Liquid chromatographic and spectrophotometric methods for the determination of erythromycin stearate and trimethoprim in tablets

Hassib, Sonia T.; Farag, Awatef El-Said; Elkady, Ehab F.

doi:10.1016/j.bfopcu.2011.07.008

Cited by 16 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2b shows that DP plays a discrete role in the ERY oxidation, contributing to 29 % and 13 % in degradation and mineralization, respectively. This finding can be associated to the low absorbance of UV-A radiation by ERY, as ERY is considered a weakly absorbing macrolide antibiotic (Hassib et al, 2011). Studies conducted by Franzen Ramos et al ( 2020) and Rattanapoltaveechai et al (2007) showed that ERY presents a small peak of absorbance at 285 nm (UV-C), far from the radiation emitted by the UV-A lamp used in this work.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 61%

“…As already shown in the literature, depending on the emission spectrum of the artificial irradiation source (UV-A, UV-B or UV-C) and the energy of its photons, ERY can undergo DP, mainly with sources of UV-C radiation (Franzen Ramos et al, 2020;Hassib et al, 2011). Aiming to evaluate the possibility of ERY photolysis, tests were carried out in the reactor (Fig.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

See 1 more Smart Citation

Degradation and mineralization of erythromycin by heterogeneous photocatalysis using SnO2-doped TiO2 structured catalysts: Activity and stability

et al. 2021

View full text Add to dashboard Cite

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 61%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Degradation and mineralization of erythromycin by heterogeneous photocatalysis using SnO2-doped TiO2 structured catalysts: Activity and stability

et al. 2021

View full text Add to dashboard Cite

“…In literature, perchloric and sulfuric acids have been added as reagents on certain macrolides such as erythromycin, spiramycin, troleandomycin and oleandomycin for some spectrofluorimetric and spectrophotometric methods. Perchloric and sulfuric acids help to create chromophores to determine some macrolides [ 13 , 14 , 15 , 16 ]. They promote breaking of large particles into smaller ones with greater quantum yield [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…troleandomycin and oleandomycin for some spectrofluorimetric and spectrophotometric methods. Perchloric and sulfuric acids help to create chromophores to determine some macrolides [13,14,15,16]. They promote breaking of large particles into smaller ones with greater quantum yield [16].…”

Section: Resultsmentioning

confidence: 99%

Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin

El-Yazbi

Khamis

Youssef

et al. 2020

Heliyon

View full text Add to dashboard Cite

Green validated spectrophotometric methods are developed for simultaneous determination of Azithromycin (AZI) and Levofloxacin (LEVO) antibiotic mixture. Determination of AZI presents a real analytical challenge as its structure lacks any chromophore, and hence it cannot be determined by direct spectrophotometry. However, the reaction of AZI with perchloric acid produces a green product that can be accurately determined spectrophotometrically. Thus, the work presented demonstrates simple green and sensitive methods for the simultaneous determination of AZI and LEVO mixture. Method I depends on direct measurement of absorbance of azithromycin and levofloxacin in perchloric acid methanolic solution at 482 nm and 224 nm, respectively. While, Method II depends on measuring the first derivative spectrophotometric peak-to-peak amplitudes of AZI and LEVO in perchloric acid methanolic solution at 475–490 nm and 280–253 nm, respectively. Regression analysis shows good linearity for AZI and LEVO over the concentration ranges of 5–50 and 2.5–20 μg/mL for method I and 5–50 and 5–40 μg/mL for method II for AZI and LEVO, respectively. The proposed methods were validated in compliance with ICH guidelines. The suggested procedures are successfully applied for the assay of AZI and LEVO mixture in bulk powder and laboratory-prepared tablets. Greenness profile of the proposed methods were compared with other published methods through applying the Eco-scale protocol. Assessment results demonstrated that the proposed methods are greener than other reported methods. Moreover, upon comparison with other methods, the proposed methods showed better or comparable sensitivity in addition to being selective and rapid with no requirement for laborious extraction techniques. These advantages encourage the application of the proposed methods in routine analysis of AZI and LEVO in quality control laboratories as green and simple analytical tool.

show abstract

“…Among the different regression method existed for multivariate calibration, the factor analysis based methods including partial least squares (PLS regression and principal component regression (PCR) have received considerable attention in the chemometrics literature [20][21][22][23][24][25] . Due to the overlapped spectra of the drugs, Fig.…”

Section: Chemometric Methodsmentioning

confidence: 99%

Stability Indicating Spectrophotometric and Chemometric Methods for Determination of Buflomedil in Presence of its Acid Induced Degradation Products

Moustafa

Salem

Hegazy

et al. 2013

Analytical Chemistry Letters

View full text Add to dashboard Cite

Simple, accurate, sensitive, selective and validated UV spectrophotometric univariate and multivariate methods were developed for determination of Buflomedil (BFM) in presence of BFM degradation products (BFM Deg). The univariate methods includes mean centering of ratio spectra (MCR), ratio difference spectrophotometric method (RDSM) and H-point standard addition method (HPSAM); the first one used the amplitude at 235.7 nm, the second utilized the difference in amplitudes at 250 nm and 282 nm; while, the third method utilized the absorbance values at 247 and 282.4 nm. Linearity was obtained for the proposed methods in the ranges of 10-100 μgmL-1. The percentage recoveries were 100.06 ± 0.963, 100.17 ± 0.962 and 100.90 ± 0.667 for the three methods in a respective order. Multivariate methods involves the application of three chemometric techniques, and classical least square (CLS) principal component regression (PCR) and partial least-squares regression (PLS), which were used for the simultaneous determination of the BFM and its degradation products. The results obtained from the proposed methods, together with the reported one, were statistically compared using one-way analysis of variance (ANOVA). These methods are suitable as stability indicating methods for the determination of BFM in presence of its degradation products either in bulk powder or in pharmaceutical formulations.

show abstract

Liquid chromatographic and spectrophotometric methods for the determination of erythromycin stearate and trimethoprim in tablets

Cited by 16 publications

References 29 publications

Degradation and mineralization of erythromycin by heterogeneous photocatalysis using SnO2-doped TiO2 structured catalysts: Activity and stability

Degradation and mineralization of erythromycin by heterogeneous photocatalysis using SnO2-doped TiO2 structured catalysts: Activity and stability

Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin

Stability Indicating Spectrophotometric and Chemometric Methods for Determination of Buflomedil in Presence of its Acid Induced Degradation Products

Contact Info

Product

Resources

About