Liquid chromatography/electrospray ionization tandem mass spectrometry study of repaglinide and its forced degradation products

Abstract

The forced degradation of RP carried out as per ICH guidelines results in the formation of six degradation products which have been characterized using LC/MS/MS in combination with accurate mass measurements.

Identification, characterisation and in silico ADMET prediction of ozenoxacin and its degradation products using high‐performance liquid chromatography‐photodiode array and liquid chromatography‐quadrupole time‐of‐flight‐tandem mass spectrometry

“…The mass fragmentation pathway for the OXC and its corresponding DPs was established using the ESI technique in positive mode. During the sample run, the QTOF parameters, including capillary voltage, fragmentor voltage, skimmer voltage, drying gas flow, dry gas temperature, collision gas, drying gas and nebuliser gas, were optimised to enhance the intensity of the molecular ion peaks and their fragments 24 …”

Stress degradation study of Etoricoxib, isolation, and characterization of major degradation impurity by preparative high‐performance liquid chromatography, liquid chromatography‐mass spectrometry, and nuclear magnetic resonance: Validation of ultra‐performance liquid chromatography method

“…1 H-NMR, 13 C NMR, and 2D NMR data were generated on Bruker (400 MHz) instrument under the method parameters relaxation delay (D1) = 1 s, acquisition (AQ) = 4.19 s, pulse prog = zg30, number of scans (NS) = 64 s, dwell time (DT) = 64 s, and no. of data points (TD) = 64K, with DMSO-d6 solvent.…”

“…The main aim of the present study was to establish the nature of degradation impurities that involved enrichment, isolation, and characterization of degradation impurities, and the development and validation of suitable stability-indicating analytical method. Liquid chromatography-mass spectrometry (LC-MS), high-resolution mass spectrometry (HR-MS) [9][10][11][12][13][14], and two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy [15][16][17][18][19][20][21][22] techniques have been extensively used as powerful technologies in identifying and characterizing DPs.…”

Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

“…It is worth mentioning that none of them was documented in the pharmacopoeial monograph of repaglinide. In addition, one report from the literature [38] described the stress degradation of repaglinide and reported six degradation products (DPs 8-13). Four DPs (8)(9)(10)(11) In addition, one report from the literature [38] described the stress degradation of repaglinide and reported six degradation products (DPs 8-13).…”

“…Four DPs (8)(9)(10)(11) In addition, one report from the literature [38] described the stress degradation of repaglinide and reported six degradation products (DPs 8-13). Four DPs (8)(9)(10)(11) In addition, one report from the literature [38] described the stress degradation of repaglinide and reported six degradation products (DPs 8-13). Four DPs (8)(9)(10)(11) were formed under acidic conditions (1M HCl), two DPs (8,9) under basic conditions (1M NaOH), while three DPs (11)(12)(13) were formed under oxidative conditions (30% H 2 O 2 ).…”