Liposomes for targeting hepatocellular carcinoma: Use of conjugated arabinogalactan as targeting ligand

Shah, Sanket M.; Goel, Peeyush N.; Jain, Arvind Kumar; Pathak, Pankaj O.; Padhye, S G; Govindarajan, Srinath; Ghosh, Sandipto; Chaudhari, Pradip; Gude, Rajiv P.; Gopal, Vijaya; Nagarsenker, Mangal S.

doi:10.1016/j.ijpharm.2014.10.014

Cited by 41 publications

(22 citation statements)

References 44 publications

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“…HepG2 xenograft nude mice models were built as described in our previous paper. 15 When the tumor volume reached about 300 mm 3 , the mice were intragastrically administered with different formulations, including free Cy5, Cy5-labeled C-MEs (Cy5/C-MEs) and Cy5-labeled Gal(oct)-C-MEs (Cy5/Gal(oct)-C-MEs) at a Cy5 dose of 250 μg/ kg. The NIR images were observed at determined intervals post-intragastric administration by in vivo imaging system equipped with an excitation band pass filter at 630 nm and an emission filter at 700 nm.…”

Section: In Vivo Imagingmentioning

confidence: 99%

“…The animal experiments were carried out in accordance with the protocol approved by the animal ethics committee of Nanjing University of Chinese Medicine (Nanjing, People's Republic of China). When the tumor volume reached about 80 mm 3 , the mice were randomly separated into five groups and treated with Gal(oct)-C-MEs, C-MEs and coix seed oil-MEs intragastrically each day for 14 days at a coix seed oil dose of 2.5 g/kg/day. Saline and Kanglaite injection (commercial formulation of coix seed oil, Kanglaite Pharmacy Inc., Zhejiang, China) were used as a negative and positive control, respectively.…”

Section: Antitumor Efficacy In Vivomentioning

confidence: 99%

“…2 Although chemotherapy is a most commonly used and effective approach for treatment of HCC, the severe systemic side effects resulting from nonselective biodistribution still enormously restrict the clinical applications. 3,4 Recently, nano-sized drug delivery system (DDS) showed a promising potentiality in tumor-specific accumulation by enhanced permeability and retention (EPR) effect. …”

Section: Introductionmentioning

confidence: 99%

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Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Qu¹,

Liu²,

Huang³

et al. 2017

IJN

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A nanosized drug delivery platform with a combination of rational components and tumor targeting is significant for enhancement of anticancer therapy and reduction of side effects. In this study, we developed a octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components (Gal(oct)-C-MEs), which improved the tumor accumulation through asialoglycoprotein receptor-mediated endocytosis and promoted the antitumor efficacy through multicomponent-mediated synergistic effect. Octanoyl galactose ester (Gal(oct)) with a yield of 82.3% was synthesized through a green enzymatic reaction and multidimensional characterization. Gal(oct)-C-MEs with a spherical shape had a small and uniform particle size (58.49±1.03 nm), narrow polydispersity index (0.09±0.01) and neutral surface charge (−5.82±0.57 mV). In the cellular uptake studies, the internalized Gal(oct)-C-ME was 2.28-fold higher relative to that of coix seed component-based microemulsions (C-MEs). The half-maximal inhibitory concentration of Gal(oct)-C-MEs against HepG2 cells was 46.5±2.4 μg/mL, which was notably higher than that of C-MEs. Importantly, the intratumor fluorescence of HepG2 xenograft-bearing nude mice treated with Cy5/Gal(oct)-C-MEs was 1.9-fold higher relative to treatment with Cy5/C-MEs. In the study of antitumor efficacy in vivo, HepG2 xenograft-bearing nude mice intragastrically administered Gal(oct)-C-MEs for 14 days exhibited the strongest inhibition of tumor growth and the lowest toxicity against liver and kidney among all the treatments. In summary, Gal(oct)-C-ME, as a highly effective and safe anticancer drug delivery system, showed promising potential for hepatoma therapy.

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Section: In Vivo Imagingmentioning

confidence: 99%

Section: Antitumor Efficacy In Vivomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Qu¹,

Liu²,

Huang³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…The cell growth in absence of any drug was considered 100% and in turn growth inhibition was calculated. GI50, TGI and LC50 values were determined by regression analysis [1,50,51]. The MTT assay was used for checking the anti-proliferative effects of the nanoformulated NSAIDs on A2780.…”

Section: Cell Culture and Srb Assaymentioning

confidence: 99%

“…Apart from improvements in solubility, derivatization of NAP also is known to enhance the anticancer activity. For example, IC 50 value of Naproxen sodium salt on MCF7 and MDA-MB-231 cell lines are >5 mM and ~10 mM respectively [68]. There is no consensus in the literature regarding the molecular mechanism of the anticancer activity of NSAIDs.…”

Section: Anticancer Activitymentioning

confidence: 99%

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Kumar

Siril

Javid

2016

Materials Science and Engineering: C

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The non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmaceuticals worldwide. Interestingly, many of them have significant anticancer properties too. However, the poor water solubility of certain NSAIDs limits their application for cancer treatment. Nanosizing of such drugs can help to improve the solubility and this may result in enhanced anticancer activities too. Moreover, over dosages and the accompanying side effects of NSAIDs can be minimized by improving their solubility and bioavailability. Successful nanoformulation of three NSAIDs: ibuprofen (IBP), ketoprufen (KP) and naproxen (NAP) using a novel evaporation assisted solvent-antisolvent interaction (EASAI) method is reported here. Three water soluble and biocompatible polymers: polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) were used to stabilize the drug nanoparticles. Particles having spherical morphology with average size below 30 nm were thoroughly characterized using dynamic light scattering and field emission scanning electron microscopy (FESEM) imaging. The nanoformulation resulted in ten to fifteen fold improvements in the solubility and significant enhancement in the in-vitro drug release profiles of the NSAIDs. Anticancer screening of the nanoformulated NSAIDs against five different cancer cell lines such as MCF-7 (Human breast cancer cell line), (Human pancreatic cancer cell line) MIA-PA-CA-2, (Human colon cancer cell line) HT-29, (Human leukemia cell line) Jurkat and (human ovarian carcinoma cell line) A2780 was performed. All the nanoformulated samples showed improved anticancer activity against the Leukemia cancer cell line, out of which NAP-PVP showed the highest anti-cancer activity. The anti-Leukemia activity of NAP-PVP was more than twice that of doxorubicin which is a standard anticancer drug.

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Magnetically‐activated lipid nanocarriers in biomedical applications: A review of current status and perspective

Sun

Tan

Boyd

2022

WIREs Nanomed Nanobiotechnol

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Magnetically-activated lipid nanocarriers have become a research hotspot in the field of biomedicine. Liposomes and other lipid-based carriers possess good biocompatibility as well as the ability to carrying therapeutic cargo with a range of physicochemical properties. Previous studies have demonstrated that magnetic materials have potential wide applications in clinical diagnosis and therapy, such as in MRI as contrast agents and in hyperthermic obliteration of cancer tissues. More recently magneto-thermal activation of lipid carriers to

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Liposomes for targeting hepatocellular carcinoma: Use of conjugated arabinogalactan as targeting ligand

Cited by 41 publications

References 44 publications

Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Octanoyl galactose ester-modified microemulsion system self-assembled by coix seed components to enhance tumor targeting and hepatoma therapy

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs

Magnetically‐activated lipid nanocarriers in biomedical applications: A review of current status and perspective

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