Liquid Chromatographic Determination of Norfloxacin in Extended-Release Tablets

Oliveira, Paulo Renato de; Bernardi, Luana; Mendes, Cassiana; Cardoso, Simone Gonçalves; Sangoi, Maximiliano S.; Silva, Marcos A. S.

doi:10.1093/chromsci/47.9.739

Cited by 14 publications

(7 citation statements)

References 25 publications

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“…For the analysis in HPLC of NFX, the parameters followed the descriptions by Oliveira et al [ 44 ]. The chromtographic column used was a Luna ® C 18 150 × 4.6 mm column, with the mobile phase composed of acetonitrile: phosphoric acid 0.04 M pH 3.0 (16:83 v/v) eluted in isocratic mode.…”

Section: Methodsmentioning

confidence: 99%

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Gomes,

Biscaia,

Lopes

et al. 2023

Pharmaceutics

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A solvate cocrystal of the antimicrobial norfloxacin (NFX) was formed by using isonicotinamide (INA) as a coformer with the solvent evaporation technique. The cocrystal formation was confirmed by performing solid-state characterization techniques. We evaluated the dissolution under supersaturated conditions and also the solubility at the vertex of triphasic domain of cocrystal and NFX in both water and Fasted-State Simulated Intestinal Fluid (FaSSIF). The antimicrobial activity was evaluated using the microdilution technique. The cocrystal showed 1.8 times higher dissolution than NFX in water at 60 min and 1.3 times higher in FaSSIF at 180 min in the kinetic study. The cocrystal also had an increase in solubility of 8.38 times in water and 6.41 times in FaSSIF. The biopharmaceutical properties of NFX with cocrystallization improved antimicrobial action, as shown in the results of minimum inhibitory concentration (MIC) and inhibitory concentrations of 50% (IC50%) and 90% (IC90%). This paper presents, for the first time, a more in-depth analysis of the cocrystal of NFX–INA concerning its dissolution, solubility, and antimicrobial activity. In all these criteria, the cocrystal obtained better results compared to the pure drug.

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Section: Methodsmentioning

confidence: 99%

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Gomes,

Biscaia,

Lopes

et al. 2023

Pharmaceutics

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show abstract

“…NFX quantification assay was carried out according to a previously validated method [34]. Briefly, the LC system was operated isocratically at 40°C using a mobile phase composed by phosphoric acid 0.04 M, pH 3.0/acetonitrile (84 : 16; v/v), eluted at a flow rate of 1.0 mL/min.…”

Section: Methodsmentioning

confidence: 99%

Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

Oliveira

Mendes

Klein

et al. 2013

BioMed Research International

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The aim of this research was to develop a new hydrophilic matrix system containing norfloxacin (NFX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxypropylmethylcellulose or poly(ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75 ± 5% relative humidity), and the film-coating process is recommended to avoid NFX photodegradation. The dissolution profiles demonstrated an extended-release of NFX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

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“…MEX quantification assay was carried out according to a previously validated method 34 . Briefly, the LC system was operated isocratically at 40°C using a mobile phase composed by phosphoric acid 0.04M, pH 3.0/acetonitrile (84 : 16; v/v), eluted at a flow rate of 1.0 mL/min.…”

Section: Mex Tablets Assaymentioning

confidence: 99%

Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets

Sihare¹,

Chouksey²

2018

Int J Inn Sci Tech

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The aim of this research was to develop a new hydrophilic matrix system containing meropenem (MEX). Extended-release tablets are usually intended for once-a-day administration with benefits to the patient and lower discontinuation of the therapy. Formulations were developed with hydroxyl propyl methyl cellulose or poly (ethylene oxide) as hydrophilic polymers, with different molecular weights (MWs) and concentrations (20 and 30%). The tablets were found to be stable (6 months at 40 ± 2°C and 75± 5% relative humidity), and the film-coating process is recommended to avoid MEX photo-degradation. The dissolution profiles demonstrated an extended-release of MEX for all developed formulations. Dissolution curves analyzed using the Korsmeyer exponential equation showed that drug release was controlled by both drug diffusion and polymer relaxation or erosion mechanisms. A more erosion controlled system was obtained for the formulations containing lower MW and amount of polymer. With the increase in both MW and amount of polymer in the formulation, the gel layer became stronger, and the dissolution was more drug-diffusion dependent. Formulations containing intermediate MW polymers or high concentration (30%) of low MW polymers demonstrated a combination of extended and complete in vitro drug release. This way, these formulations could provide an increased bioavailability in vivo.

show abstract

Liquid Chromatographic Determination of Norfloxacin in Extended-Release Tablets

Cited by 14 publications

References 25 publications

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Cocrystals Enhance Biopharmaceutical and Antimicrobial Properties of Norfloxacin

Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

Formulation development and Stability Studies of Meropenem Extended-Release matrix Tablets

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