Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

Rakotoarisoa, Miora; Angelov, Borislav; Drechsler, Markus; Nicolas, Valérie; Bizien, Thomas; Gorshkova, Yu. E.; Deng, Yuru; Angelova, Angelina

doi:10.1016/j.smaim.2022.03.001

Cited by 35 publications

(24 citation statements)

References 106 publications

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“…It is worth noting that, even though Pluronic surfactants are the most common stabilizing agents reported in the literature for the preparation of cubosomes, other agents have also been reported, such as D-α-tocopheryl poly(ethylene glycol)1000 succinate [63] and Poloxamer 407 [64].…”

Section: Principal Constituentsmentioning

confidence: 99%

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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The impact of nanotechnology on the exponential growth of several research areas, particularly nanomedicine, is undeniable. The ability to deliver active molecules to the desired site could significantly improve the efficiency of medical treatments. One of the nanocarriers developed which has drawn researchers’ attention are cubosomes, which are nanosized dispersions of lipid bicontinuous cubic phases in water, consisting of a lipidic interior and aqueous domains folded in a cubic lattice. They stand out due to their ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, their tortuous internal configuration that provides a sustained release, and the capacity to protect and safely deliver molecules. Several approaches can be taken to prepare this structure, as well as different lipids like monoolein or phytantriol. This review paper describes the different methods to prepare nanocarriers. As it is known, the physicochemical properties of nanocarriers are very important, as they influence their pharmacokinetics and their ability to incorporate and deliver active molecules. Therefore, an extensive characterization is essential to obtain the desired effect. As a result, we have extensively described the most common techniques to characterize cubosomes, particularly nanocarriers. The exceptional properties of the cubosomes make them suitable to be used in several applications in the biomedical field, from cancer therapeutics to imaging, which will be described. Taking in consideration the outstanding properties of cubosomes, their application in several research fields is envisaged.

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Section: Principal Constituentsmentioning

confidence: 99%

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

et al. 2022

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“…It binds to the receptor and activates the MAPK, PI3K and PLC-γ signaling pathways, which are implicated in neuroprotective and neuroregenerative effects [158]. The BDNF mechanism is used as an emerging targeted strategy in neurorepair [29,158,159]. Figure 7 shows the BDNF-TrkB signaling involved in synaptic transmission.…”

Section: Bdnf Delivery By Nanocarriers and Nanoscale Materials In Neu...mentioning

confidence: 99%

“…Multicomponent amphiphilic systems with liquid crystalline selfassembled inner structural organization can serve for the encapsulation of hydrophobic or hydrophilic drugs and natural antiviral compounds for targeting various disease mechanisms as well as pathways favoring recovery from SARS-CoV-2-induced neuronal damage. In examples of multidrug (ω-3 PUFAs, curcumin, and monoglyceride) loading in nanoparticles, curcumin has been considered a drug with antiviral, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, neuroprotective and cardioprotective properties [159]. Monoglycerides have been indicated to have equal capacity for viral inactivation at 5 to 10 times lower concentrations than their corresponding fatty acids.…”

Section: Nanoscale Assemblies Of Bioactive Lipids Offering Therapeuti...mentioning

confidence: 99%

“…Monoglycerides have been indicated to have equal capacity for viral inactivation at 5 to 10 times lower concentrations than their corresponding fatty acids. ω-3 PUFAs are adjunctive therapeutics of strong interest for preventive nanomedicine development [159,185]. Recent experimental data have shown that curcumin-loaded lipid nanoparticles may promote BDNF expression and that the ω-3 PUFA content of the nanoparticles may be beneficial for enhancing BDNF activity [159,186].…”

Section: Nanoscale Assemblies Of Bioactive Lipids Offering Therapeuti...mentioning

confidence: 99%

“…ω-3 PUFAs are adjunctive therapeutics of strong interest for preventive nanomedicine development [159,185]. Recent experimental data have shown that curcumin-loaded lipid nanoparticles may promote BDNF expression and that the ω-3 PUFA content of the nanoparticles may be beneficial for enhancing BDNF activity [159,186].…”

Section: Nanoscale Assemblies Of Bioactive Lipids Offering Therapeuti...mentioning

confidence: 99%

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Self-Assembled Nanoscale Materials for Neuronal Regeneration: A Focus on BDNF Protein and Nucleic Acid Biotherapeutic Delivery

Rakotoarisoa

Angelov

et al. 2022

Nanomaterials

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Enabling challenging applications of nanomedicine and precision medicine in the treatment of neurodegenerative disorders requires deeper investigations of nanocarrier-mediated biomolecular delivery for neuronal targeting and recovery. The successful use of macromolecular biotherapeutics (recombinant growth factors, antibodies, enzymes, synthetic peptides, cell-penetrating peptide–drug conjugates, and RNAi sequences) in clinical developments for neuronal regeneration should benefit from the recent strategies for enhancement of their bioavailability. We highlight the advances in the development of nanoscale materials for drug delivery in neurodegenerative disorders. The emphasis is placed on nanoformulations for the delivery of brain-derived neurotrophic factor (BDNF) using different types of lipidic nanocarriers (liposomes, liquid crystalline or solid lipid nanoparticles) and polymer-based scaffolds, nanofibers and hydrogels. Self-assembled soft-matter nanoscale materials show favorable neuroprotective characteristics, safety, and efficacy profiles in drug delivery to the central and peripheral nervous systems. The advances summarized here indicate that neuroprotective biomolecule-loaded nanoparticles and injectable hydrogels can improve neuronal survival and reduce tissue injury. Certain recently reported neuronal dysfunctions in long-COVID-19 survivors represent early manifestations of neurodegenerative pathologies. Therefore, BDNF delivery systems may also help in prospective studies on recovery from long-term COVID-19 neurological complications and be considered as promising systems for personalized treatment of neuronal dysfunctions and prevention or retarding of neurodegenerative disorders.

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