Liposomes for intravitreal drug delivery: A state of the art

Bochot, Amélie; Fattal, Elias

doi:10.1016/j.jconrel.2012.01.019

Cited by 191 publications

(126 citation statements)

References 89 publications

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“…29,30 Among potential nanocarriers, liposomes, an appealing candidate with decreased side effects, have attracted considerable attention. 31,32 The formulation Doxil®, which is doxorubicin (DOX) encapsulated in PEGylated liposomes, has been approved for clinical use against solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

et al. 2016

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He (2016) Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin, Autophagy, 12:6, 949-962, DOI: 10.1080/15548627.2016 HCQ/Lip-TR was efficiently internalized as a result of its ability to bind ITGAV-ITGB3/integrin a v b 3 receptors highly expressed on the tumor cell surface and to undergo charge reversal from anionic at pH 7.4 to cationic at pH 6.5. Studies in vitro at pH 6.5 showed that the intracellular HCQ concentration was 35.68-fold higher, and lysosomal HCQ concentration 32.22-fold higher, after treating cultures with HCQ/Lip-TR than after treating them with free HCQ. The corresponding enhancements observed in mice bearing B16F10 tumors were 15.16-fold within tumor cells and 14.10-fold within lysosomes. HCQ/Lip-TR was associated with milder anemia and milder myosuppressive reductions in white blood cell and platelet counts than free HCQ, as well as less accumulation in the small intestine, which may reduce risk of intestinal side effects. In addition, co-delivering HCQ/Lip-TR with either free doxorubicin (DOX) or liposomal DOX improved the ability of DOX to inhibit tumor growth. Biochemical, electron microscopy and immunofluorescence experiments confirmed that HCQ/Lip-TR blocked autophagic flux in tumor cells. Our results suggest that loading HCQ into Lip-TR liposomes may increase the effective concentration of the inhibitor in tumor cells, allowing less toxic doses to be used.

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Section: Introductionmentioning

confidence: 99%

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

et al. 2016

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“…Nonviral vectors on the other hand generally exhibit lower efficiency but higher safety and tractability. [22,23] A number of recent review articles has discussed the use of various non-viral gene delivery systems including liposomes, [24,25] nanoparticles [26][27][28][29][30] and dendrimers. [6,[10][11][12][13]23,[31][32][33][34][35][36] Dendrimers have gained great interest as gene delivery vehicles because of their monodisperisity, high density of functional groups, well-defined shape and multivalency.…”

Section: Dendrimers For Non-viral Gene Deliverymentioning

confidence: 99%

“…A number of recent articles has reviewed non-viral vectors for ocular delivery of nucleic acids. [24,25,[78][79][80][81][82] Table 2 gives an overview of some non-viral gene delivery systems recently explored for ocular therapy with polymeric nanoparticles and liposomes being the most widely investigated systems.…”

Section: Non-viral Ocular Gene Deliverymentioning

confidence: 99%

Dendrimers for gene delivery – a potential approach for ocular therapy?

Chaplot

Rupenthal

2013

Journal of Pharmacy and Pharmacology

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“…PLGA nanoparticles and liposomes have been compared in an in vitro environment for their ability to deliver anti-cancer agents across the sclera over time . However, the nature of these vesicles to float in the vitreous means that they will likely blur or impair vision 9 .…”

Section: Introductionmentioning

confidence: 99%

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Fiorani

Maccarone

Fernando

et al. 2014

JoVE

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Diseases of the retina are difficult to treat as the retina lies deep within the eye. Invasive methods of drug delivery are often needed to treat these diseases. Chronic retinal diseases such as retinal oedema or neovascularization usually require multiple intraocular injections to effectively treat the condition. However, the risks associated with these injections increase with repeated delivery of the drug. Therefore, alternative delivery methods need to be established in order to minimize the risks of reinjection. Several other investigations have developed methods to deliver drugs over extended time, through materials capable of releasing chemicals slowly into the eye. In this investigation, we outline the use of Elvax 40W, a copolymer resin, to act as a vehicle for drug delivery to the adult rat retina. The resin is made and loaded with the drug. The drug-resin complex is then implanted into the vitreous cavity, where it will slowly release the drug over time. This method was tested using 2-amino-4-phosphonobutyrate (APB), a glutamate analogue that blocks the light response of the retina. It was demonstrated that the APB was slowly released from the resin, and was able to block the retinal response by 7 days after implantation. This indicates that slow-release drug delivery using this copolymer resin is effective for treating the retina, and could be used therapeutically with further testing. Video LinkThe video component of this article can be found at

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Liposomes for intravitreal drug delivery: A state of the art

Cited by 191 publications

References 89 publications

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

Dendrimers for gene delivery – a potential approach for ocular therapy?

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

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