Liquid Biopsy for Promising Non-invasive Diagnostic Biomarkers in Parasitic Infections

Öztürk, Emel; Caner, Ayşe

doi:10.1007/s11686-021-00444-x

Cited by 4 publications

(1 citation statement)

References 200 publications

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“…First, their in-depth characterisation (e.g., cargo, surface phenotype, functional properties) can contribute to better understanding how the host responds to the infection, particularly at different stages of disease progression, thus shedding new light on the pathophysiological mechanisms of disease. Second, the characterisation of their cargo and surface phenotype can reveal novel candidate markers for the development of novel diagnostic tests, broadening their utility as liquid biopsies [ 123 ]. Indeed, the presence of specific pathogen-derived antigens or the selective packing of host proteins within EVs could be exploited to improve current diagnostic tests.…”

Section: Concluding Remarks and Future Challengesmentioning

confidence: 99%

Host-Derived Extracellular Vesicles in Blood and Tissue Human Protozoan Infections

Tiberti,

Longoni,

Combes

et al. 2023

Microorganisms

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Blood and tissue protozoan infections are responsible for an enormous burden in tropical and subtropical regions, even though they can also affect people living in high-income countries, mainly as a consequence of migration and travel. These pathologies are responsible for heavy socio-economic issues in endemic countries, where the lack of proper therapeutic interventions and effective vaccine strategies is still hampering their control. Moreover, the pathophysiological mechanisms associated with the establishment, progression and outcome of these infectious diseases are yet to be fully described. Among all the players, extracellular vesicles (EVs) have raised significant interest during the last decades due to their capacity to modulate inter–parasite and host–parasite interactions. In the present manuscript, we will review the state of the art of circulating host-derived EVs in clinical samples or in experimental models of human blood and tissue protozoan diseases (i.e., malaria, leishmaniasis, Chagas disease, human African trypanosomiasis and toxoplasmosis) to gain novel insights into the mechanisms of pathology underlying these conditions and to identify novel potential diagnostic markers.

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Section: Concluding Remarks and Future Challengesmentioning

confidence: 99%