Lissoclimides, Cytotoxic Diterpenes from<b>Lissoclinum voeltzkowi</b>Michaelsen

Biard, Jean-François; Malochet-Grivois, C.; Roussakis, Christos; Cotelle, Philippe; Hénichart, Jean‐Pierre; Debitus, Cécile; Verbist, Jean-François

doi:10.1080/10575639408043890

Cited by 25 publications

(29 citation statements)

References 11 publications

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“…Cytotoxicity, Inhibitors of adenosine transferase [35,68] Dysidea sp inhibiting the activity of enzyme aldose reductase [32,33,68] Halichondriidae Antifungal activity, inhibitors of phospholipase A2 [34,68,72] Lissoclinum voeltzkowi Cytotoxicity [43,44].…”

Section: Agelas Mauritianamentioning

confidence: 99%

“…A number of 9:13 prefuran ethers 17 have been found and isolated [23]. Some labdane glycerides have been also isolated from the antarctic nudibranch Austrodoris kerguelensis [42] from the marine tunicate Lissoclinum voeltzkowi (Urochordata) [43,44], from the frozen Thai sponge belonging to the genus Mycale [45] as well as from the Mediterranean sponge Raspaciona aculeata [46]. Several labdne diterpenes have been isolated from the wax exuded by the scale insect Ceroplastes pseudoceriferus (Coccidae) Hemiptera Table 3.…”

Section: Trimusculus Conica Trimusculus Reticulatusmentioning

confidence: 99%

“…Examination of the marine tunicate Lissoclinum voeltzkowi (Urochordata) gave highly cytotoxic rare succinimide, dichlorolissoclimides [43,44], while two labdanes (agelasimine A and B) isolated from the marine orange sponge Agelas mauritiana, were exhibited strong cytotoxicity, when tested against L-1210 mouse leukaemia cells in vitro (ED50=2-4µg/ml) [35,68]. Four new labdane diterpenes, 1-4 with an unusual oxidation pattern have been isolated from the marine pulmonate Trimusculus peruvianus Fig.…”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

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Labdanes of Natural Origin-Biological Activities (1981-2004)

Chinou

2005

CMC

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Terpenoids is a class of natural compounds found in higher plants, mosses, liverworts, algae and lichens, as well as in insects, microbes or marine organisms. Through centuries many of these compounds have been used as ingredients of perfumes, drugs, narcotics or pigments. Labdanes, belonging to the bicyclic diterpenoids group, have been found as secondary metabolites in tissues of fungi, insects, marine organisms, and in essential oils, resins and tissues of higher plants. The diterpenes of labdane type, have been reported to have broad spectrum of biological activities. In this study, the reported bioactivities and/or uses of them, the last two decades (1981-2004), are selected as an attempt to underline their role in nature.

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Section: Agelas Mauritianamentioning

confidence: 99%

Section: Trimusculus Conica Trimusculus Reticulatusmentioning

confidence: 99%

Section: Antimicrobial Activitiesmentioning

confidence: 99%

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Labdanes of Natural Origin-Biological Activities (1981-2004)

Chinou

2005

CMC

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“…1,2 The biological activity of these products 3 and of some derivatives prompted us to initiate their total synthesis. A method for the preparation of the diequatorial dichlorinated trimethyldecalin derivatives, analogues of the AB rings of dichlorolissoclimide, has recently been described.…”

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confidence: 99%

“…The absolute configuration of dichlorolissoclimide (2) was thus determined by X-ray crystallography as described in the Experimental Section. This analysis resulted in the unambiguous assignment of the configuration shown ( Figure 1).…”

mentioning

confidence: 99%