Liposomes in dermatology today

Leeuw, Jaap de; Vijlder, H. C. de; Bjerring, Peter; Neumann, H. A. Martino

doi:10.1111/j.1468-3083.2009.03100.x

Cited by 128 publications

(70 citation statements)

References 111 publications

(278 reference statements)

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“…Liposomes 1-4 at a particle size of less than 150 nm, referring nanoparticles, is classified as Large, Unilamellar Vesicle (LUV; 50-150 nm). 36) A greater size liposome with cholesterol (liposome 6-9) corresponded to a reduced amount of lecithin. 37) Lecithin in the vesicle wall of greater than 95% controlled the size to less than 99 nm.…”

Section: Preparation and Stability Of The Salak Plum Peel Etoac Fractmentioning

confidence: 99%

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Kanlayavattanakul¹,

Lourith²,

Ospondpant³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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The antioxidant activities of Salak plum (Salacca edulis) peel extracts were assessed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 0 -azino-bis(3-ethylbenzothaiazoline)-6-sulfonic acid (ABTS), and ferric reducing ability of plasma (FRAP) assays. The ethyl acetate (EtOAc) fraction was the most potent (DPPH IC50 ¼ 2:932 AE 0:030 g/mL, ABTS IC50 ¼ 7:933 AE 0:049 g/mL, FRAP EC ¼ 7;844:44 AE 40:734). Chlorogenic acid was detected as the marker (1:400 AE 0:102 g/kg). The EtOAc fraction was non-cytotoxic in vero and normal human fibroblast (NHF) cells. It exhibited cellular oxidative prevention and damage treatment at 5-40 g/mL in NHF cells. Salak plum peel loaded liposome consisting of lecithin and hydrophobically modified hydroxyethylcellulose (HMHEC) was developed and found stable with adequate entrapment efficacy. Thus Salak plum peel was highlighted as a potential ecological antioxidant for health promotion aspects, and for cosmetics.

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Section: Preparation and Stability Of The Salak Plum Peel Etoac Fractmentioning

confidence: 99%

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Kanlayavattanakul¹,

Lourith²,

Ospondpant³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…Liposomal delivery systems can enhance the permeability of hydrophilic drugs and localize them to target tissues. 13 Moreover, phospholipids are nontoxic and biodegradable, and prolong the half-life of drugs to attain a sustained-release effect. Previous studies demonstrated that phospholipids exhibit their enhancing effect on the application of topical delivery.…”

Section: Introductionmentioning

confidence: 99%

Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier

Fang¹

2011

IJN

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Introduction Transcription factor p53 has a powerful tumor suppressing function that is associated with many cancers. Since the molecular weight of p53 is 53 kDa, it is difficult to transport across cell membranes. Thymidine dinucleotide (pTT) is an oligonucleotide that can activate the p53 transcription factor and trigger the signal transduction cascade. However, the negative charge and high water solubility of pTT limit its transport through cellular membranes, thereby preventing it from reaching its target in the nucleus. A suitable delivery carrier for pTT is currently not available. Objective The purpose of this study was to employ a nanoscale liposomal carrier to resolve the delivery problem, and increase the bioavailability and efficiency of pTT. Methodology The approach was to employ liposomes to deliver pTT and then evaluate the particle size and zeta potential by laser light scattering (LLS), and permeation properties of pTT in vitro in a Franz diffusion assembly, and in vivo in a murine model using confocal laser scanning microscopy (CLSM). Results We found that dioleoylphosphatidylethanolamine (DOPE) combined with cholesterol 3 sulfate (C3S) were the best ingredients to achieve an average desired vehicle size of 133.6 ± 2.8 nm, a polydispersity index (PDI, representing the distribution of particle sizes) of 0.437, and a zeta potential of −93.3 ± 1.88. An in vitro penetration study showed that the liposomal carrier was superior to the free form of pTT at 2–24 hours. CLSM study observed that the penetration depth of pTT reached the upper epidermis and potential of penetration maintained up to 24 hours. Conclusion These preliminary data demonstrate that nanosized DOPE/C3S liposomes can be exploited as a potential carrier of drugs for topical use in treating skin diseases.

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“…Liposomes have numerous potential pharmaceutical applications and can be safely administered by different routes of administration (Pierre & Dos Santos Miranda Costa, 2011). They can be also utilized in dermatology as a local drug depot in combination with penetration enhancers (de Leeuw et al, 2009;Pierre & Dos Santos Miranda Costa, 2011;Puglia & Bonina, 2012;Rahimpour & Hamishehkar, 2012). Furthermore, as antimicrobial drug delivery carriers, liposomes are able to enhance antibiotic concentrations at the site of infection (passive or active targeting), increase bactericidal efficacy (via fusion with the bacterial membrane), improve drug uptake and decrease the toxicity of potentially toxic antimicrobial agent (Fresta et al, 1995;Sachetelli et al, 2000;Mugabe et al, 2006b;Halwani et al, 2008, Drulis-Kawa et al, 2009.…”

Section: The Advantages Of Liposomes As Drug Carriersmentioning

confidence: 99%

Nanoliposome-based antibacterial drug delivery

Hallaj‐Nezhadi

Hassan

2013

Drug Delivery

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Although most bacterial infectious diseases can be treated successfully with the remarkable array of antibiotics, the microbial pathogens continue to be one of the most critical health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antibacterial delivery systems since inefficient delivery can lead to poor therapeutic outcome of the administered drug. Recently, nanoliposomal systems have been widely used as promising strategies to overcome these challenges due to their unique set of properties. This article tries to briefly summarize the current studies that have taken advantage of liposomal nanoparticles as carriers to deliver antibacterial agents. The reviewed investigations demonstrate the immense potential of liposomal nanoparticles as carriers for antibiotic delivery and highlight the latent promise in this class of vehicles for treatment of bacterial infections. The future of these promising approaches lies in the development of more efficient techniques for preparing liposomal nanoparticles with great potential in effective and selective targeting of antibiotics to bacterial cells for eradication as well as the highest safety for human host.

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Liposomes in dermatology today

Cited by 128 publications

References 111 publications

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Salak Plum Peel Extract as a Safe and Efficient Antioxidant Appraisal for Cosmetics

Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier

Nanoliposome-based antibacterial drug delivery

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