Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti-Candida agent

Baldim, Iara; Tonani, Ludmilla; Kress, Márcia Regina von Zeska; Oliveira, Wanderley Pereira de

doi:10.1016/j.indcrop.2018.10.064

Cited by 48 publications

(33 citation statements)

References 54 publications

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“…The GC-MS results permitted the detection of twenty-seven compounds of the Lippia sidoides EO, and 26 were successfully identified (see Table 2), corresponding to 99.94% of the EO composition, as reported previously by us [19] and according to the equipment library. Thymol, the bioactive compound linked to most of the biological activities of Lippia sidoides [50], was confirmed as the most abundant component, with a concentration of 68.2%, as previously reported in the literature [51][52][53].…”

Section: Resultssupporting

confidence: 69%

“…The main constituents of Lippia sidoides EO were characterized by gas chromatography coupled to mass spectrometry (GC-MS Shimadzu QP-2010, Kyoto, Japan), using an DB-5 (30 m × 0.25 mm × 0.25 µm) capillary column. The chromatographic conditions were based on previous study [19]. Hydrogen was used as the carrier gas, temperature-programmed from 60 • C to 240 • C with a ramp of 3 • C min −1 .…”

Section: Characterization Of the Major Constituents Of The Lippia Sidmentioning

confidence: 99%

“…Encapsulation into lipid nanoparticles is receiving significant attention in the pharmaceutical and food sectors, as they offer several advantages, namely their biocompatibility, biodegradability and low toxicity, the possibility to encapsulate hydrophilic and lipophilic compounds, low production costs and easy scale-up [19][20][21][22][23]. Lipid nanoparticles are classified into different types produced by very different lipids and by different methods [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Factors Affecting the Retention Efficiency and Physicochemical Properties of Spray Dried Lipid Nanoparticles Loaded with Lippia sidoides Essential Oil

et al. 2020

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Essential oils (EOs) are widely used in various industrial sectors but can present several instability problems when exposed to environmental factors. Encapsulation technologies are effective solutions to improve EOs properties and stability. Currently, the encapsulation in lipid nanoparticles has received significant attention, due to the several recognized advantages over conventional systems. The study aimed to investigate the influence of the lipid matrix composition and spray-drying process on the physicochemical properties of the lipid-based nanoparticles loaded with Lippia sidoides EO and their retention efficiency for the oil. The obtained spray-dried products were characterized by determination of flow properties (Carr Index: from 25.0% to 47.93%, and Hausner ratio: from 1.25 to 1.38), moisture (from 3.78% to 5.20%), water activity (<0.5), and powder morphology. Zeta potential, mean particle size and polydispersity index, of the redispersed dried product, fell between −25.9 mV and −30.9 mV, 525.3 nm and 1143 nm, and 0.425 and 0.652, respectively; showing slight differences with the results obtained prior to spray-drying (from −16.4 mV to −31.6 mV; 147 nm to 1531 nm; and 0.459 to 0.729). Thymol retention in the dried products was significantly lower than the values determined for the liquid formulations and was affected by the drying of nanoparticles.

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Section: Resultssupporting

confidence: 69%

Section: Characterization Of the Major Constituents Of The Lippia Sidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Affecting the Retention Efficiency and Physicochemical Properties of Spray Dried Lipid Nanoparticles Loaded with Lippia sidoides Essential Oil

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“…This is particularly desirable since prepared products are considered to enhance dispersibility in aqueous medium and improve stability of bioactive compounds compared with pure extract. LE and HSDP samples gave MIC of 312.5 μg/mL, well below ≤ 1000 μg/mL, the value suggested for plant extracts (86,87), and hence, were considered effective against the test microorganism. ROA gave no activity at used concentration range which is several folds higher than its concentration in the extract.…”

