Liquisolid technique to enhance and to sustain griseofulvin dissolution: Effect of choice of non-volatile liquid vehicles

Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil

“…The flowable liquid retention potential was calculated using the following equation: $\begin{array}{c}\phi \text{-Value}=\frac{\text{Weight}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{of}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{nonvolatile}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{liquid}}{\text{Weight}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{of}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{carrier}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{or}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{coat}}.\end{array}$ Each admixture has specific φ -values which were determined and plotted against respective measured angle of slide for all nonvolatile liquid vehicles. The φ -value that corresponds to an angle of slide of 33° was reported to represent the flowable liquid retention potentials of powder admixtures [9]. …”

Liquisolid systems and aspects influencing their research and development

“…This P-glycoprotein decreases the drug intestinal absorption by efflux transportation and hence reduces its plasma concentration (18,(49)(50)(51)(52). Also Kollicoat ® SR 30D (polyvinyl acetate stabilized with polyvinylpyrrolidone and sodium lauryl sulphate) can be used as a liquid vehicle in liquisolid systems for controlled drug release (52,53).…”

“…The effect of the liquid load factor on tablet hardness was also proved by evaluating liquisolid tablets containing griseofulvin as a model drug. The formulation with a lower liquid load factor showed higher hardness, which may be caused by the high concentration of Avicel ® PH 102 (carrier) leading to plastic deformation of the powder admixture and formation of more hydrogen bonds between its molecules (53).…”

“…The advantages of liquisolid systems to be used in prolonged release systems include simplicity, low cost and suitability for industrial production (92). However, only a few drugs (propranolol HCl (35), theophylline (36), griseofulvin (53) and tramadol HCl (33) have been formulated as liquisolid systems with prolonged drug release.…”

“…hydroxypropyl methylcellulose) (53,92). Gonjari et al (33) proved that addition of HPMC to hydrophilic carrier (Avicel PH 102) prolonged tramadol hydrochloride release from liquisolid tablets.…”