Liquid-Based Cytology Findings of Glassy Cell Carcinoma of the Cervix

Ng, Wai-Kuen; Cheung, Leslie K. N.; Li, Albert S. M.

doi:10.1159/000326293

Cited by 11 publications

(2 citation statements)

References 24 publications

(13 reference statements)

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“…In terms of HPV prevalence or a causative role in GCC, there have been a few studies predominantly using PCR primers for HPV-16 or HPV-18 (17)(18)(19)(20). Although HPV prevalence by genotyping in GCC remains controversial for small numbers and limited typing, the overall prevalence was 8/23 (34.8%).…”

Section: Discussionmentioning

confidence: 99%

Glassy Cell Carcinoma Predominantly Commits to a Squamous Lineage and is Strongly Associated With High-risk Type Human Papillomavirus Infection

Kim

Shim

Lee

et al. 2009

International Journal of Gynecological Pathology

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Glassy cell carcinoma (GCC) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. This study includes immunoprofiles of p63, cytokeratin 17 (CK17), and CD44 to clarify which lineage of GCC is committed to human papillomavirus (HPV) detection, and to verify whether or not HPV plays a role in GCC. Nine uterine GCCs showing overwhelmingly glassy features were evaluated by an HPV genotyping chip and by immunohistochemistry for E-cadherin, CD44, p63, CEA, erb-B2, cytokeratin 17, and p16. An HPV genotyping DNA chip array with multiple oligonucleotide probes of L1 sequences from 26 types of HPV was introduced. GCCs were variably stained, except for CD44 which was stained unanimously. A lack of E-cadherin was found in 4 cases, frequent expression of p63 in 6/9 (66.7%), mucin stain or CEA in 5/9 (55.6%), and coexpression of p63 in 4. HPV prevalence in GCC was found in 6/9 cases (66.7%). HPV-18 and HPV-32 were the most common types detected. The remaining cancers were infected by HPV-31, HPV-35, HPV-39, and HPV-68. Multiple infections were found in 2 out of 6 cases. GCC could not be precisely categorized, but was committed to squamous lineages and was strongly associated with high-risk type HPV infection.

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Section: Discussionmentioning

confidence: 99%

Glassy Cell Carcinoma Predominantly Commits to a Squamous Lineage and is Strongly Associated With High-risk Type Human Papillomavirus Infection

Kim

Shim

Lee

et al. 2009

International Journal of Gynecological Pathology

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“…The treatment of choice of Stages I and II cervical GCC less than 2 cm, is radical hysterectomy with bilateral pelvic lymphadenectomy, while removing the lymph nodes around the common iliac, internal and external iliac vessels, and anterior to the obturator nerve [20]. In case of pelvic lymph node involvement, inframesenteric lumbaraortic dissection is indicated [21].…”

Section: Discussionmentioning

confidence: 99%

Glassy cell carcinoma: is surgical treatment with preservation of the uterus a therapeutic option

2020

EJGO

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Glassy cell carcinoma (GCC) is a rare and aggressive type of adenoSquamous cervical carcinoma. It affects patients at a younger age compared to the general population of patients with cervical cancer. The five-year survival is inferior to that of the other histological types. The treatment is not standardized. Radiation therapy with concomitant chemotherapy is associated with a better local control and improves oncological results. The authors report here the clinical histories of two patients with an early GCC and a desire of fertility preservation treated with radical trachelectomy with an early recurrence. They conclude that considering the rarity and aggressivity of this histological type, and the lack of evidence in the literature for its management, it would be prudent to consider GCC at an early stage as a contraindication for a radical trachelectomy.

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Cytology of Glandular Lesions

Smith

2014

Cellular Pathology of Glandular Lesions and Uncommon Neoplasms of the Cervix

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Liquid-Based Cytology Findings of Glassy Cell Carcinoma of the Cervix

Cited by 11 publications

References 24 publications

Glassy Cell Carcinoma Predominantly Commits to a Squamous Lineage and is Strongly Associated With High-risk Type Human Papillomavirus Infection

Glassy Cell Carcinoma Predominantly Commits to a Squamous Lineage and is Strongly Associated With High-risk Type Human Papillomavirus Infection

Glassy cell carcinoma: is surgical treatment with preservation of the uterus a therapeutic option

Cytology of Glandular Lesions

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