Liposomes: structure, composition, types, and clinical applications

Nsairat, Hamdi; Khater, Dima; Sayed, Usama; Odeh, Fadwa; Bawab, Abeer Al; Alshaer, Walhan

doi:10.1016/j.heliyon.2022.e09394

Cited by 417 publications

(218 citation statements)

References 211 publications

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“…For the liposomal component, cationic lipoplexes are sufficiently qualified for CRISPR delivery due to the enhanced encapsulation of negatively charged nucleic acid by electrostatic attraction. Additionally, cationic liposomes have a better chance of entering the trophoblast membrane through interacting with anionic surface lipids and proteoglycans ( Zhen and Li, 2020 ; Nsairat et al, 2022 ). The liposome lipoplexes’ cationic lipids form ionic bonds with the endosomal anionic membrane, which eventually results in lipoplex disassembly and the release of CRISPR content of the liposomes into the cytoplasm ( Kazemi Oskuee et al, 2016 ).…”

Section: Discussion and Future Directionmentioning

confidence: 99%

Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy

Yaghoobi

Nazerian

Meymand

et al. 2023

Front. Cell Dev. Biol.

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Assisted reproductive techniques as a new regenerative medicine approach have significantly contributed to solving infertility problems that affect approximately 15% of couples worldwide. However, the success rate of an in vitro fertilization (IVF) cycle remains only about 20%–30%, and 75% of these losses are due to implantation failure (the crucial rate-limiting step of gestation). Implantation failure and abnormal placenta formation are mainly caused by defective adhesion, invasion, and angiogenesis. Placental insufficiency endangers both the mother’s and the fetus’s health. Therefore, we suggested a novel treatment strategy to improve endometrial receptivity and implantation success rate. In this strategy, regulating mir-30d expression as an upstream transcriptomic modifier of the embryo implantation results in modified expression of the involved genes in embryonic adhesion, invasion, and angiogenesis and consequently impedes implantation failure. For this purpose, “scaffold/matrix attachment regions (S/MARs)” are employed as non-viral episomal vectors, transfecting into trophoblasts by exosome-liposome hybrid carriers. These vectors comprise CRISPR/dCas9 with a guide RNA to exclusively induce miR-30d gene expression in hypoxic stress conditions. In order to avoid concerns about the fetus’s genetic manipulation, our vector would be transfected specifically into the trophoblast layer of the blastocyst via binding to trophoblast Erb-B4 receptors without entering the inner cell mass. Additionally, S/MAR episomal vectors do not integrate with the original cell DNA. As an on/off regulatory switch, a hypoxia-sensitive promoter (HRE) is localized upstream of dCas9. The miR-30d expression increases before and during the implantation and placental insufficiency conditions and is extinguished after hypoxia elimination. This hypothesis emphasizes that improving the adhesion, invasion, and angiogenesis in the uterine microenvironment during pregnancy will result in increased implantation success and reduced placental insufficiency, as a new insight in translational medicine.

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Section: Discussion and Future Directionmentioning

confidence: 99%

Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy

Yaghoobi

Nazerian

Meymand

et al. 2023

Front. Cell Dev. Biol.

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“…The formulation that was employed was designed using just natural phosphatidylserine as an ingredient. It is hypothesised that natural phosphatidylserine would result in the formation of vesicles that are less durable and more permeable, which will encourage the uptake of liposomes through macrophages [ 134 ]. In addition, essential aspects such as the magnitude and kinetics of release of the GABA were not investigated.…”

Section: Nanoneurosciencementioning

confidence: 99%

Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience

et al. 2023

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Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have been progressively used by neuroscientists during the last several decades. The introduction of novel implantable bioelectronics interfaces that are better suited to their biological targets is one example of an innovation that has emerged as a result of advanced nanostructures and implantable bioelectronics interfaces, which has increased the potential of prostheses and neural interfaces. The unique physical–chemical properties of nanoparticles have also facilitated the development of novel imaging instruments for advanced laboratory systems, as well as intelligently manufactured scaffolds and microelectrodes and other technologies designed to increase our understanding of neural tissue processes. The incorporation of nanotechnology into physiology and cell biology enables the tailoring of molecular interactions. This involves unique interactions with neurons and glial cells in neuroscience. Technology solutions intended to effectively interact with neuronal cells, improved molecular-based diagnostic techniques, biomaterials and hybridized compounds utilized for neural regeneration, neuroprotection, and targeted delivery of medicines as well as small chemicals across the blood–brain barrier are all purposes of the present article.

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“…Currently, there are many liposomes' products available on the market that are approved to treat different diseases, and there are still researches ongoing to making stable liposomes because physical and chemical stabilities of liposomes formulation is the major obstacle. So, it's necessary to develop stable and efficient liposomes 102 .…”

Section: Different Nanoparticles Used In Nanotheranosticsmentioning

confidence: 99%

Interventional nanotheranostics in hepatocellular carcinoma

Chavda¹,

Balar²,

Patel³

2023

Nanotheranostics

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Interventional nanotheranostics is a system of drug delivery that does a dual function; along with the therapeutic action, it also does have diagnostic features. This method helps in early detection, targeted delivery, and the least chances of damage to surrounding tissue. It ensures the highest efficiency for the management of the disease. Imaging is the near future for the quickest and most accurate detection of disease. After combing both effective measures, it ensures the most meticulous drug delivery system. Nanoparticles such as Gold NPs, Carbon NPs, Silicon NPS, etc. The article emphasizes on effect of this delivery system in the treatment of Hepatocellular Carcinoma. It is one of the widely spreading diseases and theranostics is trying to make the scenario better. The review suggests the pitfall of the current system and how theranostics can help. It describes the mechanism used to generate its effect and believes that interventional nanotheranostics do have a future with rainbow color. The article also describes the current hindrance to the flourishing of this miraculous technology.

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Liposomes: structure, composition, types, and clinical applications

Cited by 417 publications

References 211 publications

Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy

Hypoxia-sensitive miRNA regulation via CRISPR/dCas9 loaded in hybrid exosomes: A novel strategy to improve embryo implantation and prevent placental insufficiency during pregnancy

Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience

Interventional nanotheranostics in hepatocellular carcinoma

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