Lipoxin A4: a novel anti-inflammatory molecule?

Lee, T H

doi:10.1136/thx.50.2.111

Cited by 18 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Surprisingly, SAA is also a G-protein-coupled receptor (FPLR1/LXA4R) agonist. The FPLR1/LXA4R receptor is unusual, because it is shared by two ligands, both the inflammatory bacterial formyl peptide and also the antiinflammatory eicosanoid, lipoxin A4 (57). Lipoxins have recently been recognized as important inflammation-resolving mediators.…”

Section: Discussionmentioning

confidence: 99%

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Bozinovski¹,

Hutchinson²,

Thompson³

et al. 2008

Am J Respir Crit Care Med

224

163

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Bozinovski¹,

Hutchinson²,

Thompson³

et al. 2008

Am J Respir Crit Care Med

224

163

View full text Add to dashboard Cite

show abstract

“…LXA 4 can also enhance adhesivity of endothelial cells for PMN in vitro [7]. Other studies have documented anti-inflammatory actions of lipoxins at nanomolar ranges, for example that LXA 4 inhibits both PMN and eosinophil chemotaxis [8,9], and PMN migration across epithelial cells when the process is elicited by means of leukotriene B 4 [5S,12R-dihydroxy-6,14-cis-8,10-transeicosatetraenoic acid; LTB 4 ] or the formyl peptide FMLP [10,11]. Lipoxins are rapidly and enzymatically transformed by different pathways in human monocytes (but less so in neutrophils) that give rise to metabolic products that are essentially inactive [12,13].…”

Section: Introductionmentioning

confidence: 99%

Interactions Between Lipoxin A₄, the Stable Analogue 16‐phenoxy‐lipoxin A₄ and Leukotriene B₄ in Cytokine Generation by Human Monocytes

et al. 2004

View full text Add to dashboard Cite

Lipoxins display both stimulatory and inhibitory actions with leucocytes that are cell-type dependent. We tested whether lipoxin A 4 (LXA 4 ) and its stable synthetic analogue 19, ) modulated the ability of human blood monocytes (MO) to express mRNA and proteins for interleukin-1b (IL-1b), IL-6 and IL-1 receptor antagonist (IL-1Ra) in vitro and compared their actions with lipopolysaccharide (LPS) and leukotriene B 4 (LTB 4 ). 16-phe-LXA 4 , LPS and LTB 4 , but not LXA 4 , induced gene expression of IL-1b in MO. IL-1b protein synthesis increased by LPS (1500-fold), LTB 4 (280-fold) and 16-phe-LXA 4 (30-fold). Although the IL-1Ra gene was constitutively activated, mRNA concentration not affected by any of the stimulants, IL-Ra protein synthesis was increased by LPS (with 74%), 16-phe-LXA 4 (35%) and LTB 4 (20%), but not by LXA 4 . Each of these stimuli upregulated the IL-6 gene. Increases of IL-6 protein were 3000-fold for LPS, threefold for 16-phe-LXA 4 , eightfold for LXA4 and twofold for LTB 4 . Prior exposure of MO to 16-phe-LXA 4 , but not LXA 4 , reduced LTB 4 induced synthesis of IL-1b with 66%, IL-6 with 20% and IL-1Ra with 29%. Thus, a stable LXA analogue, that resists rapid inactivation by monocytes, displays novel actions in cytokine generation, intimately involved in the regulation of inflammation.

show abstract

“…This suggests that the increase in alox‐12/15 expression may be considered as a good indicator associated with protection in adult rats. The alox15 pathway is of particular interest as it is a key enzyme in the formation of Lipoxin A4, which is induced during inflammation and cell–cell interactions (Lee, 1995). Lipoxin A4 has been implicated as a powerful anti‐inflammation component and limits tissue injury (Levy et al ., 2001; Lawrence et al ., 2002).…”

Section: Discussionmentioning

confidence: 99%

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection

Pierrot¹,

Vampouille²,

Vandomme

et al. 2011

Cellular Microbiology

View full text Add to dashboard Cite

SummaryOur previous studies have shown that Plasmodium berghei infection induces distinct clinical, parasitological and immunological states in young susceptible rats versus adult resistant rats. This susceptibility was mainly found to be related to inadequate cellular responses. In this study we first identified the altered genes in young susceptible rats. Unexpectedly, transcriptome analysis did not reveal any alteration of effector cytokines or their receptors. At day 13 p.i., six transcripts corresponding to faim3, mesothelin, gas3 (PMP22), gas7, CD24 and P2Y6R were significantly decreased in young infected rats when compared with adult infected rats. Because CD24 and P2Y6R participate in cellular immune responses, we next evaluated their role in the course of infection. Adoptive transfer experiments showed a transient but robust participation of CD24+ cells in the control of parasitaemia. The role of P2Y6R was investigated via its specific ability to be activated by Uridine di-Phosphate (UDP). Young rats treated with UDP partially restored the expression of P2Y6R, controlled parasitaemia and survived thereafter. In conclusion, this study contributes to the discovery of novel biomarkers in young susceptible rats and suggests that the decrease in their expression could be among the reasons for the development of severe pathology in malaria.

show abstract

Lipoxin A4: a novel anti-inflammatory molecule?

Cited by 18 publications

References 25 publications

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Interactions Between Lipoxin A₄, the Stable Analogue 16‐phenoxy‐lipoxin A₄ and Leukotriene B₄ in Cytokine Generation by Human Monocytes

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection

Contact Info

Product

Resources

About

Lipoxin A4: a novel anti-inflammatory molecule?

Cited by 18 publications

References 25 publications

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Serum Amyloid A Is a Biomarker of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Interactions Between Lipoxin A4, the Stable Analogue 16‐phenoxy‐lipoxin A4 and Leukotriene B4 in Cytokine Generation by Human Monocytes

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection

Contact Info

Product

Resources

About

Interactions Between Lipoxin A₄, the Stable Analogue 16‐phenoxy‐lipoxin A₄ and Leukotriene B₄ in Cytokine Generation by Human Monocytes