Lipoteichoic Acid (LTA) and Lipopolysaccharides (LPS) from Periodontal Pathogenic Bacteria Facilitate Oncogenic Herpesvirus Infection within Primary Oral Cells

Dai, Lu; Defee, Michael; Cao, Yunxia; Wen, Jin‐Kun; Wen, Xiaofei; Noverr, Mairi C.; Qin, Zhiqiang

doi:10.1371/journal.pone.0101326

Cited by 32 publications

(33 citation statements)

References 77 publications

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“…Also, Epstein–Barr virus reactivation may trigger overgrowth of P. gingivalis and, bidirectionally, P. gingivalis has the potential to reactivate Epstein–Barr virus with the risk of generating and disseminating infectious virions . Porphyromonas gingivalis lipopolysaccharide may facilitate herpesviral entry into periodontal fibroblasts and activate intracellular signaling pathways, such as nuclear factor‐kappaB , and butyric acid and other products of P. gingivalis may reactivate Epstein–Barr virus by acetylation of histone proteins and by other means of epigenetic changes . The vicious cycle of increased pathogenicity of both herpesviruses and pathogenic bacteria may lead to periodontal breakdown if the herpesvirus–bacterial collaboration is not swiftly controlled by host defenses or by therapy.…”

Section: Herpesvirus Pathogenicitymentioning

confidence: 99%

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Slots¹

2015

Periodontology 2000

111

164

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Periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. Herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. In 26 recent studies from 15 countries, subgingival cytomegalovirus, Epstein-Barr virus and herpes simplex virus type 1, respectively, yielded median prevalences of 49%, 45% and 63% in aggressive periodontitis, 40%, 32% and 45% in chronic periodontitis, and 3%, 7% and 12% in healthy periodontium. An active herpesvirus infection of the periodontium exhibits site specificity, is a potent stimulant of cellular immunity, may cause upgrowth of periodontopathic bacteria and tends to be related to disease-active periodontitis. Pro-inflammatory cytokines induced by the herpesvirus infection may activate matrix metalloproteinases and osteoclasts, leading to breakdown of the tooth-supportive tissues. The notion that a co-infection of herpesviruses and specific bacteria causes periodontitis provides a plausible etiopathogenic explanation for the disease. Moreover, herpesvirus virions from periodontal sites may dislodge into saliva or enter the systemic circulation and cause diseases beyond the periodontium. Periodontal treatment can diminish significantly the periodontal load of herpesviruses, which may lower the incidence and magnitude of herpesvirus dissemination within and between individuals, and subsequently the risk of acquiring a variety of medical diseases. Novel and more effective approaches to the prevention and treatment of periodontitis and related diseases may depend on a better understanding of the herpesvirus-bacteria-immune response axis.

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Section: Herpesvirus Pathogenicitymentioning

confidence: 99%

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Slots¹

2015

Periodontology 2000

111

164

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“…Moreover, interaction between EBV and Porphyromonas gingivalis may also be bidirectional [123]. Herpesviral proteins on infected cells may serve as a new attachment sites for bacteria [124], while some bacterial products may facilitate herpesviral entry into cells and activate intracellular signalling pathways [125].…”

Section: Discussionmentioning

confidence: 99%

Herpesviruses in Periapical Pathoses: An Updated Systematic Review

Jakovljević¹,

Andrić²,

Knežević³

et al. 2016

Herpesviridae

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Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evaluation, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.

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“…*, P Ͻ 0.05; **, P Ͻ 0.01. with 20% fetal bovine serum. Primary human umbilical vein endothelial cells (HUVEC) were cultured as described previously (7). All the cells were cultured at 37°C in 5% CO 2 .…”

Section: Fig 5 Legend (Continued)mentioning

confidence: 99%

Regulation of Virus-Associated Lymphoma Growth and Gene Expression by Bacterial Quorum-Sensing Molecules

Qiao

Cao

Zabaleta

et al. 2018

J Virol

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Kaposi's sarcoma-associated herpesvirus (KSHV) can cause several human cancers, including primary effusion lymphoma (PEL), which frequently occur in immunocompromised patients. KSHV-infected patients often suffer from polymicrobial infections caused by opportunistic bacterial pathogens. Therefore, it is crucial to understand how these coinfecting microorganisms or their secreted metabolites may affect KSHV infection and the pathogenesis of virus-associated malignancies. Quorum sensing (QS), a cell density-based intercellular communication system, employs extracellular diffusible signaling molecules to regulate bacterial virulence mechanisms in a wide range of bacterial pathogens, such as , which is one of the most common opportunistic microorganisms found in immunocompromised individuals. In this study, we evaluated and compared the influence on PEL growth and the host/viral interactome of the major QS signaling molecules [-(3-oxododecanoyl)-l-homoserine lactone (OdDHL), -butyrylhomoserine lactone (BHL), and 2-heptyl-3-hydroxy-4-quinolone (PQS)] in conditioned medium from wild-type (wt) and QS mutant laboratory strains as well as clinical isolates of Our data indicate that coinfection may facilitate virus dissemination and establishment of new infection and further promote tumor development through effectively inducing viral lytic gene expression by its QS systems. Currently, most studies about KSHV infection and/or virus-associated malignancies depend on pure culture systems or immunodeficient animal models. However, the real situation should be much more complicated in KSHV-infected immunocompromised patients due to frequent polymicrobial infections. It is important to understand the interaction of KSHV and coinfecting microorganisms, especially opportunistic bacterial pathogens. Here we report for the first time that and its quorum-sensing signaling molecules display a complicated impact on KSHV-associated lymphoma growth as well as the intracellular host/viral gene expression profile. Our data imply that targeting of coinfecting pathogens is probably necessary during treatment of virus-associated malignancies in these immunocompromised patients.

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Lipoteichoic Acid (LTA) and Lipopolysaccharides (LPS) from Periodontal Pathogenic Bacteria Facilitate Oncogenic Herpesvirus Infection within Primary Oral Cells

Cited by 32 publications

References 77 publications

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Periodontal herpesviruses: prevalence, pathogenicity, systemic risk

Herpesviruses in Periapical Pathoses: An Updated Systematic Review

Regulation of Virus-Associated Lymphoma Growth and Gene Expression by Bacterial Quorum-Sensing Molecules

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