Liquid filled nanoparticles as a drug delivery tool for protein therapeutics

Venkatesan, Natarajan; Yoshimitsu, Jun-Ichiro; Ito, Yoshiaki; Shibata, Nobuhito; Takada, Kanji

doi:10.1016/j.biomaterials.2005.05.012

Cited by 173 publications

(83 citation statements)

References 51 publications

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“…Moreover, poly citric acid is a highly biocompatible polymer. 32,33 Results of infrared, 1 H NMR, and 13 C NMR confirmed conjugation of paclitaxel to the carboxyl functional groups of the poly citric acid branches on the surface of MWNTs via a cleavable ester bond.…”

Section: Discussionmentioning

confidence: 99%

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Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Sobhani¹,

Dinarvand²,

Atyabi³

et al. 2011

IJN

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Potential applications of carbon nanotubes have attracted many researchers in the field of drug delivery systems. In this study, multiwalled carbon nanotubes (MWNTs) were first functionalized using hyperbranched poly citric acid (PCA) to improve their hydrophilicity and functionality. Then, paclitaxel (PTX), a potent anticancer agent, was conjugated to the carboxyl functional groups of poly citric acid via a cleavable ester bond to obtain a MWNT- g -PCA-PTX conjugate. Drug content of the conjugate was about 38% (w/w). The particle size of MWNT- g -PCA and MWNT- g -PCA-PTX was approximately 125 and 200 nm, respectively. Atomic force microscopy and transmission electron microscopy images showed a curved shape for MWNT- g -PCA and MWNT- g -PCA-PTX, which was in contrast with the straight or linear conformation expected from carbon nanotubes. It seems that the high hydrophilicity of poly citric acid and high hydrophobicity of MWNTs led to conformational changes from a linear state to a curved state. Paclitaxel can be released from the MWNT- g -PCA-PTX conjugates faster at pH 6.8 and 5.0 than at pH 7.4, which was suitable for the release of the drug in tumor tissues and tumor cells. In vitro cytotoxicity studies were evaluated in the A549 and SKOV3 cell lines. MWNT- g -PCA had an insignificant cytotoxic effect on both cell lines. MWNT- g -PCA-PTX had more of a cytotoxic effect than the free drug over a shorter incubation time (eg, 24 hours versus 48 hours), which suggests improved cell penetration of MWNT- g -PCA-PTX. Therefore, paclitaxel conjugated to MWNT- g -PCA is promising for cancer therapeutics.

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Section: Discussionmentioning

confidence: 99%

“…The CNT-g-PCA-PTX conjugate was characterized using infrared, 1 H nuclear magnetic resonance (NMR), 13 C NMR, 13 C NMR spectra were recorded on the same instrument using the solvent carbon signal as a reference. Differential scanning calorimetry was used to determine the thermal behavior of the conjugated nanotubes.…”

Section: Characterization Techniquesmentioning

confidence: 99%

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Sobhani¹,

Dinarvand²,

Atyabi³

et al. 2011

IJN

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“…Synthesis of functional and novel carbonaceous materials is a very interesting topic due to its variety of applications such as adsorbents, storage and production of electrodes, energy, nanocomposites, hydrogen storage, catalyst supports [1][2][3][4] drug delivery [5,6], filter materials [7] etc. Black solid residue contains mostly carbon microspheres (CMSs).…”

Section: Aims and Backgroundmentioning

confidence: 99%

Structural properties of carbon microspheres obtained by hydrothermal treatment of fructose

Krstić¹,

Kaluđerović²,

Dodevski³

et al. 2015

Zas Mat

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“…Venkatesan et al [40,41] incorporated erythropoietin (EPO) into a CNT matrix, which was measured out by weight. Intra-jejunal administration of this EPO (100U/kg)-CNTlabrasol solid dispersion increased the bioavailability of EPO.…”

Section: Dispersibilitymentioning

confidence: 99%

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

Földvári

2010

KEM

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Many recently designed drug delivery systems have been constructed from nano-sized components that serve as the carrier or targeting ligand for a therapeutic agent. Even though these materials have been regarded previously as inert or non-active components of dosage forms, they are now recognized as sometimes being even more important than the drug itself. Hence, it is becoming increasingly imperative that the pharmaceutically relevant properties, including identity, physicochemical characteristics, purity, solubility and toxicity, of these functional nano-excipients be fully characterized. Carbon nanotubes (CNTs) are novel nanomaterials made of carbon atoms that have wide application potential in many areas of nanomedicine. However, because of their significant potential, CNTs, as building blocks for nanomedicines, need to be characterized more fully. Studies to date indicate that both physical and chemical properties of CNTs play an important role in their interactions with cells. Therefore, a full understanding of the physical properties of CNTs, such as identity, chirality, particle size, aspect ratio, morphology and dispersion state, as well as chemical properties such as purity, defect sites and types and functional groups, will be essential to develop a full characterization panel of these versatile nanomaterials.

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Liquid filled nanoparticles as a drug delivery tool for protein therapeutics

Cited by 173 publications

References 51 publications

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Structural properties of carbon microspheres obtained by hydrothermal treatment of fructose

Formulating Nanomedicines: Focus on Carbon Nanotubes as Novel Nanoexcipients

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