Abstract-A sensing platform for measuring volumetric properties of liquid samples using phononic crystals is presented in this paper. The proposed sensor concept is based on the transmission of elastic and acoustic waves through solids and liquids respectively to gather relevant information about the properties of the liquid under test. A major difference between this concept and the majority of current resonant sensors, like the well-known quartz crystal microbalance, is that the acoustic spectrometer proposed measures bulk properties and not interfacial properties of the liquid. The sensing platform uses a disposable analyte container to facilitate the measurement of hazardous substances and enable its use in biomedical applications. An electronic characterization system based on the acquisition of three mixed signals was developed to obtain the frequency response of the designed sensor. Finally, experimental and theoretical realizations were performed, using different analytes and showing characteristic transmission features that can be used as measures to determine the physical value speed of sound.