Liquid biopsy = Individualized cancer management: Diagnosis, monitoring treatment and checking recurrence and metastasis

Mali, Shrikant B.; Dahivelkar, Sachinkumar

doi:10.1016/j.oraloncology.2021.105588

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Over the past few decades, exosome-based liquid biopsies have received much attention from clinicians and scientists, with the advantages of easy access, convenience, non-invasiveness, time and effort savings, high reliability, reproducibility, ease of early detection, low cost, and high benefit. 37 They can also track and monitor tumour progression and drug resistance in real time allowing for continuous sampling to provide information on tumour heterogeneity, 114 making it an ideal method for early screening and diagnosis of oral cancer. Figure 2 provides a summary of exosomes as a source of biomarkers for oral cancer diagnosis.…”

Section: Current Status Of Research On Exosomes In the Diagnosis And ...mentioning

confidence: 99%

Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment

Liu¹,

Huang²,

Huang³

et al. 2022

IJN

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Oral cancer is one of the most common cancers in the world, with more than 300,000 cases diagnosed each year, of which oral squamous cell carcinoma accounts for more than 90%, with a 5-year survival rate of only 40–60%, and poor prognosis. Exploring new strategies for the early diagnosis and treatment of oral cancer is key to improving the survival rate. Exosomes are nanoscale lipid bilayer membrane vesicles that are secreted by almost all cell types. During the development of oral cancer, exosomes can transport their contents (DNA, RNA, proteins, etc) to target cells and promote or inhibit the proliferation, invasion, and metastasis of oral cancer cells by influencing the host immune response, drug-resistant metastasis, and tumour angiogenesis. Therefore, exosomes have great potential and advantages as biomarkers for oral cancer diagnosis, and as drug delivery vehicles or targets for oral cancer therapy. In this review, we first describe the biogenesis, biological functions, and isolation methods of exosomes, followed by their relationship with oral cancer. Here, we focused on the potential of exosomes as oral cancer biomarkers, drug carriers, and therapeutic targets. Finally, we provide an insightful discussion of the opportunities and challenges of exosome application in oral cancer diagnosis and treatment, intending to offer new ideas for the clinical management of oral cancer.

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Section: Current Status Of Research On Exosomes In the Diagnosis And ...mentioning

confidence: 99%

Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment

Liu¹,

Huang²,

Huang³

et al. 2022

IJN

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“…Characterized, therapeutically relevant ctDNA alterations can also be found in CCA patients after gene-targeted therapy[ 13 ]. Furthermore, since ctDNA may include DNA shed into the bloodstream from both primary and metastatic tumours, the genomic alterations of ctDNA can reflect the cancer heterogeneity of the whole body better than those found in tissue biopsy[ 14 , 15 ]. Cancer heterogeneity may be part of the reason for the unfavourable outcomes of several gene-targeted trials in CCA[ 16 ].…”

Section: To the Editormentioning

confidence: 99%

Liquid biopsy: Precise diagnosis and therapy for cholangiocarcinoma

Si-qin¹,

Chai²,

Wang³

et al. 2022

WJGO

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“… 62 , 63 Exosomes can track and monitor tumor progression and drug resistance in real-time giving information on drug heterogeneity. 64 A proteome map of human parotid exosomes has also been developed using multi-dimensional protein identification technology, which helps in discovering exosome protein markers related to oral cancer. 65 …”

Section: Introductionmentioning

confidence: 99%

Exosomes: Mediators of cellular communication in potentially malignant oral lesions and head and neck cancers

Solomon,

Chandrashekar,

Kulkarni

et al. 2023

F1000Res

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Exosomes are a unique type of extracellular vesicles that contain a plethora of biological cargo such as miRNA, mRNA, long non-coding RNA, DNA, proteins and lipids. Exosomes serve as very effective means of intercellular communication. Due the presence of a lipid bilayer membrane, exosomes are resistant to degradation and are highly stable. This makes them easily identifiable in blood and other bodily fluids such as saliva. The exosomes that are secreted from a parent cell directly release their contents into the cytoplasm of a recipient cell and influence their cellular activity and function. Exosomes can also transfer their content between cancer cells and normal cells and regulate the tumor microenvironment. Exosomes play a vital role in tumor growth, tumor invasion and metastasis. Exosomes provide a multitude of molecular and genetic information and have become valuable indicators of disease activity at the cellular level. This review explores the molecular characteristics of exosomes and the role that exosomes play in the tumorigenesis pathway of potentially malignant oral lesions and head and neck cancers The application of exosomes in the treatment of oral cancers is also envisioned. Exosomes are very small and can easily pass through various biological barriers, making them very good delivery vectors for therapeutic drugs as well as to selectively induce DNA’s mRNA and miRNAs into targeted cancer cells.

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Liquid biopsy = Individualized cancer management: Diagnosis, monitoring treatment and checking recurrence and metastasis

Cited by 12 publications

References 25 publications

Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment

Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment

Liquid biopsy: Precise diagnosis and therapy for cholangiocarcinoma

Exosomes: Mediators of cellular communication in potentially malignant oral lesions and head and neck cancers

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