Liraglutide improves surfactant protein-B production and reduces right ventricular hypertrophy in a rat model of intersitial pulmonary fibrosis

Gomez, Juan Fandino; Perez, Marina Romani; Iglesias, Veronica Outeirino; Diz-Chaves, Yolanda; Nunez, Maria; Dab, Houcine; Gago, Eva MariaVigo; Matias, Lucas Gonzalez; Ferrer, Federico Mallo

doi:10.1530/endoabs.37.ep620

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“…Our data showed that liraglutide was able to significantly decrease CTGF mRNA expression in kidney tissue compared to the diabetic group reaching to nonsignificant level in comparison to control group. Previously, liraglutide administration to STZ‐diabetic rats was able to reserve right ventricular hypertrophy and to have some positive effects in lung and cardiopulmonary functions through decreasing the expression of CTGF mRNA in myocardial tissue which may highlight the importance of liraglutide in diabetic patients and the evaluation of tissue GLP‐1 receptor distribution.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of liraglutide on expression of CTGF and BMP‐7 in induced diabetic nephropathy

Ramzy

Abdalla

Zenhom

et al. 2019

J of Cellular Biochemistry

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Introduction Diabetic nephropathy (DN) is one of the critical complications of diabetes mellitus and the main cause of chronic renal dysfunction. The pathogenic mechanism causing the disease remains unclear and there is a lack of effective treatment methods so novel strategies are needed for DN management. The aim of this study, therefore, is to evaluate the effect of liraglutide as glucagon‐like peptide‐1 analogue and its underlying mechanisms on induced DN in rats Materials and Methods Sixty rats were divided into control group, diabetic group, and liraglutide‐treated group. At the end of experiment, renal CTGF and BMP‐7 messeger RNA expression were determined. Blood sugar, serum urea, and creatinine were measured. Also, histopathological changes were studied. Results Liraglutide can improve renal alterations associated with diabetes as it reduced CTGF expression and increased BMP‐7 expression. In the same time, it could improve histopathological changes and renal function tests. Conclusion These findings influence the beneficial use of liraglutide for the management of DN in patients with diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%