2016
DOI: 10.1016/j.jpedsurg.2016.02.053
|View full text |Cite
|
Sign up to set email alerts
|

Liquid chromatography–mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 9 publications
(4 citation statements)
references
References 15 publications
0
4
0
Order By: Relevance
“…It was obvious that the function is complicated and difficult for clinical application; therefore, a composite score system was then established for easy prediction (Table 3). Of note, because the IBA value varied depending on the instruments or reagents used, [12,21] we standardized the serum bile acid value using the multiple of the median (MoM) value. Since we had tested the IBA concentrations of normal control, we could calculate the MoM, which is defined as the ratio of the actual measured value over the normal median value of IBA (Supplemental Table S1).…”
Section: Derivation Cohortmentioning
confidence: 99%
“…It was obvious that the function is complicated and difficult for clinical application; therefore, a composite score system was then established for easy prediction (Table 3). Of note, because the IBA value varied depending on the instruments or reagents used, [12,21] we standardized the serum bile acid value using the multiple of the median (MoM) value. Since we had tested the IBA concentrations of normal control, we could calculate the MoM, which is defined as the ratio of the actual measured value over the normal median value of IBA (Supplemental Table S1).…”
Section: Derivation Cohortmentioning
confidence: 99%
“…Remarkably and unexpectedly, our data suggests that the microbiome before KP may be unique to BA and impact the success of the procedure, in particular, early features of bile flow. Although cholestatic liver diseases in infancy often have similar amounts of fecal bile acids present (33), we found a possibly unique microbiome associated with infants with BA. This suggests that other factors in addition to bile flow may be affecting the infant microbiome in BA.…”
Section: Discussionmentioning
confidence: 66%
“…The metabolic and immune effects of secondary bile acids in liver disease require further investigation. In BA, serum bile acid profiles have been used as a diagnostic tool to discriminate between BA and non-BA infantile cholestasis, but increasingly studies have described a reduction in total and primary faecal bile acids (71,72). Molecular analysis has demonstrated a reduction in 7a-dehydroxylating bacteria, Lachnospiraceae, Blautia, and Clostridium XIVa in BA, although a concomitant reduction in secondary bile acids has yet to be described.…”
Section: Gut Microbiome-bile Acid Interactionmentioning
confidence: 99%