Liquid-Infused Surfaces: A Review of Theory, Design, and Applications

Villegas, Martin; Zhang, Yuxi; Jarad, Noor Abu; Soleymani, Leyla; Didar, Tohid F.

doi:10.1021/acsnano.9b04129

Cited by 298 publications

(266 citation statements)

References 135 publications

(379 reference statements)

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“…These are composite substrates constructed by infusing rough, textured or porous materials with wetting lubricants [16][17][18] , which are known for their 'slippery' properties. They have also been shown to exhibit a number of other advantageous surface properties, including anti-biofouling, anti-icing and self-healing [19][20][21] . Importantly, in all cases reported to date, including existing works on liquid-infused surfaces, droplet motion on surfaces with texture/topographical gradients is always uni-directional towards the denser solid fraction area, where the textures are more closely packed.…”

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confidence: 99%

Bidirectional motion of droplets on gradient liquid infused surfaces

et al. 2020

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The current paradigm of self-propelled motion of liquid droplets on surfaces with chemical or topographical wetting gradients is always mono-directional. In contrast, here, we demonstrate bidirectional droplet motion, which we realize using liquid infused surfaces with topographical gradients. The deposited droplet can move either toward the denser or the sparser solid fraction area. We rigorously validate the bidirectional phenomenon using various combinations of droplets and lubricants, and different forms of structural/topographical gradients, by employing both lattice Boltzmann simulations and experiments. We also present a simple and physically intuitive analytical theory that explains the origin of the bidirectional motion. The key factor determining the direction of motion is the wettability difference of the droplet on the solid surface and on the lubricant film.

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confidence: 99%

Bidirectional motion of droplets on gradient liquid infused surfaces

et al. 2020

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“…[8][9][10] The level of expression in plasma typically reflects severity of the disease, their nonwetting properties to different fluids. [36][37][38][39] This property is caused by a slippery or low surface tension interface between a monolayer of lubricant, locked into a porous or rough surface and the biofluid or immiscible liquid to be repelled. [40] The omniphobic LIS technology has been employed for antibacterial applications, as well as medical implants and devices where thrombosis and infections could pose a threat; [41][42][43][44] however, they have not been implemented as blocking agents for biosensing and we hypothesize that the superior repellency offered by such slippery surfaces may prove to decrease LOD for IL-6 detection in complex fluids.…”

Section: Introductionmentioning

confidence: 99%

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Shakeri

Jarad

Terryberry³

et al. 2020

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Recent studies have shown a correlation between elevated interleukin 6 (IL-6) concentrations and the risk of respiratory failure in COVID-19 patients. Therefore, detection of IL-6 at low concentrations permits early diagnosis of worstcase outcome in viral respiratory infections. Here, a versatile biointerface is presented that eliminates nonspecific adhesion and thus enables immunofluorescence detection of IL-6 in whole human plasma or whole human blood during coagulation, down to a limit of detection of 0.5 pg mL −1. The sensitivity of the developed lubricant-infused biosensor for immunofluorescence assays in detecting low molecular weight proteins such as IL-6 is facilitated by i) producing a bioink in which the capture antibody is functionalized by an epoxy-based silane for covalent linkage to the fluorosilanized surface and ii) suppressing nonspecific adhesion by patterning the developed bioink into a lubricant-infused coating. The developed biosensor addresses one of the major challenges for biosensing in complex fluids, namely nonspecific adhesion, therefore paving the way for highly sensitive biosensing in complex fluids. where significantly elevated levels indicate aggressive tumor growth or viral load and poor prognosis in patients. [2,10] Additionally, IL-6 is an important anti-inflammatory cytokine that induces acute responses in chronic inflammatory pathologies. As such, there has been an increasing interest in the use of IL-6 as a biomarker for the diagnosis of early stages of viral infections, cancer, and chronic inflammation. [9-11] A practical IL-6 biosensor should provide a low limit of detection (LOD) (≤5 pg mL −1) and acceptable linear dynamic range (1-100 pg mL −1) in complex fluids, in addition to accuracy, facile operation, and amenable to mass production. [11,12] There are a large number of different IL-6 detection techniques that have been reported in the literature including electrochemical sensors, [13-22] surface plasmon resonance (SPR), [23-25] chemiluminescence immunoassay (CLIA), [26-29] and immunofluorescence assays (IFA), [30-33] Utilizing 0-and 1-D materials such as carbon nanotubes (CNTs), [14,16] nanoparticles and nanowires, [13,19] as well as porous nanoparticles, [15] optical fibers, [32] and microfluidic platforms, [28] have enabled higher sensitivity in IL-6 detection and to date, electrochemical methods have proven to be the most promising candidate for detection of IL-6 at very low concentrations (0.33 pg mL −1 in buffer) with a wide linear dynamic range. [22] While reported IL-6 biosensors have demonstrated satisfactory LODs in buffer or processed serum, their performance in human whole plasma declines significantly, leading to higher LOD's and/or false positive results. In electrochemical sensors, for example, the nonspecific attachment of biological entities in plasma or blood can interfere with the resistivity at the electrodes thereby deteriorating their sensitivity for detection of IL-6 at clinically relevant concentrations. [34] So far, the lowest theoretical LOD fo...

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“…The most reported SLIPS use fluorinated materials or coatings for porous substrates and fluorinated lubricant liquids, such as DuPont Krytox oils and 3 m Fluorinert FC‐70 . These fluorinated compounds are expensive so that cheaper alternatives are awaited.…”

Section: Introductionmentioning

confidence: 99%

Fluorine‐Free Slippery Liquid‐Infused Porous Surfaces Prepared Using Hierarchically Porous Aluminum

Inoue

Koyama

Kowalski

et al. 2020

Physica Status Solidi (a)

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Slippery liquid‐infused porous surfaces (SLIPS) have been receiving increased attention. Fluorinated compounds have been used to prepare SLIPS, but because of bioaccumulation and ecological impact of perfluoroalkyl building blocks, the fluorine‐free SLIPS (F‐free SLIPS) system is preferable for practical applications. Herein, SLIPS are prepared from a hierarchically porous aluminum substrate, tetradecylphosphonic acid monolayer coating, and silicone lubricant oil. The several properties of the SLIPS, including durability against lubricant loss, ice adhesion, and corrosion resistance, are compared with those with a fluoroalkyl monolayer coating and fluorinated lubricant oil. The findings demonstrate that the F‐free SLIPS show higher durability against the removal of lubricant in air and also in water. Both fluorinated SLIPS (F‐SLIPS) and F‐free SLIPS samples exhibit extremely reduced ice adhesion compared with superhydrophobic surfaces obtained using the same hierarchically porous aluminum substrate with fluorinated or fluorine‐free monolayer coating. The SLIPS samples have very high corrosion resistance in NaCl solution but not in alkaline solution. The solution‐dependent corrosion resistance is discussed in terms of the stability of monolayer coating.

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Liquid-Infused Surfaces: A Review of Theory, Design, and Applications

Cited by 298 publications

References 135 publications

Bidirectional motion of droplets on gradient liquid infused surfaces

Bidirectional motion of droplets on gradient liquid infused surfaces

Antibody Micropatterned Lubricant‐Infused Biosensors Enable Sub‐Picogram Immunofluorescence Detection of Interleukin 6 in Human Whole Plasma

Fluorine‐Free Slippery Liquid‐Infused Porous Surfaces Prepared Using Hierarchically Porous Aluminum

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