Liquordruck und Liquorchemismus vor und nach Entfernung großer Liquormengen und deren Beeinflußbarkeit durch Pharmaca

Haug, Karl; Göttke, Leonhard

doi:10.1007/bf01814317

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…While such measurements can signal impending clinical deterioration, they d o not provide quantitation of the parameters of resistance and compliance that would define the reserve capacity of the system at any given stage of a disease process. In an effort to derive such data in experimental animals and man, manometric infusion techniques were introduced by Haug and RAT Gottke in 1933 [18] [35], requires controlled introduction of fluid into the lumbar subarachnoid space at varying rates in association with continuous monitoring of CSF pressure. Although pressure monitoring at relatively high rates of intrathecal infusion may be qualitatively helpful in certain clinical situations, such measurements have not provided quantitative statements of both resistance and compliance.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of intracranial pressure in rat, dog, and man

Mann

Butler

Rosenthal

et al. 1978

Annals of Neurology

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Intracranial resistance and compliance were assessed in the cerebrospinal fluid system of rat, dog, and man by means of low-volume, short-duration infusions of artificial CSF into the subarachnoid space. A family of pressure/time response curves was obtained for each species: at low flow rates, steady-state pressure elevations were associated with normal neurological function; at high flow rates, rapid linear pressure elevations were associated with marked neurological dysfunction. From these curves a mathematical model was developed which describes transport and pressure-dependent valvelike characteristics of the CSF outflow resistance. This resistance shows a progressive phylogenetic change in rat, dog, and man which increasingly enhances the species' abilities to vent fluid from the intracranial cavity into the venous circulation. Arachnoid villi appear to be the major structures modulating sustained, nonlethal elevations of intracranial pressure.

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Section: Discussionmentioning

confidence: 99%

“…Gottke in 1933 [18] Through measurement of the flow-dependent pressure responses to a series of constant-rate infusions, a comprehensive evaluation of intracranial reserve in terms of resistance and compliance can be obtained.…”

Section: Ratmentioning

confidence: 99%

Regulation of intracranial pressure in rat, dog, and man

Mann

Butler

Rosenthal

et al. 1978

Annals of Neurology

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“…The clinical use of the lumbar subarachnoid constant infusion manometric test in evaluating the absorptive capacity of cerebrospinal fluid was proposed by Katzman and Hussey (1970), who elaborated on previous observations on the use of tnis technique (Haug and Gottke 1933, Schaltenbrand and Wordehoff 1947, Foldes and Arrowood 1948, Ryder et al 1953. Since then, the test has been widely used as a diagnostic aid in determining indications for surgery in hydrocephalic patients (Hussey et al , Nelson and Goodman 1971, Martins 1973, Wolinski et d. 1973, Trotter et al 1974, Belloni et al 1976).…”

Section: Introductionmentioning

confidence: 99%

Lumbar Subarachnoid Infusion Test in Paediatric Neurosurgery

Caldarelli¹,

Rocco²,

Gf³

1979

Develop Med Child Neuro

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SUMMARY Cerebrospinal fluid (CSF) absorption was studied in 59 children by the lumbar subarachnoid constant infusion manometric test. The patients were divided into three groups on the basis of the clinical and neuroradiological findings: hydrocephalus (28 cases), cerebral atrophy (21 cases) and craniosynostosis and microcephaly (10 cases). Results suggesting severe impairment in CSF absorption were obtained in all the children with hydrocephalus under tension. Conversely, the test was normal in all children with cerebral atrophy, and in postoperative tests on hydrocephalic children whose CSF shunts were functioning satisfactorily. A moderate deficit in CSF absorption was demonstrated by some hydrocephalic children, namely those with a slowly progressive ventricular dilatation. Defective CSF absorption in the low‐pressure range but normal in the high ranges was found in children with multiple suture craniosynostosis. RÉSUMÉ Le test de perfusion lombaire sous arachnoidienne en pratique pédiatrique neurochirurgicale L'absorption du liquide céphalorachidien (LCR) a étéétudiée chez 59 enfants par le test manométrique de perfusion permanente lombaire sous arachnoidienne. Les sujets ont été divisés en trois principaux groupes sur la base des données cliniques et neuroradiologiques; hydrocephalic (28 cas), atrophie cerebrale (21 cas) et craniosténose et microcéphalie (10 cas). Les résultats suggèrant une altération grave de l'absorption du LCR ont été obtenus chez tous les enfants avec hydrocéphalic hypertensive; inversement, le test a été normal chez tous les enfants avec atrophie cérébrale et les hydrocéphales opérés avec un fonctionne‐ment satisfaisant du shunt. Un déficit modéré de l'absorption du LCR a été mis en évidence chez quelques hydrocéphales notamment ceux qui présentaient une dilatation ven‐triculaire lentement progressive. Une absorption de LCR, déficient au niveau des basses pressions et normale dans les hautes pressions, a été trouvée chez les enfants a craniosynostoses sur de nombreuses sutures. ZUSAMMENFASSUNG Infusionstest in den lumbalen Subarachnoidalraum in der pädiatrisch‐neurochirurgischen Praxis Bei 59 Kindern wurde die liquorabsorption durch eine kontinuierliche Infusion in den lumbalen Subarachnoidalraum unter gleichzeitiger Druckmessung untersucht. Die Patienten wurden aufgrund der klinischen und neuroradiologischen Befunde in drei Hauptgruppen eingeteilt: Hydrocephalus (28 Patienten); cerebrale Atrophie (21 Patient‐en); und Nahtsynostose und Mikrocephalie (10 Patienten). Die Ergebnisse von alien Kindern mit hypertonem Hydrocephalus weisen auf eine schwere Stöning der Liquorabsorption hin; dagegen waren die Untersuchungen bei alien Kindern mit cerebraler Atrophie und bei hydrocephalen Patienten mit ausreichend funktionierendem Shunt normal. Bei einigen hydrocephalen Kindern, besonders bei denen mit einer langsam progressiven Ventrikelvergrösserung, Hess sich eine leichte Einschränkung der Liquorabsorption nachweisen. Bei den Kindern mit kombinierter Nahtsynostose war die Liquorabsorption im ...

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Liquor cerebrospinalis

Lüthy¹

1953

Neurologie

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Liquordruck und Liquorchemismus vor und nach Entfernung großer Liquormengen und deren Beeinflußbarkeit durch Pharmaca

Cited by 9 publications

References 34 publications

Regulation of intracranial pressure in rat, dog, and man

Regulation of intracranial pressure in rat, dog, and man

Lumbar Subarachnoid Infusion Test in Paediatric Neurosurgery

Liquor cerebrospinalis

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