Liquid-based thin-prep cytology study of lacrimal drainage system in primary acquired nasolacrimal duct obstruction

Jang, Jeongkyeong; Choi, Sung‐Eun; Lee, Sang Min

doi:10.1007/s00417-022-05667-w

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…This suggests that mucinous obstruction undergoes fewer secondary changes, such as beading or sac dilation, compared to membranous obstruction, and an inflammatory response occurs below the level of the lacrimal sac. Compared to the prior studies by the authors 10 , a commonality between the current study and the previous research is the focus on investigating the cytological characteristics of Primary Acquired Nasolacrimal Duct Obstruction (PANDO) and emphasizing the utility of the liquid-based thin prep cytology method. However, our study demonstrated a higher cytological detection rate using a modified technique, particularly highlighting distinct features in mucinous obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Transcanalicular dacryoplasty using sheath-guided dacryoendoscopy (RUIDO Fiberscope, Fiber Tech, Tokyo, Japan) was performed, as previously described. 10 As a new addition to the technique, a specimen trap (DONGWHA PANDA, Incheon, Republic of Korea) was used to collect cells that remained in the sheath after passing through the LDS. One side of the specimen trap was connected to the suction line, while the other side was connected to the suction tip.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we analyzed the cytology of PANDO using a liquid-based thin prep cytology method, demonstrating its potential as a noninvasive approach to examining histopathological changes in PANDO. 10 .…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and cytological changes in mucinous obstruction diagnosed by dacryoendoscopy

Kim,

Lew

2024

Sci Rep

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To analyze the clinical characteristics of mucinous obstruction diagnosed by dacryoendoscopy and compared the cytological changes with membranous obstruction using a modified liquid-based thin prep cytology method. A retrospective chart review was conducted on 53 eyes of 51 patients with mucus obstruction based on dacryoendoscopic findings from January 2022 to October 2022. Liquid-based thin-prep cytology was performed by irrigating the inside of the nasolacrimal drainage system with saline during dacryoendoscopy-guided silicone tube intubation. Pathological findings were analyzed through a comparison of mucinous obstruction with membranous obstruction as determined by dacryoendoscopic findings. The modified liquid-based thin prep cytology technique had a higher cytology detection rate across all cases. Mucinous obstruction exhibited a significantly higher number of successful canalicular irrigation test cases compared to membranous obstruction. In mucinous obstruction, epithelial squamous cells were more frequently detected in pre-sac obstruction, whereas columnar epithelial cells were predominant in post-sac obstruction. Inflammatory cells showed a stronger correlation with primary change and post-sac obstruction. Bacterial colonies were observed exclusively in cases of mucinous obstruction. The use of a modified liquid-based thin prep cytology method enables the examination of histopathological changes in the lacrimal passage in primary acquired nasolacrimal duct obstruction (PANDO), particularly in cases of mucinous obstruction, without the need for invasive biopsies. These findings enhance the understanding of the etiopathogenesis of mucinous obstruction, complementing knowledge of membranous obstruction in PANDO.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%