Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis

Sumigray, Kaelyn D.; Chen, Hsin-Hsin; Lechler, Terry

doi:10.1083/jcb.201104009

Cited by 74 publications

(136 citation statements)

References 43 publications

(76 reference statements)

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“…Humans have a single desmoplakin gene, which is alternatively spliced to yield desmoplakin I and desmoplakin II, with the desmoplakin II variant lacking about two-thirds of the rod domain [34]. The desmoplakin-I-specific sequences might facilitate association with microtubule binding proteins (see below and [35]), while the desmoplakin II variant appears to be particularly important in epidermal adhesion [36]. …”

Section: Desmosome Composition and Architecturementioning

confidence: 99%

“…In addition to facilitating intermediate filament attachment, Lechler and colleagues revealed for the first time that the desmosome protein desmoplakin governs the redistribution of microtubules that occurs as epidermal cells begin to stratify [35, 105]. In basal cells, microtubules are radially distributed, with minus ends emanating from perinuclear centrosomes and plus ends extending out to the membrane.…”

Section: Desmosomal Proteins In Differentiation Development and mentioning

confidence: 99%

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Structure, Function, and Regulation of Desmosomes

Kowalczyk¹,

Green²

2013

Progress in Molecular Biology and Translational Science

216

207

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Summary Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.

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Section: Desmosome Composition and Architecturementioning

confidence: 99%

Section: Desmosomal Proteins In Differentiation Development and mentioning

confidence: 99%

Structure, Function, and Regulation of Desmosomes

Kowalczyk¹,

Green²

2013

Progress in Molecular Biology and Translational Science

216

207

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“…Epidermal loss of Lis1 did not only result in a lack of cortical microtubule recruitment to desmosomes in the suprabasal layers but, surprisingly, impaired desmosomal stability (Sumigray et al 2011). The cortical localization of microtubules is also necessary to recruit myosin II that strengthens AJs, which in turn promotes TJs epidermal barrier function (Sumigray et al 2012).…”

Section: Barrier Formation and Function In The Epidermismentioning

confidence: 99%

Epidermal Polarity Genes in Health and Disease

Tellkamp

Vorhagen

Niessen

2014

Cold Spring Harbor Perspectives in Medicine

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The epidermis of the skin is a highly polarized, metabolic tissue with important innate immune functions. The polarity of the epidermis is, for example, reflected in controlled changes in cell shape that accompany differentiation, oriented cell division, and the planar orientation of hair follicles and cilia. The establishment and maintenance of polarity is organized by a diverse set of polarity proteins that include transmembrane adhesion proteins, cytoskeletal scaffold proteins, and kinases. Although polarity proteins have been extensively studied in cell culture and in vivo in simple epithelia of lower organisms, their role in mammalian tissue biology is only slowly evolving. This article will address the importance of polarizing processes and their molecular regulators in epidermal morphogenesis and homeostasis and discuss how alterations in polarity may contribute to skin disease.

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“…In basal cells microtubules form a cytoplasmic network emanating from an apical centrosome, while in suprabasal cells microtubules concentrate at cell-cell junctions. During epidermal differentiation ninein and Lis1/Ndel1, which are centrosomal proteins required for microtubule anchoring, are lost from the centrosome and is recruited to desmosomes by desmoplakin, resulting in the relocation of microtubules to the cell cortex [Lechler and Fuchs, 2007;SumiGray et al, 2011].…”

Section: Epithelial Cell Polarizationmentioning

confidence: 99%

Shaping microtubules into diverse patterns: Molecular connections for setting up both ends

Mimori-Kiyosue¹

2011

Cytoskeleton

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Microtubules serve as rails for intracellular trafficking and their appropriate organization is critical for the generation of cell polarity, which is a foundation of cell differentiation, tissue morphogenesis, ontogenesis and the maintenance of homeostasis. The microtubule array is not just a static railway network; it undergoes repeated collapse and reassembly in diverse patterns during cell morphogenesis. In the last decade much progress has been made toward understanding the molecular mechanisms governing complex microtubule patterning. This review first revisits the basic principle of microtubule dynamics, and then provides an overview of how microtubules are arranged in highly shaped and functional patterns in cells changing their morphology by factors controlling the fate of microtubule ends. V C 2011 Wiley Periodicals, Inc.

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Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis

Abstract: Desmoplakin recruits the centrosomal protein Lis1 to the epidermal cell cortex, where it regulates cortical microtubule organization and desmosome stability.

Cited by 74 publications

References 43 publications

Structure, Function, and Regulation of Desmosomes

Structure, Function, and Regulation of Desmosomes

Epidermal Polarity Genes in Health and Disease

Shaping microtubules into diverse patterns: Molecular connections for setting up both ends

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