Liraglutide-induced injection site reaction

“…4 Injection site reactions include hemorrhage, deep nodular infiltrate, and pruritic erythematous macules. 5 , 6 Only a single case of delayed hypersensitivity to liraglutide has been published, confirmed by a skin test. 7 We would recommend intradermal test as a first-line test in the diagnosis of cases with suspected delayed liraglutide hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Delayed type hypersensitivity injection site reaction and tolerance induction to liraglutide for the treatment of obesity

Yaneva¹,

Handjieva‐Darlenska²,

Kazandjieva³

et al. 2023

JAAD Case Reports

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“…In addition to these CADRs, two cases related to the drug's injection site were noted. The first involved a 35-year-old woman who presented with erythematous well-defined plaques surrounded by ecchymotic patches on the extensor surfaces of her thighs at the injection site [47]. The second case demonstrated exenatideinduced eosinophilic sclerosing lipogranuloma forming at the injection site of a 62-year-old patient [48].…”

Section: Glucagon-like Peptide-1 Receptor Agonistsmentioning

confidence: 99%

Cutaneous Reactions to Antidiabetic Agents: A Narrative Review

Boccardi

Shubrook

2022

Diabetology

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Diabetes is a common and complex disease affecting multiple organ systems throughout the body. With a consensus in care guidelines emphasizing the importance of glycemic control in determining the disease progression, people with diabetes worldwide have been placed on medication regimens targeting glucose stability from a variety of pathophysiologic pathways. Each of these medications also possesses its own potential for adverse events. In recent years, there has been increased reports of skin reactions to diabetes medications, adding to the more widely known eruptions such as insulin-induced lipohypertrophy and contact dermatitis of subcutaneous injections. The authors searched PubMed, Google, and Embase for articles including adverse reactions to anti-hyperglycemic medications. Key words and titles searched included, “antidiabetic drugs”, “skin reactions”, “adverse drug reactions”, “allergic reactions”, “diabetes”, “metformin”, “insulin”, “DPP4 inhibitors”, “thiazolindineones”, “sulfonylureas”, “SGLT2 inhibitors”, “GLP-1 agonists”, “diabetic medication”, “injection site reactions”. As a result, a total of 59 papers are included in this review. The great majority were case reports ranging from benign fixed drug eruptions to severe cutaneous reactions that threaten patients’ lives. Increasing physician awareness of both the potential for, and presentation of, such reactions to diabetes medications can reduce hospitalizations and optimize care in an already vulnerable patient population.

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Liraglutide-induced injection site reaction

Cited by 9 publications

References 0 publications

Delayed Hypersensitivity Reaction to Liraglutide: A Case Report

Delayed Hypersensitivity Reaction to Liraglutide: A Case Report

Delayed type hypersensitivity injection site reaction and tolerance induction to liraglutide for the treatment of obesity

Cutaneous Reactions to Antidiabetic Agents: A Narrative Review

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