Lissoclibadin 1, a novel trimeric sulfur-bridged dopamine derivative, from the tropical ascidian Lissoclinum cf. badium

Liu, Hongwei; Pratasik, Silvester Benny; Nishikawa, Teruaki; Shida, Takeshi; Tachibana, Kunihide; Fujiwara, Takeshi; Nagai, Hiroshi; Kobayashi, Haruo; Namikoshi, Michio

doi:10.1016/j.tetlet.2004.07.138

Cited by 29 publications

(27 citation statements)

References 9 publications

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“…In this study, all Indonesian natural product ligands were obtained from a various study that has been conducted previously, including from HerbalDB database [32,[38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. These ligand structures were redrawn by using PerkinElmer ChemBioDraw Ultra 13.0, which can be saved later in .mol format.…”

Section: Acquiring the Indonesian Natural Product Ligands And Vp24 Prmentioning

confidence: 99%

Identification of novel Ebola virus (EBOV) VP24 inhibitor from Indonesian natural products through in silico drug design approach

Tambunan¹,

Nasution²

2017

AIP Conference Proceedings

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Sensitivity differences between microporous NaY and hierarchical ZSM-5 modified electrodes as ammonia gas sensor AIP Conference Proceedings 1862, 030081 (2017) Abstract. Ebola remains as one of the deadliest diseases in the world, with almost 29,000 cases were reported and kill 11,000 of them, and yet neither treatment nor vaccine that can combat this disease effectively. This disease is caused by ebolavirus (EBOV), a primary member of Filoviridae family. The life cycle of this virus has been operated by several key proteins, one of them is VP24 protein, which has been known for its crucial role in the transcription and replication of EBOV. Therefore, targeting VP24 protein can be a solution for treating this pathogenic disease. In this study, virtual screening of Indonesian natural products as EBOV VP24 inhibitor was performed. About 2,020 ligands from many sources, including HerbalDB database, were obtained and screened by using DataWarrior software to measure its molecular and pharmacological properties, resulting 301 ligands in the process. Then, the molecular docking simulation was performed to check the ligand's binding interaction and affinity with EBOV VP24 protein; this simulation was done by using MOE 2014.09 software. This study resulted that cycloartocarpin was the best ligand to inhibit the EBOV VP24 protein. Therefore, this ligand should be checked its stability through molecular dynamics simulation and performed in vitro test to verify its bioactivity against the EBOV VP24 protein.

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Section: Acquiring the Indonesian Natural Product Ligands And Vp24 Prmentioning

confidence: 99%

Identification of novel Ebola virus (EBOV) VP24 inhibitor from Indonesian natural products through in silico drug design approach

Tambunan¹,

Nasution²

2017

AIP Conference Proceedings

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“…Aromatic alkaloids possessing polysulfide structures have been reported from ascidians of the genera Lissoclinum, 1,2,[4][5][6][7][8][9] Eudistoma, 7) and Polycitor. 10) There is only one example of a trimer, lissoclibadin 1 (1), 1,2) and six dimeric polisulfides 2,5,8,11) and more than 10 monomeric cyclic polysulfides [4][5][6][7]9,10) have been isolated from the above ascidians.…”

Section: )mentioning

confidence: 99%

“…10) There is only one example of a trimer, lissoclibadin 1 (1), 1,2) and six dimeric polisulfides 2,5,8,11) and more than 10 monomeric cyclic polysulfides [4][5][6][7]9,10) have been isolated from the above ascidians. Various biological activities, such as antifungal activity, 2,[4][5][6]10) antibacterial activity, 2,7,10) cytotoxicity, 2,4,6,11) antimalarial (Plasmodium falciparum) activity, 6) inhibition of protein kinase C, 7,8) and inhibition of IL-8 Ra and Rb receptors 9) have been reported.…”

Section: )mentioning

confidence: 99%