Liquid crystalline nanoparticles for drug delivery: The role of gradient and block copolymers on the morphology, internal organisation and release profile

Perinelli, Diego Romano; Foryś, Aleksander; Bonacucina, Giulia; Trzebicka, Barbara; Pispas, Stergios; Demetzos, Costas

doi:10.1016/j.ejpb.2020.08.008

Cited by 23 publications

(27 citation statements)

References 86 publications

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“…The drug-release studies were conducted using the dialysis method in the dark, [ 15 , 23 , 31 , 60 , 61 ] based on a previous study [ 28 ]. 0.5 mL of the aqueous solution samples were placed into a dialysis sack, with a molecular weight cutoff at 10,000.…”

Section: Methodsmentioning

confidence: 99%

“…To form stable LCNPs, aqueous dispersions of lipids require the addition of stabilizers, such as surfactants or amphiphilic block copolymers, which are one of the main class of polymeric stabilizers for these nanosystems [ 9 , 26 ]. It has been proven that the copolymers play a key role on the resulting formulation and determining the mesophases of final structures, while it also prevents unfavorable interactions between nanoparticles, such as aggregation [ 27 , 28 ]. In this case, hydrophilic block should be on the outer rim in the role of a hydrophilic corona, while the hydrophobic blocks should be anchored inside the lipid bilayer, forming hydrophobic interactions with the hydrophobic lipid tails.…”

Section: Introductionmentioning

confidence: 99%

“…One of the most popular lipids is glyceryl monooleate (GMO) [ 2 , 8 , 26 , 35 ] which is a polar, unsaturated monoglyceride. It can self-assemble into different mesophases, depending on water concentration and temperature [ 8 , 27 , 28 ]. Glyceryl monooleate is a nontoxic, biodegradable and biocompatible material, through it is commonly used for the preparation of liquid crystalline nanoparticles for drug delivery systems [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, amphiphilic block copolymers were synthesized consisting of hydrophilic poly(ethylene oxide) and different hydrophobic blocks of poly(lactic acid) and poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PMEC). We also compared its stabilizing ability with previously studied poly(ethylene oxide)- b -poly(ε-caprolactone) (PEO- b -PCL) block copolymers [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studied LCNPs served as nanocarriers of resveratrol, a model hydrophobic drug that is a well-studied biologically active compound and exhibits various pharmacological properties. Among the many, it can be distinguished as anti-oxidative, anti-inflammatory, neuro-protective, anti-aging and anticancer drug [ 28 , 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery

et al. 2021

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The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use amphiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octadecenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, depending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/lipid nanostructures.

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