [4], in faeces from both symptomatic and healthy individuals and animals, and at many environmental sites [5,13], the more serious manifestations of infection and invasive disease are thought generally to be the result of eating contaminated food. Elucidation of the epidemiology is nevertheless incomplete [8].…”

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Occurrence ofListeriaspecies in ready to eat foods

Wilson

1995

Epidemiol. Infect.

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SUMMARYOver 8000 ready to eat foods were examined for the presence of Listeria species.Overall, 5% of foods were found to contain these organisms. Higher occurrence was found in some foods such as chicken (11%) and fish (14%). Most of the Listeria species isolated were L. monocytogenes (49 %) and L. innocua (360%) with lower numbers of other species. No seasonal pattern in the recovery of L. monocytogenes was found. Unsatisfactory or potentially hazardous levels of L. nmonocytoqenes were found in 14 products (< 0-2%), mostly cooked meats.Undercooked chicken products appeared to present the greatest risk for the duration of this survey. The small number of samples which were potentially hazardous suggests that the risk to consumers is not high, and this is confirmed by the absence of clinical cases in the region during the period of study. INTROD)UCTIONListeria have long been recognized as the cause of a range of serious human diseases [1]. Various surveys have shown them to be carried intestinally by 5-70 % [21 and 0 5-92 % of healthy humans [3], and by many animals [4, 5]. Exposure, consumption and carriage often do not lead to development of disease. Immnunocompromised individuals including the immunosuppressed, elderly, pregnant, and those suffering a range of underlying diseases are primarily at risk. The spectrum of disease is broad, ranging from asymptomatic infection and carriage to uncommon cutaneous lesions, flu-like symptoms, various focal infections such as septic arthritis, conjunctivitis, urethritis, endocarditis [3], and the more serious and better recognised conditions of septicaemia, abortion and meningoencephalitis in humans [6]. The virulence [7][8][9][10] and health risks associated with different species and strains have been discussed [11], concluding that Listeria rmonocytogenes is the species of most concern, although the haemolytic species L. seeligeri and L. icanovii are also recognised as potential pathogens [9,12].While L. ntonocytogenes has been found in silage [4], in faeces from both symptomatic and healthy individuals and animals, and at many environmental sites [5,13], the more serious manifestations of infection and invasive disease are thought generally to be the result of eating contaminated food. Elucidation of the epidemiology is nevertheless incomplete [8]. Careful food production, cooking and

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“…L. monocytogenes is a pathogenic species in both animals and humans (McLauchlin and Jones 1999). However, in a few cases of human infections, L. ivanovii (Cummins et al 1994, Lessing et al 1994) and L. seeligeri (Rocourt et al 1986) have been incriminated as causative agents.…”

Section: Isteriosis Is a Disease Caused By Bacteria Of The Genusmentioning

confidence: 99%

Prevalence of Listeria spp. in freshwater T\s\v(Oncorhynchus my kiss and Carassius gibelio) and the environment offish markets in Northern Greece

Papadopoulos¹,

Abrahim

Sergelidis

et al. 2017

J Hellenic Vet Med Soc

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In this study, a total of 405 samples from freshwater fish, personnel and environment were collected from retail fish markets in three cities in Northern Greece and they were examined for the presence of Listeria spp. They consisted of 136 samples from the skin and 136 from the flesh of 71 rainbow trout (Oncorhynchus mykiss) and 65 gibel carps (Carassius gibelio), 20 from workers' hands, 27 from workers' knives, 22 from working surfaces, 29 from wooden boxes, 15 from plastic boxes, 18 from floor surfaces and 2 from drainage lids. Listeria spp. was isolated from 10.62% of the samples, L. monocytogenes were 0.99%, 4.69% L. seeligeri and 4.94% L. innocua, respectively. L. monocytogenes was isolated from 3.54% of the environmental samples and none from fresh water fish and workers hands' samples. Listeria spp. was isolated from 1.54% of gibel carp flesh (1.54% L. seeligeri), from 18.46% of gibel carp skin (10.77% L. seeligeri and 7.69% L. innocua) and from 8.45% from rainbow trout skin samples (1.41% L. seeligeri and 7.04% L. innocua). The higher rate of isolation of Listeria spp. from the environmental samples emphasises the importance of sanitary conditions in order to reduce the risk of contamination by L. monocytogenes at the retail level.

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Listeria ivanovii infection

Cited by 44 publications

References 5 publications

Differences in Gamma Interferon Production Induced by Listeriolysin O and Ivanolysin O Result in Different Levels of Protective Immunity in Mice Infected with Listeria monocytogenes and Listeria ivanovii

Differences in Gamma Interferon Production Induced by Listeriolysin O and Ivanolysin O Result in Different Levels of Protective Immunity in Mice Infected with Listeria monocytogenes and Listeria ivanovii

Occurrence ofListeriaspecies in ready to eat foods

Prevalence of Listeria spp. in freshwater T\s\v(Oncorhynchus my kiss and Carassius gibelio) and the environment offish markets in Northern Greece

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