Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone resorption in experimental periodontitis in rats

Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

Section: Myracrodruon Urundeuva Allemão Anacardiaceae (Aroeira-do-sementioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

“…They disclosed that these activities are partly due to its antioxidant action, known to be linked to the presence of polyphenols, including tannins (Morais et al, 2005). Botelho et al (2007) examined the effect of topical herbal gel from Lippia sidoides 0.5% (v/w) and M. urundeuva 5% (w/w) in experimental periodontal disease in rats showing potential as a treatment for reducing tissue lesions (Souza et al, 2006). The chalcone dimers urundeuvina A and B were isolated from the inner bark of a specimen of M. urundeuva (Botelho et al, 2007) together with the antioxidant compounds cicloeucalenol and cicloeucalenona (Bandeira et al, 1994).…”

Section: In Vitro Cytotoxic Activity Of Brazilian Middle West Plant Ementioning

confidence: 99%

“…Botelho et al (2007) examined the effect of topical herbal gel from Lippia sidoides 0.5% (v/w) and M. urundeuva 5% (w/w) in experimental periodontal disease in rats showing potential as a treatment for reducing tissue lesions (Souza et al, 2006). The chalcone dimers urundeuvina A and B were isolated from the inner bark of a specimen of M. urundeuva (Botelho et al, 2007) together with the antioxidant compounds cicloeucalenol and cicloeucalenona (Bandeira et al, 1994). Fruits of Schinus terebinthifolius are spices used to increase flavor in food worldwide (Viana et al, 2003).…”

Section: In Vitro Cytotoxic Activity Of Brazilian Middle West Plant Ementioning

confidence: 99%

In vitro cytotoxic activity of Brazilian Middle West plant extracts

Mahmoud¹,

Marques²,

Pessoa³

et al. 2011

Cytotoxic activity of eight plant extracts, native from the MidWest of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL -1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL -1 ) was used as the positive control and the MTT method was used to detect the activity. Cytotoxicity of distinct polarities was observed in thirty extracts (46%), from different parts of the following species: Tabebuia heptaphylla (Vell.) Toledo, Bignoniaceae, Tapirira guianensis Aubl., Anacardiaceae, Myracrodruon urundeuva Allemão, Anacardiaceae, Schinus terebinthifolius Raddi, Anacardiaceae, Gomphrena elegans Mart., Amaranthaceae, Attalea phalerata Mart. ex Spreng., Arecaceae, Eugenia uniflora L., Myrtaceae, and Annona dioica A. St.-Hil., Annonaceae. Extracts of at least two tested cell strains were considered to be highly active since their inhibition rate was over 75%.

“…Botelho et al (2007c) have shown that C. albicans, was susceptible to Lippia sidoides essential oil and pure thymol and carvacrol. They also tested the and can cause significant tissue damage followed by other vascular phenomena mediated by inflammatory compounds (Botelho et al, 2007a).…”

Section: Microorganismmentioning

confidence: 99%

“…The increasing resistance developments with available antimicrobials have drawn the attention of the scientifi c community to search for new and effective drugs from natural origin (Botelho et al, 2007a). Essential oils exert many properties such as antinociceptive (Franco et al, 2011), anticonvulsant (Oliveira, 2009), cardiovascular effects (Menezes et al, 2010), antimicrobial activity against cariogenic bacteria (Botelho et al, 2009a) and fungal fi laments as well (Botelho et al, 2007b).…”

Section: Introductionmentioning

confidence: 99%

Phythochemical screening and antimicrobial activity phythochemical of essential oil from Lippia gracillis

Bitu¹,

Botelho²,

Costa³

et al. 2012

Abstract:The chemical composition of the essential oil obtained from the fresh and dried leaves of Lippia gracillis Schauer, Verbenaceae, was analyzed by gas chromatography and gas chromatography/mass spectrometry (GC⁄MS). The yield of essential oil extracted from the dried leaves was significantly higher (p<0.05) when compared to the fresh leaves. Seventeen components were identified. The monoterpenes and sesquiterpene hydrocarbons with 96.26% (w/w) of the total oil obtained of fresh leaves and 86.99% (w/w) of the total oil obtained of dried leaves were the principal compound groups. Thymol was observed dominant (44.42%; 21.3%), followed by carvacrol (22.21%; 21.30%), p-cymene (6.23%; 8.58%), α-pinene (5.65%; 19.42%), β-caryophyllene (5.61%; 3.57%) and other minor constitutes, respectively. Microbiological results obtained by agar diffusion method, micro dilution method and minimum inhibitory concentration (MIC) showed that the essential oil has a relevant antimicrobial activity against E. coli (ATCC 10536), E. coli (Ec 27), Pseudomonas aeruginosa (ATCC 15442), S. aureus (ATCC 12692) and S. aureus (Sa 358), with their inhibition zones ranging from 9 to 13 mm and the MIC ranging from 64 to 512 μg/mL.