Liquid chromatography—mass spectrometry in forensic toxicology

Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry

“…Some overlaps between transitions of the analytes are observed (see Table 1) between BZE and NCO and have already been described by Van Bocxlaer et al in 2000 [22]. However, in contrast to their work, the chromatographic system described here separates the analytes and eliminates the problem.…”

Analysis of hydroxylated polybrominated diphenyl ethers in plant samples using ultra performance liquid chromatography-mass spectrometry

“…OH-PBDEs were the compounds with high polarity and high molecular mass. ESI has the potential to ionize a wide variety of analytes including compounds with high polarity and/or high molecular mass; while APCI is limited to moderate polarity and moderate molecular mass compounds [21]. Previous research has found that ES operated in negative mode (ES-) can produce a higher signal for the OH-PBDEs than APCI [17].…”

Determination of Illicit Drugs in Urine and Plasma by Micro-SPE Followed by HPLC–MS/MS

“…Urine drug testing is the most widely used for monitoring drug abuse in workplaces and undergoes to strict regulations [18]. The analysis of drugs of abuse in biological samples has been reviewed by various authors [19][20][21][22]: gas chromatography (GC) and specially GC coupled with mass spectrometry (MS) are the most widely used technique for confirmatory of positive screening tests because they provide high level of selectivity and sensitivity [9,[23][24][25][26]; liquid chromatography (LC)-MS is more versatile, does not require derivatization of target compounds and sample pretreatment is usually simpler [27,28]; more recently LC-MS and LC-MS 2 are becoming more commonly used than GC-MS and GC-MS 2 in this field [29,30].…”