Liquid crystal-based detection of thrombin coupled to interactions between a polyelectrolyte and a phospholipid monolayer

Jang, Chang‐Hyun

doi:10.1016/j.ab.2014.03.018

Cited by 27 publications

(13 citation statements)

References 25 publications

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“…The NPs could be used for biosening by either deposition on the substrate before NLC interaction or by insertion into the NLC system or both for signal enhancement. Correspondingly, in one type of biosensor, NPs are deposited on the substrate along with specific biomolecules before the filling of the NLC in the sample cell, and in another type, the mixture of the NPs and the biomolecules is inserted into the NLC [ 53 , 70 , 95 , 96 ].…”

Section: Resultsmentioning

confidence: 99%

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Choudhary

George

2018

Biosensors

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The established role of nematic liquid crystals (NLCs) in the recent rapid development of displays has motivated researchers to modulate the electro-optical properties of LCs. Furthermore, adding nanomaterials into NLCs has led to enhancements of the properties of NLCs, like reduced threshold of the operating voltage, variation in pretilt angle, reduced switching time, etc. These enhanced properties, due to interfacial dynamics, are enabling wider applications of NLCs and nanomaterials. The recent literature of nanomaterial-doped NLCs is rich with various kinds of nanomaterials in a variety of NLCs. The light has been focused on the most widely used and studied gold nanoparticles in NLCs. The intrinsic inherent property of easy excitation of surface plasmons polaritons (SPP) is the mediating interaction of NLC electric dipoles and the polarization of charges in the GNP surface. The concepts and methods for the application of metal nanomaterials as dopants in NLCs are discussed for future applications, especially biosensors. The biosensing application of NLCs alone has already been proven in the literature. However, it is always desirable to further enhance the detection efficiency and selectivity, which have been achieved by the conjugation of GNPs and nickel nanoparticles with NLCs and their compatibility with biological materials. This aspect of future application of nanoparticles and NLC makes the point more selective to be included in the present manuscript.

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Section: Resultsmentioning

confidence: 99%

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Choudhary

George

2018

Biosensors

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“…This result is consistent with previous research, which demonstrated that the orientational changes of LCs correspond to the formation of the phospholipid monolayer at aqueous-LC interfaces. 16 In this study, phospholipid solution at a concentration of 0.5 mM was utilized as a detection substrate. After oxidation by Fenton reaction, oxidized PAPC which remain at the interface prevent self-assembling, inducing orientational changes of LCs from the homeotropic to planar transition.…”

Section: Lc-based Sensor For Imaging Oxidation Effects Of the Fenton mentioning

confidence: 99%

“…[15][16][17] The biological activity involved in combining phospholipids was demonstrated to trigger orientational transition of LCs that can be readily visualized under crossed polarizers. [18][19][20] This coupling provides the foundation for transduction and amplification of biological events that occur at these interfaces.…”

Section: Introductionmentioning

confidence: 99%

Anchoring Transitions of Liquid Crystals for Optical Amplification of Phospholipid Oxidation Inhibition by Ascorbic Acid

Jang

2015

ANAL. SCI.

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“…The orientational properties of LC transduce and amplify a molecular event at the aqueous/LC interface into optical signals under polarising optical microscopy (POM); then these signals are visible to the naked eye. [10][11][12][13] These systems offer an effective, simple and real-time tool for monitoring biological interactions involving lipids, [14] proteins, [15] bacteria, [16] etc. However, the fabrication of LC biosensors is challenging because the LC sensing interface coupled to targeted biological interactions is difficult to control due to the surface geometry and elastic properties of LCs.…”

Section: Introductionmentioning

confidence: 99%

Selective and direct detection of free amino acid using the optical birefringent patterns of confined nematic liquid crystals

Wei

Jang

2016

Liquid Crystals

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Detection of amino acid (AA) is an essential step to understand various biological processes. In this study, we used innovative optical birefringent patterns of nematic liquid crystals (LCs) for the detection of several AAs. We attempted to use capillary-confined nematic LCs as sensor for AA analysis because their three-dimensional micro-scale architecture of LCs allowed better performance than that of mainly reported LC thin film sensors owing to the effect on the formation and dynamics of point defect. The sensing system was built by disrupting the alignment of a nematic LC, 4-cyano-4′-pentylbiphenyl (5CB), using the dopant of dodecyl aldehyde. Detection principle is based on the chemical analytical method of aldehyde titration for AAs, wherein the reaction between AAs and aldehyde group generates Schiff bases that could alter the configuration of nematic LCs at the aqueous/LC interface. The patterns generated in the reaction are captured by polarising optical microscopy (POM) and are visible to the naked eye. The functionalised LCs detected glycine at concentrations as low as 1 pM. There was a surprising result that it can selectively detect D-AAs against their L-isomers, however, further efforts are required to explain the mechanism.ARTICLE HISTORY

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Liquid crystal-based detection of thrombin coupled to interactions between a polyelectrolyte and a phospholipid monolayer

Cited by 27 publications

References 25 publications

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Anchoring Transitions of Liquid Crystals for Optical Amplification of Phospholipid Oxidation Inhibition by Ascorbic Acid

Selective and direct detection of free amino acid using the optical birefringent patterns of confined nematic liquid crystals

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