Liquid crystal polymer (LCP)-based neural prosthetic devices

Gwon, Tae Mok; Kim, Chaebin; Shin, Soowon; Park, Jeong Hoan; Kim, Jin Ho; Kim, Sung June

doi:10.1007/s13534-016-0229-z

Cited by 35 publications

(18 citation statements)

References 81 publications

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“…During formation of polymer-based probes, to provide stiff base and ensure compatibility with processing equipment, silicon, or glass wafers are used as a temporary host substrates. Out of many polymers introduced for neural implants, a few gained the most attention due to their inertness, CMOS-compatibility and possibility to be used as both a substrate and encapsulation, including polyimide, Parylene-C, LCP, benzocyclobutene (BCB), and SU-8 (Lin et al, 2002 ; Hassler et al, 2011 ; Gwon et al, 2016 ). They are characterized by chemical inertness, low moisture permeability, low dielectric constant, and can be functionalized with organic agents.…”

Section: Polymer Microelectrodesmentioning

confidence: 99%

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

2017

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Implantable neural interfaces for central nervous system research have been designed with wire, polymer, or micromachining technologies over the past 70 years. Research on biocompatible materials, ideal probe shapes, and insertion methods has resulted in building more and more capable neural interfaces. Although the trend is promising, the long-term reliability of such devices has not yet met the required criteria for chronic human application. The performance of neural interfaces in chronic settings often degrades due to foreign body response to the implant that is initiated by the surgical procedure, and related to the probe structure, and material properties used in fabricating the neural interface. In this review, we identify the key requirements for neural interfaces for intracortical recording, describe the three different types of probes—microwire, micromachined, and polymer-based probes; their materials, fabrication methods, and discuss their characteristics and related challenges.

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Section: Polymer Microelectrodesmentioning

confidence: 99%

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

2017

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“…Polymers are an alternative material class for substrates. Liquid crystal polymer, parylene C, polyimide, silicone rubber and SU 8 and are mechanically more flexible which is supposed to be advantageous with respect to tissue reactions [35,[38][39][40][41][42][43]. Flexible substrates and probes need insertion tools for implantation into the brain or the peripheral nerve.…”

Section: Substrate Materialsmentioning

confidence: 99%

Why Neurotechnologies? About the Purposes, Opportunities and Limitations of Neurotechnologies in Clinical Applications

Stieglitz

2019

Neuroethics

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Neurotechnologies describe a field of science and engineering in which the nervous system is interfaced with technical devices. Fundamental research is conducted to explore functions of the brain, decipher the neural code and get a better understanding of diseases and disorders. Risk benefit assessment has been well established in all medical disciplines to treat patients best possible while minimizing jeopardizing their lives by the interventions. Is this set of assessment rules sufficient when the brain will be interfaced with a technical system and is this assessment enough? How will these new technologies change personality and society? This article will shortly review different stakeholders' opinions and their expectation in the field, assembles information the state-of-the art in medical applications of neurotechnological implants and describes and assesses the fundamental technologies that are used to build up these implants starting with essential requirements of technical materials in contact with living tissue. The different paragraphs guide the reader through the main aspects of neurotechnologies and lay a foundation of knowledge to be able to contribute to the discussion in which cases implants will be beneficial and in which cases we should express serious concerns.

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“…1 Properties of silicon, silica, and polymeric biocompatible materials [36] ------48 Table 2.2 Conditions of current stimulation in the simulation -------------------------66 Table 2.3 Features of electrode site designs for locally tripolar stimulation --------67 Table 3.1 Summarized results of absolute value of e-field distribution ------------106 Table 3. Table 3.…”

Section: List Of Tablesmentioning

confidence: 99%

“…Properties of silicon, silica, and polymeric biocompatible materials[36] Biocompatibility of LCP has been evaluated. The requirements and general testing procedures described in the International Organization for Standardization (ISO) 10993 that provides necessary guidelines for the materials to be used in medical devices have been met in some grades of Vectra LCP.…”

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confidence: 99%

A Polymer Cochlear Electrode Array: Atraumatic Deep Insertion, Tripolar Stimulation, and Long-Term Reliability

Gwon¹

2018

Springer Theses

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Biocompatible polymers have gained widespread interest in implantable biomedical applications due to their flexibility and compatibility with micro-fabrication processes. Liquid crystal polymer (LCP) is an inert, highly water-resistant, and thermoplastic polymer suitable for the encapsulation of electronic components and as a base material for fabricating neural interfaces. Feasibility of monolithic integration of neural interface and electronics packaging and its extremely low water absorption rate (< 0.04 %) enable LCP-based implantable devices that have salient benefits in terms of performance and reliability. In this dissertation, new design of LCP-based neural interfaces, especially cochlear electrode arrays, are proposed and evaluated within their purposes on fabrication process, functionality, and reliability. The following issues of LCP-based cochlear electrode arrays are studied: atraumatic deep insertion, tripolar stimulation, and long-term reliability. Flexible LCP-based cochlear electrode array has been studied, but, there is no electrode design for an atraumatic insertion in terms of structural approach. An atraumatic cochlear electrode array has become indispensable to high-performance cochlear implants such as electric acoustic stimulation foretells the development of cochlear electrode array for an atraumatic deep insertion, advanced stimulation, and long-term clinical implant.

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Liquid crystal polymer (LCP)-based neural prosthetic devices

Cited by 35 publications

References 81 publications

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics

Why Neurotechnologies? About the Purposes, Opportunities and Limitations of Neurotechnologies in Clinical Applications

A Polymer Cochlear Electrode Array: Atraumatic Deep Insertion, Tripolar Stimulation, and Long-Term Reliability

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