Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from Liqui-Pellets

Lam, Matthew; Nashed, Nour; Nokhodchi, Ali

doi:10.3390/pharmaceutics13071049

Cited by 3 publications

(1 citation statement)

References 26 publications

(46 reference statements)

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“…A liqui-tablet with sustained release over 24 hours was obtained by incorporating a suitable polymer, in this case Eudragit ® RS PO, into the liqui-mass system. It was emphasized that sustained drug release from liqui-tablets can be attributed to the synergistic retarding effect of the liquid vehicle and polymer, with the concentration of polymer recognized as the most important variable (82).…”

Section: Novel Liquisolid-based Techniquesmentioning

confidence: 99%

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Aleksić¹,

Glišić²,

Parojčić³

2022

Arhiv za farmaciju

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Liquisolid systems are a novel, promising platform for the production of solid dosage forms with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid vehicle or liquid drug. This technology requires conventional, but highly porous excipients (carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication, resulting in both good flowability and acceptable compression properties. This approach has shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs, and has been recognized as a good alternative to common, more complex and expensive techniques. A variety of applications of this simple technique have been investigated recently, including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and the most important are: simplicity, cost-effectiveness, applicability in large scale production and environmental friendliness. However, it is accompanied by certain challenges as well, such as limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive overview of recent progress regarding the potential applications of this technology, as well as to give an insight into the new liquisolid-based techniques intending to further support its commercial applicability.

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Section: Novel Liquisolid-based Techniquesmentioning

confidence: 99%

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Aleksić¹,

Glišić²,

Parojčić³

2022

Arhiv za farmaciju

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Liqui-pellets as a Novel Approach in the Formulation of Oral Solid Products

Rao,

et al. 2023

Scopus Indexed

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In dosage form design, rather particular interest is shown towards solid oral products as they are versatile and highly preferred by the pharmaceutical manufacturing industry. To tackle poor dissolution and bioavailability of problematic drugs, liquisolid technology is developed, from which further advances like liqui-pellet's originated. The latter requires lower economic investment than the liquisolid formulation technology. Some limitations in the liquisolid technology are inadequate flowability, compressibility and the inability to manufacture high-dose oral products, which are very difficult to administer. Overall, the liqui-pellets would overcome the inadequate flowability of the liquisolid formulation adding a better drug release ability. These problems can be resolved by employing the liqui-pellets. This review article provides information about liqui-pellets' advantages, the preparation method, factors affecting them and evaluation studies. The main background areas like liquisolid technology, extrusion and spheronization technology are also discussed. The liqui-pellet system is a significant innovation in oral solid drug products.

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An Overview on Liquisolid Technique: Its Development and Applications

Rashad

Louis

2022

Ther. Deliv.

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With its simplicity and cost–effectiveness, the liquisolid technique offers solutions for numerous formulation problems. Among these are dissolution enhancement and sustaining drug release, and the liquisolid technique dealt with both approaches. This review focuses on the latest advances in the technique. It discusses modified additives for use as carrier materials, which secure the required large surface area for enclosing liquids. The review also covers the modern liquipellet technique derived from the extrusion/palletization technique. Also, the liquiground term is introduced, combining the advantages of co-grinding with the liquisolid concept. Furthermore, several grades of Eudragits, and hydrophilic retarding polymers are mentioned to explain modes of sustaining drug release. This review sums up the liquisolid technique development and its applications recently achieved.

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Liqui-Mass Technology as a Novel Tool to Produce Sustained Release Liqui-Tablet Made from Liqui-Pellets

Cited by 3 publications

References 26 publications

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives

Liqui-pellets as a Novel Approach in the Formulation of Oral Solid Products

An Overview on Liquisolid Technique: Its Development and Applications

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