Lisinopril in the composition of calcium phosphate nanoparticles as a promising antiglaucoma agent

Shimanovskaya, E. V.; Nikolskaya, I.I.; Binevskii, P. V.; Безнос, О. В.; Klyachko, N. L.; Павленко, Т. А.; Чеснокова, Н. Б.; Кост, О. А.

doi:10.1134/s1995078014020141

Cited by 10 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inorganic nanoparticles suitable for nanomedicine include gold [110][111][112][113][114] and silver [115,116] nanoparticles, cerium dioxide [117,118], silica [119,120], as well as inorganic salts [121][122][123].…”

Section: Inorganic Particlesmentioning

confidence: 99%

“…Promising carriers for drug delivery are calcium carbonate and calcium phosphate [121,122,139,[146][147][148][149][150]. This is due to the biocompatibility and biodegradability of these salts [148,151], as well as the simplicity and low cost of the synthesis [123,152].…”

Section: Particles Formed By Inorganic Saltsmentioning

confidence: 99%

“…Calcium phosphate nanoparticles were shown to be able to contain both low molecular weight and high molecular weight substances. Thus, such particles containing 316 Da β-blocker timolol [121,161], 406 Da inhibitor of angiotensin-converting enzyme, lisinopril [121,122], which is also able to decrease IOP at topical instillations [169], and 32 kDa superoxide dismutase 1 [150] were reported. The particles were further coated with a disaccharide, cellobiose [122,161], or with a polysaccharide, 89 kDa chitosan [121].…”

Section: Particles Formed By Inorganic Saltsmentioning

confidence: 99%

“…Thus, such particles containing 316 Da β-blocker timolol [121,161], 406 Da inhibitor of angiotensin-converting enzyme, lisinopril [121,122], which is also able to decrease IOP at topical instillations [169], and 32 kDa superoxide dismutase 1 [150] were reported. The particles were further coated with a disaccharide, cellobiose [122,161], or with a polysaccharide, 89 kDa chitosan [121]. The particles containing different compounds were characterized by a size of 140-300 nm [121,122,150,161].…”

Section: Particles Formed By Inorganic Saltsmentioning

confidence: 99%

“…The particles were further coated with a disaccharide, cellobiose [122,161], or with a polysaccharide, 89 kDa chitosan [121]. The particles containing different compounds were characterized by a size of 140-300 nm [121,122,150,161]. Uncoated calcium phosphate nanoparticles with encapsulated SOD1 had a negative ζpotential of about −4 mV.…”

Section: Particles Formed By Inorganic Saltsmentioning

confidence: 99%

See 4 more Smart Citations

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

Vaneev

Tikhomirova

Чеснокова

et al. 2021

IJMS

View full text Add to dashboard Cite

Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among these, nanosize carriers are the most attractive. The review is focused on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles and nanomicelles. Studies in vitro and in vivo have demonstrated that new formulations could help to improve the bioavailability of the drugs, provide sustained drug release, enhance and prolong their therapeutic action. Promising results were obtained with drug-loaded nanoparticles included in in situ gel.

show abstract