Liquisolid pellets: Mixture experimental design assessment of critical quality attributes influencing the manufacturing performance via extrusion-spheronization

Fonseca, Aline Benedita dos Santos; Beringhs, André O’Reilly; Ferraz, Humberto Gomes; Stulzer, Hellen Karine; Sonaglio, Diva; Pezzini, Bianca Ramos

doi:10.1016/j.jddst.2020.101630

Cited by 7 publications

(16 citation statements)

References 31 publications

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“…The transparent drug solution was diluted with methanol before being examined by a UV spectrophotometer (Shimadzu Corp., Japan) at 365 cm and 470 cm for QUE and RIF, respectively. Three copies of each sample were analyzed [20][21][22][23][24][25].…”

Section: Saturation Solubility Studymentioning

confidence: 99%

“…The independent variables were Tween 20, PEG 200, and propylene glycol (X1, X2, and X3). The response variables for both medications' solubility in mg/ml and their percentage CDR at 60 minutes in 0.1 M hydrochloric acid were selected because they were viewed as crucial elements for Liqui-solid Compact to improve oral absorption of the poorly water-soluble drug [20][21][22][23][24][25].…”

Section: Screening Of Non-volatile Vehicle and Optimization Using D-o...mentioning

confidence: 99%

“…The surplus liquid that was left on the carrier material's surface is further absorbed by the coating layer, leaving the entire system dry and free-flowing. The liquisolid approach has produced encouraging results for a variety of medications [20][21][22][23][24][25]. Therefore, the Liquisolid compacts that contain insoluble pharmaceuticals encourage dissolution by facilitating the wetting process by increasing the net effective surface area, which leads to an increase in the availability of the drug for dissolution media [20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…The liquisolid approach has produced encouraging results for a variety of medications [20][21][22][23][24][25]. Therefore, the Liquisolid compacts that contain insoluble pharmaceuticals encourage dissolution by facilitating the wetting process by increasing the net effective surface area, which leads to an increase in the availability of the drug for dissolution media [20][21][22][23][24][25]. A semi-synthetic antibiotic called rifampicin is made from Streptomyces mediterranei.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Tandel¹,

Patel²,

Thakkar³

et al. 2022

Int J Pharm Res Allied Sci

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The major objective of this study is to create rifampicin and quercetin-containing liquisolid compacts with improved gastrointestinal absorption and dissolving properties. Propylene glycol, PEG 200, and Tween 20 were chosen as ideal non-volatile liquid carriers to create the required formulations because of their increased drug solubility. In an attempt to create a free-flowing, compressible powder, the liquisolid formulations were then combined with a carrier and coating material. In order to create liquisolid powders with good flow qualities, Avicel pH-102, Aeroperl 200, and Aerosil 200 demonstrated good liquid retention potential values, demonstrating their efficiency as solid carrier and coating materials in the creation of liquisolid compacts. The medication and carrier had no discernible interaction, according to FT-IR spectra. The DSC and PXRD experiments proved that the crystalline form of the medication was absent from the liquisolid powders. Furthermore, the improved drug dissolving performance in liquisolid systems revealed that the drug had changed into a molecular or amorphous state. In-vivo rat pharmacokinetic investigations revealed the ability of non-volatile liquid carriers of liquisolid systems to enhance drug absorption from formulation and enhance the gastrointestinal absorption and dissolving rate of rifampicin and quercetin.

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Section: Saturation Solubility Studymentioning

confidence: 99%

Section: Screening Of Non-volatile Vehicle and Optimization Using D-o...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Tandel¹,

Patel²,

Thakkar³

et al. 2022

Int J Pharm Res Allied Sci

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show abstract

“…A ratio greater than 4 is desirable, indicating that the regression model is sufficient to navigate the design space. [49][50][51] Adequate precisions of 24.83 and 15.69 were obtained for the reduced cubic oleic acid conversion model and reduced quadratic selectivity model as shown in Tables 6 and 7, respectively. This indicates that the two models can be used to navigate the design.…”

Section: Analysis Of Variance and Regression Models Developmentmentioning

confidence: 99%

Hydroprocessing of oleic acid for production of jet fuel range hydrocarbons over Sn(1)‐Fe(3)‐Cu(13)/SiO₂‐Al₂O₃ catalyst: Process parameters optimization, kinetics, and thermodynamic study

Ayandiran

Boahene

Dalai

et al. 2021

Asia-Pacific J Chem Eng

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Hydroprocessing of vegetable oil to high‐quality jet fuel range hydrocarbons (HRJ) plays a significant role in the development of completely interchangeable substitute for conventional petroleum‐derived jet fuel and has drawn the attention of aviation experts due to its capacity to mitigate greenhouse gas emissions associated with the aviation industry. The limited performance of 1 wt. % Sn promoted Fe(3)‐Cu(13)/SiO2‐Al2O3 catalyst in our previous study has been attributed to the successive consideration of one variable at a time in its evaluation. Maximization of oleic acid conversion and selectivity of jet fuel range hydrocarbons from hydroprocessing of oleic acid over 1 wt. % Sn promoted Fe(3)‐Cu(13)/SiO2‐Al2O3 catalyst with the best combination of the process parameter involved via multivariate approach, and evaluation of kinetic and thermodynamic activation parameters is the focus of this study. Reduced cubic oleic acid conversion model and reduced quadratic jet fuel range hydrocarbons selectivity model of high significance levels, adequate precision, and high correlation coefficient were developed. Reaction temperature of 339.5°C, 1.6 MPa H2 pressure, 6.2 wt.% catalyst concentration, and 8.0 h reaction time were optimum process parameters that can maximize oleic acid conversion and selectivity of jet fuel range hydrocarbons at 98.2% and 82.2%, respectively. This process was found to be endothermic, irreversible, and nonspontaneous with 45.8 KJ/mol activation enthalpy of reaction, 0.25 KJ/mol entropy of reaction, and the reaction's Gibb's free energy of 198.8 KJ/mol at 340°C. The minimum energy required for the reaction to take place was evaluated as 50.7 KJ/mol.

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Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing

et al. 2021

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Liquisolid pellets: Mixture experimental design assessment of critical quality attributes influencing the manufacturing performance via extrusion-spheronization

Cited by 7 publications

References 31 publications

Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Hydroprocessing of oleic acid for production of jet fuel range hydrocarbons over Sn(1)‐Fe(3)‐Cu(13)/SiO₂‐Al₂O₃ catalyst: Process parameters optimization, kinetics, and thermodynamic study

Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing

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Liquisolid pellets: Mixture experimental design assessment of critical quality attributes influencing the manufacturing performance via extrusion-spheronization

Cited by 7 publications

References 31 publications

Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Formulation and Optimization of Rifampicin and Quercetin Laden Liquisolid Compact: In-Vitro and In-Vivo Study

Hydroprocessing of oleic acid for production of jet fuel range hydrocarbons over Sn(1)‐Fe(3)‐Cu(13)/SiO2‐Al2O3 catalyst: Process parameters optimization, kinetics, and thermodynamic study

Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing

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Product

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Hydroprocessing of oleic acid for production of jet fuel range hydrocarbons over Sn(1)‐Fe(3)‐Cu(13)/SiO₂‐Al₂O₃ catalyst: Process parameters optimization, kinetics, and thermodynamic study