Liquid crystalline poly(propylene imine) dendrimer-based iron oxide nanoparticles

Abstract

Poly(propylene imine) dendromesogens (generations from 1 to 4) have been utilized for the synthesis and stabilization of ferrimagnetic Fe2O3 nanoparticles.

Advances in functionalization and conjugation mechanisms of dendrimers with iron oxide magnetic nanoparticles

“…2 IOMNPs core-shell amino nanocomposite with P (4-MS-co-DVB-co-GMA) and propagation of PAMAM dendrimer on the surface. 23 MNPs, including poly(amidoamine) (PAMAM), 62,63 poly( propylene imine) (PPI), 5,64 and other types of dendrimers as coatings [65][66][67] The choice of dendrimer depends on the size and shape of the MNP, as well as the desired application. The generation of the dendrimer also plays a crucial role in encapsulation efficiency and stability.…”

“…One example of MNPs encapsulated in dendrimers is the encapsulation of MNPs within a poly( propylene imine) (PPI) dendrimer. 5,68 The encapsulation was achieved through a three-step synthesis process conducted in a dry THF solution under an argon atmosphere. In the first step, iron hydroxide was formed within the dendrimer matrix as an intermediate product.…”

“…PPI dendrimers, a type of cationic dendrimers, have proven to be valuable in the functionalization of MNPs, offering enhanced stability and improved effectiveness across a range of applications. Synthetic approaches of MNPs with PPI quite differ from encapsulation 5,64,68 to covalent conjugation with the aid of functionalized MNPs with silanes 104 or other anchoring groups. 34 The synthesis of magnetic NPs involved the preparation of maghemite ferrofluid through a controlled alkaline coprecipitation method of Fe(II) and Fe(III) ions, followed by oxidation to maghemite (γ-Fe 2 O 3 ).…”

“…Furthermore, dendrimers can improve the stability of MNPs in physiological conditions, preventing aggregation and enhancing solubility, which are critical for biomedical applications such as in vivo imaging and targeted drug delivery. [4][5][6][7] Understanding the mechanism of conjugation and functionalization of MNPs with dendrimers is of paramount importance. By working on the underlying processes and interactions, researchers can optimize the loading of functional groups, enhance dispersibility in solvents, and facilitate the attachment of ligands, scavengers, catalysts, and reagents.…”

“…Furthermore, dendrimers can improve the stability of MNPs in physiological conditions, preventing aggregation and enhancing solubility, which are critical for biomedical applications such as in vivo imaging and targeted drug delivery. 4–7…”