Liquid-based endometrial cytology associated with curettage in the investigation of endometrial carcinoma in a population of 1987 women

Yang, Xi; Ma, Ke; Chen, Rui; Zhao, Jian; Wei, Cheng; Zhang, Naiyi; Ma, Xiuhua; Dong, Ying; Zhu, Siyu; Liao, Qinping

doi:10.1007/s00404-017-4400-2

Cited by 22 publications

(16 citation statements)

References 16 publications

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“…13,29 Additionally, the monolayer preparation of the collected cells may allow for a more comprehensive assessment of the epithelium. 28,30 Previous studies have suggested the Tao brush method as an attractive alternative to endometrial biopsy as it is just as minimally invasive but less uncomfortable 15,20 and more cost effective. 20 The Tao brush cytology specimen is processed in a very similar manner to cervical cytology, which has been an established diagnostic method for several decades.…”

Section: Discussionmentioning

confidence: 99%

Tao brush endometrial cytology is a sensitive diagnostic tool for cancer and hyperplasia among women presenting to clinic with abnormal uterine bleeding

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Tao brush endometrial cytology is a sensitive diagnostic tool for cancer and hyperplasia among women presenting to clinic with abnormal uterine bleeding

et al. 2021

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“…Such high‐risk women are defined as those attending routine cervical screening who are nulligravid or postmenopausal and report abnormal bleeding in the past 6 months 58 . Endometrial cytology requires uterine instrumentation and is therefore less acceptable as a screening tool; however, it is associated with much lower rates of inadequate/failed sampling than endometrial biopsy 59 . Screen‐detected endometrial cancers are also identified at an earlier stage and boast improved survival outcomes compared with women diagnosed following acute symptomatic presentation 58 …”

Section: Screening For Endometrial Cancermentioning

confidence: 99%

Detecting endometrial cancer

Jones

O’Flynn

Njoku

et al. 2021

The Obstetric & Gynaecologis

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Endometrial cancer (EC) is the most common gynaecological cancer in the UK. Ninety percent of women with EC present with postmenopausal bleeding (PMB), but less than 10% of women with PMB have a sinister underlying cause. National Institute for Health and Care Excellence guidance advises that symptomatic postmenopausal women undergo urgent investigation; however, guidance is unclear for premenopausal women. Current investigations for PMB, including transvaginal ultrasound scan, endometrial biopsy and/or outpatient hysteroscopy, have advantages and disadvantages. Novel detection tools are in development, which combine minimally invasive sampling with genomic, proteomic and single cell technologies. Learning objectivesTo understand who is at risk of EC and who should be referred for urgent investigations.To understand the evidence underpinning the current diagnostic pathway for EC. To highlight unique and promising perspectives for EC detection and their potential to transform clinical care. Ethical issuesCurrent diagnostics for EC are invasive and often painful. There is an urgent need for high-quality randomised controlled trials to inform effective pain relief options. Premenopausal women with suspected EC do not fit criteria for urgent investigations. How can we identify those at highest risk to ensure they are fast-tracked appropriately? Novel diagnostic tools hold promise, but they must be robustly validated before being introduced into clinical practice.

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“…This makes liquid-based endometrial cytology, which prepares samples for cytology examination by depositing the collected sample into a preservative liquid, a useful method for detecting endometrial pathologies as a first-line approach compared to the more invasive, painful and expensive endometrial biopsy, D&C and hysteroscopy. Cytology sampling performed by brushing the uterus cavity followed by a liquid-based smear has demonstrated an optimal diagnostic accuracy [23]. …”

Section: Liquid Biopsy In Endometrial Cancermentioning

confidence: 99%

Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology

Muinelo‐Romay

Casas-Arozamena

Abal

2018

IJMS

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The identification of new molecular targets and biomarkers associated with high risk of recurrence and response to therapy represents one of the main clinical challenges in the management of advanced disease in endometrial cancer. In this sense, the field of liquid biopsy has emerged as a great revolution in oncology and is considered “the way” to reach personalised medicine. In this review, we discuss the promising but already relatively limited advances of liquid biopsy in endometrial cancer compared to other types of tumours like breast, colorectal or prostate cancer. We present recent data analysing circulating tumour material in minimally-invasive blood samples, but also in alternative forms of liquid biopsy like uterine aspirates. Proteomic and genomic studies focused on liquid-based uterine samples are resulting not only in optimal diagnostic tools but also in reliable approaches to address tumour heterogeneity. Likewise, circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) represent an opportunity for the correct stratification of patients, for the assessment of early recurrent disease or for the real-time monitoring of therapy responses. Appropriately designed studies and implementation in clinical trials will determine the value of liquid biopsy for precision oncology in endometrial cancer.

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Liquid-based endometrial cytology associated with curettage in the investigation of endometrial carcinoma in a population of 1987 women

Abstract: Liquid-based endometrial cytology can be considered a useful method for detecting of endometrial pathology as a first-line approach.

Cited by 22 publications

References 16 publications

Tao brush endometrial cytology is a sensitive diagnostic tool for cancer and hyperplasia among women presenting to clinic with abnormal uterine bleeding

Tao brush endometrial cytology is a sensitive diagnostic tool for cancer and hyperplasia among women presenting to clinic with abnormal uterine bleeding

Detecting endometrial cancer

Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology

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