Liquid‐core waveguide in CE

Abstract

Liquid-core waveguide (LCW) brings about several advantages in CE. This review discusses some aspects of fundamental and practical importance involved in this method. Sensitivity in absorption and fluorescence detection is in general improved by more than one order of magnitude over usual crossbeam detection arrangements; the improvements come from the long light path in absorption detection and low light scattering in fluorescence detection. Versatile instrumental arrangements are another advantage of LCW in CE, leading to several detection schemes, some of which provide information that is not gained by usual capillary-end crossbeam detection, e.g. whole-capillary imaging, simultaneous monitoring of multicapillary separation, and kinetic evaluation. The high potential and perspectives of LCW in CE are discussed based on the state-of-the-art developments.

Dynamic Mass Transfer of Hemoglobin at the Aqueous/Ionic-Liquid Interface Monitored with Liquid Core Optical Waveguide

“…The key for the successful construction of a liquidcore optical waveguide system is the formation of TIR at the liquid/liquid interfaces, as described elsewhere. 28,29 In the present study, imidazolium IL BBmimPF 6 and BmimPF 6 are used as the liquid core of the optical waveguide system. (The fundamental properties are given in the Supporting Information, Table S1.)…”

“…The key for the successful construction of a liquid-core optical waveguide system is the formation of TIR at the liquid/liquid interfaces, as described elsewhere. , …”

“…Liquid core waveguide has been demonstrated to be effective for enhancing the sensitivity for spectrophotometric detection − by extending optical path length via the formation of total internal reflection (TIR) at the interfaces. It offers a powerful tool for real-time monitoring of the local reactions at the core-cladding interface , and the dynamic transferring procedures across the interface. − …”

Noise analysis and measurement of integrator-based sensor interface circuits for fluorescence detection in lab-on-a-chip applications

“…Others illuminate the microfluidics orthogonal to the detector, reducing the LCE E to 0.3-5% [13,16,18,48,49,50] with either the use of waveguides or using focused excitation. Chediak et al…”

Rapid Capillary Zone Electrophoresis Along Short Separation Pathways and Its Use in Some Hyphenated Systems: A Critical Review

“…A classical waveguiding fiber is attached to the detection end of the capillary and led to a photomultiplier, or a photomultiplier is placed directly at the capillary detection end, possibly through a simple absorption filter. The fluorescence is excited by light-emitting diodes, LEDs; for details, see the reviews in refs and and the references therein.…”