Section: Antifungal Assaymentioning

confidence: 82%

Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols

et al. 2020

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This work aims to improve the functionality of Rosmarinus officinalis L. (rosemary) polyphenols by encapsulation in an optimized proliposome formulation. A 2 3 Box-Wilson central composite design (CCD) was employed to determine lone and interaction effects of composition variables on moisture content (X p); water activity (A w); concentration and retention of rosemary polyphenols-rosmarinic acid (ROA), carnosol (CAR), and carnosic acid (CNA); and recovery of spray-dried proliposomes (SDP). Processing conditions which generate proliposomes with optimum physicochemical properties were determined by multi-response analysis (desirability approach). Antioxidant and antifungal activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH •) sequestering and minimum inhibitory concentration (MIC)/minimum fungicidal concentration (MFC) assays, respectively. SDP exhibited high polyphenol retention, ranging from 62.0 to 100.0% w/w, showing dependence on composition variables and polyphenol lipophilicity. SDP recovery ranged from 20.1 to 45.8%, with X p and A w of 1.7 ± 0.14-2.5 ± 0.23% w/w and 0.30 ± 0.004-0.47 ± 0.003, respectively, evidencing product with good chemical and microbiological stability. Optimum liposomal composition was determined, namely, lipid concentration (4.26% w/w), lyophilized extract (LE) concentration (4.48% w/w), and drying aid:(lipid+extract) ratio (7.55% w/w) on wet basis. Relative errors between experimental and predicted values for SDP properties showed concurrence for all responses except CAR retention, being 22% lower. SDP showed high antioxidant activity with IC 50 of 9.2 ± 0.2 μg/ mL, superior to results obtained for LE (10.8 μg/mL) and butylated hydroxytoluene (BHT), a synthetic antioxidant (12.5 μg/mL). MIC and MFC against Candida albicans (ATCC1023) were 312.5 μg/mL and 1250 μg/mL, respectively, a moderate antimicrobial activity for phytochemical-based products. SDP is shown as a veritable tool to encapsulate hydrophilic and lipophilic rosemary polyphenols generating a product with optimal physicochemical and biological properties.

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“…The essential oils of L. sidoides contain as major compounds thymol and carvacrol (Melo et al, 2011), which have anti-infective, antiseptic, and anti-inflammatory properties (Botelho et al, 2016), and may be used as insecticides (Figueiredo et al, 2017), acaricides (Camilo et al, 2017), and as fungicides and fungiostatics (Baldim et al, 2019;Ferreira et al, 2018). The larvicidal effect of L. sidoides essential oils on A. aegypti was observed at concentrations (LC 50 ) ranging from 3.74 to 3.85mg/ml -1 (Furtado, 2005) and 25.5μg/ml -1 (de Lima et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effects of Lippia sidoides Cham. (Verbenaceae) essential oils on the honey bees, Apis mellifera (Apidae: Hymenoptera), foraging

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Souza

et al. 2019

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The use of plant essential oils has been adopted as less hazardous to the environment and human health than synthetic insecticides used for the control of insects that transmit diseases. Despite of exerting insecticidal activities against several insect disease vectors, the potential impacts on non-target organisms exerted by essential oils extracted from Lippia sidoides (Cham.) have not received adequate attention. Here, we evaluated the susceptibility and potential changes in consumption rates of honey bees, Apis mellifera (L.), when exposed to essential oils extracted from L. sidoides. Was exposed forager bees to honey syrup (50% v/v) containing L. sidoides essential oil for 5 h. After this exposure period, the bees received regular honey syrup for another 19 h period. Six essential oil concentrations was used, namely 1.0, 1.5, 2.0, 2.5, 3.0 and 3.5 µL of essential oil/mL of syrup, and evaluated the syrup consumption and bees mortality in both periods (at the 5th and 24th h). The results reveal that independent of the essential oil concentration, the forager bees fed significantly less on L. sidoides essential oil-containing honey syrup. However, feeding on L. sidoides essential oil-containing honey syrup did not cause significant mortality when compared with bees that were not exposed to the essential oils. Thus, the results demonstrate that L. sidoides essential oils exhibited adequate selectivity against honey bees.

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Lippia sidoides essential oil encapsulated in lipid nanosystem as an anti-Candida agent

Cited by 48 publications

References 54 publications

Factors Affecting the Retention Efficiency and Physicochemical Properties of Spray Dried Lipid Nanoparticles Loaded with Lippia sidoides Essential Oil

Factors Affecting the Retention Efficiency and Physicochemical Properties of Spray Dried Lipid Nanoparticles Loaded with Lippia sidoides Essential Oil

Spray-Dried Proliposomes: an Innovative Method for Encapsulation of Rosmarinus officinalis L. Polyphenols

Effects of Lippia sidoides Cham. (Verbenaceae) essential oils on the honey bees, Apis mellifera (Apidae: Hymenoptera), foraging

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