Liquid Scintillation Counters

Reynolds, George T.; Harrison, F. B.; Salvini, G.

doi:10.1103/physrev.78.488

Cited by 129 publications

(23 citation statements)

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“…Development of liquid scintillation counting started in 1950 (Reynolds et al 1950), and specifically for 14 C in 1954 (Arnold 1954), almost simultaneously with gas counting techniques. It was natural that the first system was developed in the Libby laboratory (Arnold 1954).…”

Section: Scintillation Cocktailmentioning

confidence: 99%

Developments in Radiocarbon Technologies: From the Libby Counter to Compound-Specific AMS Analyses

2009

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Section: Scintillation Cocktailmentioning

confidence: 99%

Developments in Radiocarbon Technologies: From the Libby Counter to Compound-Specific AMS Analyses

2009

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“…In short, this technique, the basis of which was discovered by Kallmann and Reynolds [41,42], is based on the transfer of energy that is emitted due to radioactive decay via aromatic hydrocarbons and a scintillator in a scintillation cocktail into photons and subsequently into electrons which can be amplified and counted. To be analyzed with this technique, a sample should be clear, colorless and homogenous.…”

Section: Analysis Of Total Radioactivitymentioning

confidence: 99%

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology

Dubbelman¹,

Rosing

Schellens

et al. 2011

Bioanalysis

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Clinical mass balance studies aim to investigate the absorption, distribution, metabolism and excretion (ADME) of a(n) (often radiolabeled) drug, following a single administration to humans. They are perfectly suited to determine the disposition and major metabolic pathways of a drug, the exposure to the parent drug and its metabolites, and the rate and route of elimination. A mass balance study, however, poses interesting challenges to the analysis of parent drug and metabolites in different biological matrices. Using recent clinical mass balance studies in oncology as an example, this review focuses on the aspects of mass balance studies, from bioanalytical assay development, analysis of clinical samples to reporting of study results. Along the way, it discusses bioanalytical problems and practical solutions.

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“…C'est le cas de la scintillation liquide développée depuis les années 1950 (Kallman, 1950 ;Reynolds et al, 1950) avec l'emploi d'un cocktail scintillant dont le rôle est de convertir l'énergie déposée par les électrons en photons détectés par un photomultiplicateur. Les techniques chromatographiques sont employées en amont de la mesure pour extraire et concentrer les radionucléides.…”

Section: Méthodes Classiques Employées Pour La Mesure Des éMetteurs βunclassified

Spectrométrie bêta appliquée aux mesures de la radioactivité dans l’environnement

et al. 2005

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Liquid Scintillation Counters

Cited by 129 publications

References 1 publication

Developments in Radiocarbon Technologies: From the Libby Counter to Compound-Specific AMS Analyses

Developments in Radiocarbon Technologies: From the Libby Counter to Compound-Specific AMS Analyses

Bioanalytical Aspects of Clinical Mass Balance Studies in Oncology

Spectrométrie bêta appliquée aux mesures de la radioactivité dans l’environnement

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