Liquid Biopsies: Emerging role and clinical applications in solid tumours

Sisodiya, Sandeep; Kasherwal, Vishakha; Khan, Asiya; Roy, Bishnudeo; Goel, Anjana; Kumar, Shashank; Arif, Nazneen; Tanwar, Pranay; Hussain, Showket

doi:10.1016/j.tranon.2023.101716

Cited by 8 publications

(2 citation statements)

References 78 publications

(95 reference statements)

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“…Other challenges include the risk of contamination with nontumor DNA, the dynamic nature of tumors that require timely capture for accurate diagnosis, and the economic and accessibility issues associated with cost and availability 39 . Regulatory, ethical, and privacy concerns also play a significant role in the adoption and success of liquid biopsies 51 . The integrity and storage of samples, as well as the interpretation of complex genetic data, are other areas that need to be carefully managed 52 …”

Section: Challenges and Limitations In Diverse Biopsy Fluidsmentioning

confidence: 99%

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Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Bao,

Zhang,

Guo

et al. 2024

Cancer Science

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Liquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and comprehensive approach to cancer diagnostics and management. By harnessing biofluids such as blood, urine, saliva, cerebrospinal fluid, and pleural effusions, this technique profiles key biomarkers including circulating tumor DNA, circulating tumor cells, microRNAs, and extracellular vesicles. This review discusses the extended scope of liquid biopsy, highlighting its indispensable role in enhancing patient outcomes through early detection, continuous monitoring, and tailored therapy. While the advantages are notable, we also address the challenges, emphasizing the necessity for precision, cost‐effectiveness, and standardized methodologies in its broader application. The future trajectory of liquid biopsy is set to expand its reach in personalized medicine, fueled by technological advancements and collaborative research.

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Section: Challenges and Limitations In Diverse Biopsy Fluidsmentioning

confidence: 99%

“… 39 Regulatory, ethical, and privacy concerns also play a significant role in the adoption and success of liquid biopsies. 51 The integrity and storage of samples, as well as the interpretation of complex genetic data, are other areas that need to be carefully managed. 52 …”

Section: Challenges and Limitations In Diverse Biopsy Fluidsmentioning

confidence: 99%