Liquid nitrogen cryotherapy on <i>Leishmania donovani</i> cutaneous leishmaniasis

Ranawaka, Ranthilaka R.; Weerakoon, Hema S; Opathella, Nandimithra

doi:10.3109/09546631003762654

Cited by 30 publications

(26 citation statements)

References 15 publications

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“…Until recent years, this has been a neglected disease locally and was thought to be a disease of military personnel (6,7). Recent literature (10,11,13,14) showed that this was a disease of locals, where farmers and children who engaged in outdoor activities were the mostly affected. With increased case finding and identification of this disease, it became an important public health problem.…”

Section: Introductionmentioning

confidence: 99%

Knowledge on Leishmaniasis among Health Care Workers In Endemic Area

Weerakoon¹,

Ranawaka

Bandara³

et al. 2016

Anuradhapura Med. J.

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Section: Introductionmentioning

confidence: 99%

Knowledge on Leishmaniasis among Health Care Workers In Endemic Area

Weerakoon¹,

Ranawaka

Bandara³

et al. 2016

Anuradhapura Med. J.

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“…Therefore, treatment must be non‐toxic and must result in a cosmetic appearance superior to that of natural healing. During the period of the present study, intralesional sodium stibogluconate (SSG) and liquid nitrogen cryotherapy were widely used as therapies for CL in Sri Lanka.…”

Section: Introductionmentioning

confidence: 99%

Randomized, double‐blind, controlled, comparative study on intralesional 10% and 15% hypertonic saline versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis

Ranawaka¹,

Weerakoon²,

Silva

2015

Int J Dermatology

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This study found 10% HS to be an effective and safe alternative to SSG. Treatment with HS at concentrations of 15% or above was not safe as a result of cutaneous necrosis. Safety was not studied for concentrations of 11-14%, and these concentrations should be avoided pending further evidence. Hypertonic saline is very cheap (< US$1 per 100 ml, whereas SSG is priced at US$160 per 100 ml), is prepared locally and has no systemic side effects and minimal local side effects.

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“…It causes mild and transient side effects (pain, hypopigmentation) and has excellent cosmetic results, which was confirmed by our observation. [9][10][11][12]…”

Section: Therapeutic Aspectmentioning

confidence: 99%

Cutaneous Leishmaniasis – Dermoscopic Findings And Cryotherapy

Dobrev¹,

Nocheva²,

Vuchev

et al. 2015

Folia Medica

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We present a 60-year-old male patient who, three months after a holiday in Southern Greece, found a small 'pimple' on his back, which gradually got as big as a small walnut, the central part becoming ulcerated and scabby. Dermatological examination found an erythematous-to-livid nodular lesion on the right shoulder; it was 16 mm in diameter with central ulceration, covered with brownish crust which discharged pus-like secretion upon pressure. Microscope examination of Romanowsky-Giemsa stained lesion material detected amastigote forms of Leishmania tropica. The culture investigation and serological tests for leishmaniasis were negative. Dermoscopy of the lesion found the following features: erythema, hyperkeratosis, central ulceration covered with brownish crust, "yellow tears-like" structures and "white starburst-like" patterns, and various vascular structures (including dotted vessels, comma-shaped vessels, hairpin- and glomerular-like vessels). The patient was diagnosed with cutaneous leishmaniasis and underwent four cryotherapy sessions every other week with excellent therapeutic results - complete resolution of infiltrate with subsequent gentle hypopigmented scarring. In conclusion, dermoscopy is an easily accessible non-invasive method which can be useful for the diagnosis of cutaneous leishmaniasis. Cryotherapy is the treatment of choice for single skin lesions.

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Liquid nitrogen cryotherapy on Leishmania donovani cutaneous leishmaniasis

Cited by 30 publications

References 15 publications

Knowledge on Leishmaniasis among Health Care Workers In Endemic Area

Knowledge on Leishmaniasis among Health Care Workers In Endemic Area

Randomized, double‐blind, controlled, comparative study on intralesional 10% and 15% hypertonic saline versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis

Cutaneous Leishmaniasis – Dermoscopic Findings And Cryotherapy

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