Lissoclinotoxins E and F, Novel Cytotoxic Alkaloids from a Philippine Didemnid Ascidian.

Abstract

Alkaloids Alkaloids U 0600 Lissoclinotoxins E and F, Novel Cytotoxic Alkaloids from a Philippine Didemnid Ascidian. -The structures of title compounds (I) and (II) are determined by spectroscopic means and chemical transformation. They show potent cytotoxicity towards PTEN-deficient human breast carcinoma cell lines. -(DAVIS, R. A.; SANDOVAL, I. T.; CONCEPCION, G. P.; DA ROCHA, R. M.; IRELAND*, C. M.; Tetrahedron 59 (2003) 16, 2855-2859; Dep. Med. Chem., Univ. Utah, Salt Lake City, UT 84112, USA; Eng.) -Jannicke 32-159