Listen to your physiologist!

Exercise and cardiovascular diseases

“…However, exercise‐induced physiological adaptations described above might not necessarily be similar for persons who suffer from different CV risk factors, and personalized, supervised exercise programs should target the situation and training status of individual patients 26 . Hypertensive individuals demonstrate anomalous muscle mitochondrial turnover and amplified oxidative damage.…”

Bradykinin—from snake poison to therapeutic options

“…33 Furthermore, positive outward remodelling of preexisting collateral arteries into functional conductance arteries, arteriogenesis, is the most important endogenous rescue mechanism to prevent cardiovascular ischaemia. 34 Arteriogenesis is accompanied by the expression of kinin precursor, and kinin receptors act as positive modulators of arteriogenesis in mice and rats. Here, collateral artery growth is effectively and therapeutically stimulated by BKB1R agonists, involving a contribution of peripheral immune cells 35 (Figure 1).…”