Liraglutide overdose: A case report and an updated review

Nafisah, Sharafaldeen Bin; Almatrafi, Daliah; Al-Mulhim, Khalid Abdulmohsen

doi:10.4103/2452-2473.276386

Cited by 5 publications

(2 citation statements)

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“…A recent case report of autopsy demonstrated pathologic pancreatic changes in patients with diabetes who were treated with incretin-based drugs such as Liraglutide [5]. Furthermore, a recent meta-analysis had near-unanimous reporting of adverse gastrointestinal symptoms suggestive of pancreatitis, but there was no formal diagnosis of acute pancreatitis in the acute phase of illness or in the follow-up period [4][5][6][7][8][9][10][11][12][13][14][15][16]. Given these considerations, future research, and evaluation of the short-and long-term consequences of GLP-1RA use and overdose are highly recommended [17].…”

Section: Discussionmentioning

confidence: 99%

“…Reports of hypoglycemic episodes are rare [ 3 ]. Pancreatitis is a suspected side-effect of GLP-1 RAs; however, few studies and case reports of GLP-1 RA overdose and its association with acute pancreatitis have been described [ 4 ]. A recent case report of autopsy demonstrated pathologic pancreatic changes in patients with diabetes who were treated with incretin-based drugs such as Liraglutide [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Liraglutide Overdose-Induced Acute Pancreatitis

AlSaadoun¹,

AlSaadoun²,

Ghumlas³

2022

Cureus

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Liraglutide, a long-acting cardioprotective glucagon-like peptide (GLP)-1 analog, is effective for medical weight loss and glycemic control in type 2 diabetes. It is generally well tolerated with mild side effects. There are few reports on complications from Liraglutide overdose. The aim of this paper is to report the case of a 25-year-old healthy female who presented with acute pancreatitis secondary to Liraglutide overdose and to review the current literature on Liraglutide used for obesity management. The current literature examining the association between acute pancreatitis and Liraglutide use, and Liraglutide overdose are inconclusive. Further research is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Liraglutide Overdose-Induced Acute Pancreatitis

AlSaadoun¹,

AlSaadoun²,

Ghumlas³

2022

Cureus

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GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience

Marshall,

Ryan,

Rivera

et al. 2024

J. Med. Toxicol.

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Introduction Glucagon-like peptide-1 receptor agonist use has increased over the last decade for glycemic control in type 2 diabetes mellitus, cardiovascular risk reduction, and weight loss. Clinical trials indicate that gastrointestinal adverse effects are commonly experienced and severe hypoglycemia is rare; however, there is little data regarding glucagon-like peptide-1 receptor agonist in overdose. Methods We performed a retrospective chart review evaluating and characterizing glucagon-like peptide-1 receptor agonist exposures reported to a single poison center between 2006 and 2023. Patient demographics, circumstances of exposure, clinical effects, and outcomes were abstracted from charts. Descriptive statistics were utilized to summarize demographic information and clinical factor data. Results A total of 152 charts met inclusion criteria. Therapeutic errors accounted for 91% of exposures. Most patients (67%) reported no symptoms, although not all patients were followed to a definitive outcome. Nausea, vomiting, generalized weakness, and abdominal pain were the predominant symptoms reported. Most patients (62%) were monitored and closely followed in the home setting. Hypoglycemia was rare but occurred in the setting of a single agent glucagon-like peptide-1 receptor agonist exposure in two patients. Two additional patients who developed hypoglycemia involved co-administration of insulin. 21% of the exposures were related to errors on initial use of the pen. Conclusion Exposures to glucagon-like peptide-1 receptor agonist have increased substantially over the years. Effects from an exposure tended to be mild and primarily involve gastrointestinal symptoms. Hypoglycemia was rare. Therapeutic and administration errors were common. Education on pen administration may help to reduce errors.

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Liraglutide/octreotide

2021

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Liraglutide overdose: A case report and an updated review

Cited by 5 publications

References 0 publications

Liraglutide Overdose-Induced Acute Pancreatitis

Liraglutide Overdose-Induced Acute Pancreatitis

GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience

Liraglutide/octreotide

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