Liquid-Crystalline Dispersions of Double-Stranded DNA

Yevdokimov, Yu. M.; Skuridin, S. G.; Salyanov, V. I.; Semenov, S.; Kats, E. I.

doi:10.3390/cryst9030162

Cited by 14 publications

(14 citation statements)

References 84 publications

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“…The DNA dispersions have been formed as the result of phase exclusion of these molecules when aqueous-salt solutions of DNA were mixed with aqueous-salt solutions of PEG [19].…”

Section: ≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡mentioning

confidence: 99%

“…The disappearance of the abnormal band amplitude in the CD spectra of CLCDs corresponds to the transition to a structure with a distorted location of the neighboring DNA molecules within the particles. This is known as the "CD melting" of the spatial structure of CLCDs [19].…”

confidence: 99%

“…This behavior yielding to a new LC structure has been termed the "re-entrant" phenomenon. Our motivation for presenting this manuscript is the new results (see details below) which have emanated for the time elapsed after that publication [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disorder of DNA Structure in Quasinematic Layers of “Re-entrant” Twisted Phases

Yevdokimov¹,

Skuridin²,

Semenov³

et al. 2021

Liq. Cryst. and their Appl.

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The CD spectra of double-stranded (ds) DNA dispersion particles with the "re-entrant" cholesteric structures formed in poly(ethyleneglycol)-containing solutions are compared. The high osmotic pressure of the solvent results in the dense packing DNA molecules and alteration of their secondary structure as well as a disorder of molecules in quasinematic layers of dispersion particles. Under these conditions, it is impossible to connect the adjacent ds DNA molecules by specific cross-links (nanobridges).

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“…The DNA dispersions have been formed as the result of phase exclusion of these molecules when aqueous-salt solutions of DNA were mixed with aqueous-salt solutions of PEG [19].…”

confidence: 99%

See 1 more Smart Citation

Disorder of DNA Structure in Quasinematic Layers of “Re-entrant” Twisted Phases

Yevdokimov¹,

Skuridin²,

Semenov³

et al. 2021

Liq. Cryst. and their Appl.

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“… Евдокимов Ю. М., Салянов В. И., Компанец О. Н., Кац Е. И., Скуридин С. Г., 2019 ≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡≡ Введение Известно, что при комнатной темпеpатуpе в водно-солевых растворах могут быть сформированы как жидкокристаллические (ЖК) фазы, так и жидкокристаллические дисперсии (ЖКД) двухцепочечных (дц) молекул ДНК [1]. Пеpеxод от ЖК-фаз к частицам ЖКД, формируемым в результате фазового исключения молекул ДНК из водно-солевых растворов полимеров, приводит к поcтановке вопpоcа о том, каким обpазом упакованы молекулы дц ДНК в частицах дисперсий [2][3][4].…”

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“…1 , достаточно близки. При этом в отличие от частиц дисперсий с «возвратной» холестерической упаковкой, сформированных при осмотическом давлении раствора ПЭГ 11,33 атм.…”

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Optical Properties of the DNA Particles of Cholesteric and «Re-Entrant» Cholesteric Phases

Yevdokimov¹,

Salyanov²,

Kompanets³

et al. 2019

Liq. Cryst. and their Appl.

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Phase exclusion of DNA molecules from polyethylene glycol (PEG) water-salt solutions leads to formation at room temperature of liquid-crystalline dispersions (LCD) with cholesteric and hexagonal packing of DNA molecules, determined by the osmotic pressure of the PEG solution. LCDs with cholesteric DNA packing (CLCD) have an intense negative band in the circular dichroism (CD) spectrum in the absorption region of nitrogen bases. LCD particles with hexagonal packing have no abnormal band. With increase of the solution temperature containing DNA CLCD particles, a decrease in the abnormal band in the CD spectrum is observed. Cooling of the dispersion leads not only to the restoration of the initial abnormal band, but also increases its amplitude. When the heating LCD with hexagonal DNA packing occurs, such band appears, i.e. there is the "hexagonal packing →"re-entrant"cholesteric packing phase transition. Cooling of the "re-entrant" cholesteric phase (C PEG = 240 mg ml-1) is accompanied by further increase in abnormal optical activity, whereas cooling of the dispersion formed at C PEG = 300 mg ml-1 causes decrease of the abnormal band amplitude. Consequently, equilibrium amplitude values of abnormal bands in CD spectra of these dispersion particles are realized as a result of multidirectional processes. When cooled to room temperature, the kinetic curves designating changes in the spatial structure of LCD particles with the "re-entrante" cholesteric packing of DNA molecules have a wave-like character. Comparison of these curves shows that the osmotic pressure increase of the PEG solution is accompanied by the increase of the wave-like character. Thus, the formation of the "re-entrant" cholesteric phases of DNA is determined not only by the osmotic pressure and temperature of PEG solution, but also by the average distance between DNA molecules in dispersion particles with the original hexagonal packing. Key words: liquid-crystalline ds DNA dispersion particles, circular dichroism, abnormal optical activity, cholesteric packing of ds DNA molecules, hexagonal packing of ds DNA molecules, temperature kinetics of formation of ds DNA cholesteric "re-entrant" phase, hexagonal → "re-entrant" phase of ds DNA transition.

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DNA‐Based Dissipative Assembly toward Nanoarchitectonics

Liu

et al. 2022

Adv Funct Materials

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Figure 4. Dissipative DNA assemblies fueled by redox reactions. A) Left panel: The reversible release of a ligand from a DNA sequence fueled by a redox reaction. Right panel: The fluorescence evolution upon the repeated addition of the disulfide-linked DNA modulator. Reproduced with permission. [36] Copyright 2020, Wiley-VCH. B) Top left panel: Schematic illustration of the transient self-assembly of DNA nanotubes activated by disulfide-containing DNA. Top middle panel: The measured DNT formation in the presence of disulfide activators with various lengths at 1 and 24 h. Top right panel: Fluorescence microscopy images of transient DNA nanotubes in the presence of Act_16. Bottom left panel: Schematic illustration of the transient selfassembly of DNA nanotubes inhibited by disulfide-containing DNA. Bottom middle panel: The measured DNA nanotube formation in the presence of disulfide inhibitors with various lengths at 1 and 24 h. Bottom right panel: Fluorescence microscopy images of transient DNA nanotubes in the presence of Inhib_14. Reproduced with permission. [37] Copyright 2020, Wiley-VCH.

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Liquid-Crystalline Dispersions of Double-Stranded DNA

Cited by 14 publications

References 84 publications

Disorder of DNA Structure in Quasinematic Layers of “Re-entrant” Twisted Phases

Disorder of DNA Structure in Quasinematic Layers of “Re-entrant” Twisted Phases

Optical Properties of the DNA Particles of Cholesteric and «Re-Entrant» Cholesteric Phases

DNA‐Based Dissipative Assembly toward Nanoarchitectonics

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