2018
DOI: 10.1039/c7sm01949a
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Liquid crystal elastomer foams with elastic properties specifically engineered as biodegradable brain tissue scaffolds

Abstract: Tissue regeneration requires 3-dimensional (3D) smart materials as scaffolds to promote transport of nutrients. To mimic mechanical properties of extracellular matrices, biocompatible polymers have been widely studied and a diverse range of 3D scaffolds have been produced. We propose the use of responsive polymeric materials to create dynamic substrates for cell culture, which goes beyond designing only a physical static 3D scaffold. Here, we demonstrated that lactone- and lactide-based star block-copolymers (… Show more

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Cited by 61 publications
(77 citation statements)
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“…After solvent removal and crosslinking completion, template removal results in 3D scaffolds showing a complementary morphology with respect to the templates. Notably, to the best of our knowledge, these last 3D samples present polydomain structures because no alignment procedures are applied during the crosslinking, and the shape‐changing behaviour of these samples has not been yet investigated …”
Section: Preparation Methods and Smart Properties Of Lcesmentioning
confidence: 99%
See 3 more Smart Citations
“…After solvent removal and crosslinking completion, template removal results in 3D scaffolds showing a complementary morphology with respect to the templates. Notably, to the best of our knowledge, these last 3D samples present polydomain structures because no alignment procedures are applied during the crosslinking, and the shape‐changing behaviour of these samples has not been yet investigated …”
Section: Preparation Methods and Smart Properties Of Lcesmentioning
confidence: 99%
“…d) Schematization of the salt‐template etching process to prepare LCE foams to be used as scaffolds from brain cell, and confocal image ( x , y ‐ and x , z ‐plane) obtained in LCE foams (green) after 30 days (right) showing cell proliferation; Adapted from ref. with permission of The Royal Society of Chemistry, Copyright (2018). e) Orientation maps obtained by imageJ of C2C12 and hDF seeded on a LCE or on a Petri dish (20× lens magnification).…”
Section: Liquid Crystalline Polymers For Cell Culture and Tissue Engimentioning
confidence: 99%
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“…The process, allows for control of pore size, density, and morphology 17,20. Highly interconnected pores (>85%21) provide suitable mass transport where cells have constant access to nutrients, gases, and waste management, reducing cell death and increasing viability,35 avoiding mass transfer restrictions,36 where diffusion of nutrients, and oxygen are promoted by the scaffold structure. The presence of LC moieties promote cell attachment and proliferation, as well as orientation and anisotropic cell growth,19 allowing the creation of neural networks in organized patterns to serve specific functions and that mimicking endogenous systems.…”
mentioning
confidence: 99%