Liquid crystals based sensing platform-technological aspects

Hussain, Zakir; Qazi, Farah; Ahmed, Mehreen; Usman, Adil; Riaz, Asim; Abbasi, Amna Didar

doi:10.1016/j.bios.2016.04.069

Cited by 69 publications

(29 citation statements)

References 81 publications

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“…Recently, liquid crystals (LCs) have been explored for the construction of electrochemical biosensors . LCs are anisotropic materials with liquid‐like flow properties as well as solid‐like optical properties . Our research group has pioneered the development of label‐free electrochemical immunosensors based on electroactive LC molecules , mainly due to their redox properties and good film‐forming ability on the electrode surface.…”

Section: Introductionmentioning

confidence: 99%

Direct Electrochemical Nano‐immunosensor for Microcystin‐LR in Seawater

et al. 2018

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Microcystins are potent hepatotoxins produced by cyanobacteria, which proliferate in wastewaters with high nutrient content. Due to their high toxicity and potential risk to human health, even at low concentrations, the development of a sensitive and rapid method for the monitoring of microcystin‐LR (MC‐LR) in water samples is of great importance. In this context, a new direct electrochemical nano‐immunosensor for MC‐LR detection using the liquid crystal (E)‐1‐decyl‐4‐[(4‐decyloxyphenyl)diazenyl]pyridinium bromide (Br‐Py) as a redox probe and gold nanoparticles stabilized in bovine serum albumin (AuNP‐BSA) is described herein. The microcystin‐LR antibody (anti‐MC‐LR) was covalently immobilized using N‐(3‐dimethylaminopropyl)‐N‐ethylcarbodiimide hydrochloride (EDC) and N‐hydroxysuccinimide (NHS) on an AuNP‐BSA/BrPy film. The proposed sensor response is based on the inhibition of the Br‐Py electrochemical signal after the specific interaction of MC‐LR with immobilized anti‐MC‐LR on the electrode surface. The electrochemical behavior of the immunosensor was studied by square‐wave voltammetry (SWV) and electrochemical impedance spectroscopy (EIS). Under optimized conditions, using SWV and an incubation time of 15 min, the immunosensor exhibits a linear response to MC‐LR concentrations of 0.05 to 500.0 ng mL−1 with a detection limit of 0.05 ng mL−1. The anti‐MC‐LR/AuNP‐BSA/Br‐Py/GCE was successfully applied in the determination of MC‐LR in spiked seawater samples.

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Section: Introductionmentioning

confidence: 99%

Direct Electrochemical Nano‐immunosensor for Microcystin‐LR in Seawater

et al. 2018

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“…Liquid crystalline phases with different architectures are formed when the amphiphilic concentration in the water exceeds CAC, and this compound self-organizes in a spatially regular manner. The self-organized system depends on a delicate balance between intermolecular forces to promote the structure of LC, and even a small alteration can disrupt the ordered structures of LC [ 48 ]. Amphiphilic self-organization in aqueous or non-aqueous medium also depends on the temperature and the degree of hydrophobic chain introduction [ 49 , 50 , 51 ].…”

Section: Lyotropic Liquid Crystals-based Emulsionmentioning

confidence: 99%

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

et al. 2017

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The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC—drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.

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“…The changes in temperature as well as changes in topography and chemical structure will affect the short-range interaction and long-range orientation sequences of LCs, resulting in orientation transitions. Therefore, LCs can be used as materials that respond to the presence of foreign species or the occurrence of binding events in their vicinity [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Application and Technique of Liquid Crystal-Based Biosensors

Luan

Luo

2020

Micromachines

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Liquid crystal biosensors are based on changes in the orientation of liquid crystal molecules induced by specific bonding events of biomolecules. These biosensors are expected to serve as a promising system to detect biomolecules, biomolecular activity, and even small chemical molecules because they are inexpensive, sensitive, simple, effective, and portable. Herein, we introduce the principle and fabrication of liquid crystal biosensors and review the research progress in signal-amplified technology for liquid crystal sensing and its application in the detection of viruses, bacteria, proteins, nucleic acids, and small chemical molecules. In addition, the current theoretical and practical issues related to liquid crystal biosensors were investigated.

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Liquid crystals based sensing platform-technological aspects

Cited by 69 publications

References 81 publications

Direct Electrochemical Nano‐immunosensor for Microcystin‐LR in Seawater

Direct Electrochemical Nano‐immunosensor for Microcystin‐LR in Seawater

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

Application and Technique of Liquid Crystal-Based Biosensors

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