Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Schühle, Daniel T.; Rijn, Patrick van; Laurent, Sophie; Elst, Luce Vander; Müller, Robert N.; Stuart, Marc C. A.; Schatz, J.; Peters, Joop A.

doi:10.1039/c0cc00107d

Cited by 28 publications

(19 citation statements)

References 12 publications

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“…Indeed, amphiphilic calixarenes have already been demonstrated to preferentially distribute in the outer leaflet of liposomes without varying the liposomal dimensions. [27] Interestingly, the most stable pseudorotaxane, that is, 2, [28] has the most negative z-potential values. It is noteworthy that 5 is charged as well as 2-4, but nevertheless, the presence of the stopper may impede a significant reduction of its surface area.…”

Section: Liposome Characterizationmentioning

confidence: 99%

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

et al. 2015

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The growing interest in the study of membraneactive ion (in particular, anion) transporters motivates the investigation of the mechanisms that underlie the transport process. The interest of the scientific community in this area is largely due to the great importance of transmembrane ion-transport phenomena in many diseases. In this paper we investigated the role of calix[6]arene-based pseudorotaxanes and rotaxanes on transmembrane transport of ions across the bilayer of liposomes composed of 1-palmitoyl-2-oleoylsn-glycero-3-phosphocholine (POPC; diameter 100 nm). We evaluated the effect of these interlocked systems on the properties of the bilayer and on membrane permeability towards chloride ions and 5(6)-carboxyfluorescein. These findings may pave the way for the construction of new generations of pharmacological systems regulating the transport of chloride ions.[a] Dr.

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Section: Liposome Characterizationmentioning

confidence: 99%

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

et al. 2015

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“…[88] Based on this fundamental understanding, researchers have incorporated Gd 3+ onto or into nanoscale carriers to enhance r1 of paramagnetic CAs. Compared to small Gd 3+ chelated complexes alone, nanocarriers (e.g., dendrimers, [89] polymers, [90] liposomes, [91] and inorganic nanoparticles (NPs) [92] ) allow dramatically increased Gd 3+ loading. In some cases, poor water accessibility to the intraparticular Gd 3+ buried inside the carriers can compromise the performance in T 1weighted MRI [93] and this challenge can be tackled by; for example, using porous nanocarriers [94] where a water molecule can travel from the bulk water into the interior space.…”

Section: Nanoparticle-based Mr Imagingmentioning

confidence: 99%

Supramolecular Nanoparticles for Molecular Diagnostics and Therapeutics

Chen

Garcia

Wang

et al. 2012

Supramolecular Chemistry

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Chapter 1. BACKGROUND …………………………………………………………………. Chapter 2. SUPRAMOLECULAR NANOPARTICLES (SNPs) ………………………….. My graduate study at UCLA was a precious, unique and memorable experience. All the challenges and experiences had happened made me grow stronger and wiser. Moreover, the acquired experiences and professional skills help me prepare myself to face any future challenges in my life and the next career. I could not have completed my Ph.D. journey at UCLA without the guidance, support, and encouragement of many people. Especially, I would like to thank my advisor, Prof. Hsian-Rong Tseng, for his great mentorship. I will never forget the lessons he taught me throughout the course of my research. His insight, guidance, inspiration, and support not only trained me to become an independent research scientist but also helped me to develop my own strength. Dr. Tseng is not just an advisor but a father figure to me. Just like a father, knowing that I could be better, he always has higher expectations on me. I am particularly grateful to the way he mentors me, which make me to accomplish lots of fruitful results and motivate me to achieve many ambitious goals. I have been fortunate to be surrounding by extremely hardworking, super friendly, and remarkably talented group members in Dr. Tseng's lab. In my first year of graduate training, I was assigned to work with two outstanding postdoc fellows (now are professors in China), Dr.

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“…These limitations result in the requirement for large doses and also limits their applicability in molecular imaging (Prince et al, 2009). To address these limitations, Gd(III) complexes have been conjugated to a wide variety of macromolecular scaffolds including dendrimers (Gang et al, 2010;Kobayashi, Brechbiel, 2005), linear polymers (Allen et al, 2006), proteins (Caravan et al, 2002), viral particles (Hooker et al, 2007), micelles (Accardo et al, 2004), liposomes (Schühle et al, 2010), and polymersomes (Cheng, Tsourkas, 2008;Grüll et al, 2010). This can result in improvements in r 1 values due to the slower tumbling rates of macromolecules and the resulting increases in the rotational correlation times of the Gd(III) (Caravan, 2006;Villaraza et al, 2010).…”

Section: Dendritic Functionalization Of Polymersomesmentioning

confidence: 99%

Dendritic surface functionalization of nanomaterials: controlling properties and functions for biomedical applications

Nazemi

Gillies

2013

Braz. J. Pharm. Sci.

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A wide variety of nanomaterials have demonstrated promise in medical applications such as drug delivery and imaging. In these applications, the surface chemistry of the materials is critical as it plays an important role in determining the toxicity and biodistribution behavior of the material. We review here the functionalization of nanomaterials with dendrons as an efficient method to alter the surface chemistry of the materials, introducing new properties and functions. Described here is the functionalization of superparamagnetic iron oxide nanoparticles (SPIO) with dendritic guanidines to enhance their transport into cells for magnetic resonance imaging applications. The introduction of dendrons bearing peripheral hydroxyls, amines, guanidines, carbohydrates and Gd(III) chelates to polymer vesicles (polymersomes) is also described. These dendritic moieties allow for modulation of toxicity, cell uptake, protein binding, and contrast agent efficiency, while at the same time allowing the stabilities of the polymersomes to be maintained. Thus, this approach holds promise for the development of a wide range of multifunctional materials for pharmaceutical applications.

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Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Abstract: w Electronic supplementary information (ESI) available: Synthesis of 1, preparation of liposomes, characterization of liposomes with DLS, SEC, cryo-TEM and DSC along with the model used for simulations and the results of simulations and fittings. See

Cited by 28 publications

References 12 publications

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

Incorporation of Calix[6]Arene Macrocycles and (Pseudo)Rotaxanes in Bilayer Membranes: Towards Controllable Artificial Liposomal Channels

Supramolecular Nanoparticles for Molecular Diagnostics and Therapeutics

Dendritic surface functionalization of nanomaterials: controlling properties and functions for biomedical applications

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